{
  "abstract": "Jasmonic acid (JA) is the precursor of the bioactive molecule jasmonoyl-isoleucine (JA-Ile), a plant hormone that regulates fitness and development. Although JA biosynthesis, signaling, and responses have been intensively studied, the catabolism of JA remains incompletely understood. Here, we use the recently developed technique of limited proteolysis-coupled mass spectrometry (LiP-MS) to investigate metabolite-protein interactions in plants, aiming to discover enzymes involved in JA metabolism. We identify several previously reported JA-binding proteins, thus validating the robustness of the method, along with recognized enzymes of the JA pathway and a series of other potential JA-binding proteins. Functional characterization of a set of identified JA-interacting uridine diphosphate (UDP)-glycosyltransferase (UGT) enzymes through omics, biochemical, enzymatic, and structural analyses reveals that two tomato UGTs glucosylate JA into JA-glucosyl esters, potentially playing a role in the regulation of bioactive JA homeostasis. With this, our findings uncover a missing step in the JA metabolic pathway.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Plant Biotechnology and Bioinformatics, Ghent University, 9052 Ghent, Belgium",
    "VIB Center for Plant Systems Biology, 9052 Ghent, Belgium",
    "Department of Plant Biochemistry, Albrecht-von-Haller-Institute for Plant Sciences, University of Goettingen, 37077 Goettingen, Germany",
    "Department of Organic and Macromolecular Chemistry, Ghent University, 9000 Ghent, Belgium",
    "Laboratory of Integrative Metabolomics (LIMET), Department of Translational Physiology, Infectiology and Public Health, Ghent University, 9820 Merelbeke, Belgium",
    "iRIP Unit, Laboratory of Microbiology, Department of Biochemistry and Microbiology, Ghent University, 9000 Ghent, Belgium",
    "Department of Plant Biochemistry, Goettingen Center for Molecular Biosciences (GZMB), University of Goettingen, 37077 Goettingen, Germany",
    "Department of Botany and Zoology, Stellenbosch University, Private Bag X1, Matieland 7600, South Africa"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 16,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Jhon Venegas-Molina"
    },
    {
      "affs": [
        2
      ],
      "name": "Lennart Mohnike"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Sara Selma García"
    },
    {
      "affs": [
        3
      ],
      "name": "Hilde Janssens"
    },
    {
      "affs": [
        4
      ],
      "name": "José Diana Di Mavungu"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Kaylan Reddy"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Robin Colembie"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Issl Kimpe"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Ana Cristina Jaramillo-Madrid"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Elia Lacchini"
    },
    {
      "affs": [
        4
      ],
      "name": "Lynn Vanhaecke"
    },
    {
      "affs": [
        3
      ],
      "name": "Johan M. Winne"
    },
    {
      "affs": [
        5
      ],
      "name": "Petra Van Damme"
    },
    {
      "affs": [
        2,
        6
      ],
      "name": "Ivo Feussner"
    },
    {
      "affs": [
        0,
        1,
        7
      ],
      "name": "Alain Goossens"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Krešimir Šola"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/2f5qv8r32cbxf.bib",
  "cited_by": 0,
  "doi": "10.1016/j.celrep.2026.118034",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13725468/",
  "id": "2f5qv8r32cbxf",
  "issns": [
    "2211-1247"
  ],
  "landing_url": "https://doi.org/10.1016/j.celrep.2026.118034",
  "language": "en",
  "licence": "CC-BY-NC-4.0",
  "licence_label": "CC BY-NC 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Article"
    ],
    [
      "openalex",
      "1312|Plant biochemistry and biosynthesis"
    ]
  ],
  "openalex": "W7214388138",
  "pdf_url": null,
  "pmcid": "PMC13725468",
  "pmid": "42789390",
  "published": "2026-09-25",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/2f5qv8r32cbxf.ris",
  "sources": [
    {
      "first_seen": "2026-11-04T12:23:51Z",
      "native_id": "PMC13725468",
      "source": "pmc",
      "url": "https://doi.org/10.1016/j.celrep.2026.118034"
    }
  ],
  "subjects": [
    {
      "field": "biochemistry",
      "origin": "openalex:1312|Plant biochemistry and biosynthesis",
      "subfield": "molecular-biology"
    }
  ],
  "title": "LiP-MS reveals a feedback loop of tomato UDP-glucosyltransferases managing bioactive jasmonate homeostasis",
  "title_text": "LiP-MS reveals a feedback loop of tomato UDP-glucosyltransferases managing bioactive jasmonate homeostasis",
  "type": "peer-reviewed",
  "updated_at": "2026-11-06T12:21:43Z",
  "url": "https://research.draconitic.com/paper/2f5qv8r32cbxf",
  "venue": "Cell Reports",
  "versions": []
}