{
  "abstract": "Objective: Sleep disturbances and depressive symptoms are prevalent non-motor burdens in Parkinson's disease (PD) and are closely associated with poorer health-related quality of life (QoL). Non-motor symptoms of PD exhibit substantial heterogeneity. It remains unclear whether distinct sleep disturbances show differential correlations with physical and mental QoL, and whether specific depressive subdimensions are implicated in these relationships. This exploratory study analyzed direct and indirect associations among sleep components, depressive subdimensions, and physical-mental QoL in hospitalized patients with PD.\n\nMethods: This retrospective study analyzed data from 55 hospitalized patients with idiopathic PD who completed the Pittsburgh Sleep Quality Index (PSQI), the 24-item Hamilton Depression Rating Scale (HAMD), the Montreal Cognitive Assessment (MoCA), and the 36-Item Short Form Health Survey (SF-36). Spearman correlation and multivariable regression analyses were performed to assess bivariate associations and independent correlates of QoL. Exploratory PROCESS analyses were further implemented as hypothesis-generating secondary analyses to examine symptom-level indirect associations; all findings were interpreted as cross-sectional and non-causal.\n\nResults: Spearman correlation analyses showed that the PSQI total score was significantly correlated with both PCS and MCS (both p < 0.01). Multivariable regression demonstrated that the HAMD total score was the only significant independent correlate of PCS (p = 0.025) and MCS (p = 0.004), whereas the PSQI total score reached no statistical significance in either model (p = 0.424 and p = 0.617, respectively). Exploratory PROCESS analyses identified two distinct symptom-level indirect association patterns: nocturnal sleep disturbances correlated with reduced physical QoL through HAMD Retardation, and poor subjective sleep quality correlated with lower mental QoL through HAMD Anxiety/Somatization.\n\nConclusion: Within this hospitalized PD cohort, depressive symptoms represented the dominant correlate of QoL. Specific sleep components exhibited indirect association patterns with QoL through distinct depressive subdimensions. These preliminary findings underline the heterogeneity of PD non-motor symptoms and provide a hypothesis-generating framework for future longitudinal validation and targeted intervention studies.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Neurological Rehabilitation & Neurology, Sichuan Bayi Rehabilitation Center (Sichuan Provincial Rehabilitation Hospital), Chengdu, Sichuan 611135, China",
    "Department of Neurosurgery, Chengdu Fifth People's Hospital (The Second Clinical Medical College, Affiliated Fifth People's Hospital of Chengdu University of Traditional Chinese Medicine), Chengdu, Sichuan 611137, China"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 2,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Liyin Zhang"
    },
    {
      "affs": [
        1
      ],
      "name": "Yongxiao Shuai"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/2f5rybzeg550v.bib",
  "cited_by": 0,
  "doi": "10.1016/j.prdoa.2026.100506",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13735288/",
  "id": "2f5rybzeg550v",
  "issns": [
    "2590-1125"
  ],
  "landing_url": "https://doi.org/10.1016/j.prdoa.2026.100506",
  "language": "en",
  "licence": "CC-BY-NC-ND-4.0",
  "licence_label": "CC BY-NC-ND 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Original Article"
    ],
    [
      "openalex",
      "2728|Parkinson's Disease Mechanisms and Treatments"
    ]
  ],
  "openalex": "W7214750381",
  "pdf_url": "https://www.sciencedirect.com/science/article/pii/S2590112526000861/pdf",
  "pmcid": "PMC13735288",
  "pmid": "42991120",
  "published": "2026-09-29",
  "publisher": "Elsevier",
  "ris": "https://research.draconitic.com/paper/2f5rybzeg550v.ris",
  "sources": [
    {
      "first_seen": "2026-11-09T12:20:59Z",
      "native_id": "PMC13735288",
      "source": "pmc",
      "url": "https://doi.org/10.1016/j.prdoa.2026.100506"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2728|Parkinson's Disease Mechanisms and Treatments",
      "subfield": "neurology"
    }
  ],
  "title": "Sleep components, depressive subdomains and quality of life in Parkinson's disease: A cross-sectional exploratory analysis",
  "title_text": "Sleep components, depressive subdomains and quality of life in Parkinson's disease: A cross-sectional exploratory analysis",
  "type": "peer-reviewed",
  "updated_at": "2026-11-09T12:20:59Z",
  "url": "https://research.draconitic.com/paper/2f5rybzeg550v",
  "venue": "Clinical Parkinsonism & Related Disorders",
  "versions": []
}