{
  "abstract": "Introduction: The Cholesterol-High-Density Lipoprotein-Glucose (CHG) index is a novel composite metabolic biomarker. We aimed to evaluate the relationship between the CHG index and albuminuria prevalence in patients with type 2 diabetes mellitus (T2DM).\n\nMethods: A total of 1842 T2DM patients at Jinjiang Municipal Hospital were enrolled in this cross-sectional study. Albuminuria was defined as a urinary albumin-to-creatinine ratio (UACR) > 30 mg/g. Multivariable logistic regression, restricted cubic spline modeling, subgroup analyses, and receiver operating characteristic (ROC) curve analysis were performed to evaluate the independent association.\n\nResults: Patients with albuminuria (n=324) had higher CHG index values. After full adjustment, an elevated CHG index was significantly associated with higher odds of albuminuria ( OR=2.097, 95%CI:1.438-3.060, P<0.001 ). Restricted cubic spline analysis revealed a J-shaped nonlinear relationship, with an inflection point at 6.402. The association was more pronounced in patients with hypertension. The CHG index demonstrated an area under curve (AUC) of 63.28% for distinguishing albuminuria, outperforming other metabolic indices.\n\nConclusions: The CHG index was nonlinearly associated with albuminuria prevalence in patients with T2DM; however, its cross-sectional design precludes causal inference.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Endocrinology & Metabolism, Jinjiang Municipal Hospital, Shanghai Sixth People’s Hospital Fujian , , ,"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 5,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Yuren Zhang"
    },
    {
      "affs": [
        0
      ],
      "name": "Jinting Xu"
    },
    {
      "affs": [
        0
      ],
      "name": "Yiping Zhang"
    },
    {
      "affs": [
        0
      ],
      "name": "Yinan Chen"
    },
    {
      "affs": [
        0
      ],
      "name": "Qiaolan Liu"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/2f89e1anemrb9.bib",
  "cited_by": 0,
  "doi": "10.3389/fendo.2026.1937841",
  "fulltext_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13668542/?tool=EBI",
  "id": "2f89e1anemrb9",
  "issns": [
    "1664-2392"
  ],
  "landing_url": "https://europepmc.org/article/PMC/PMC13668542",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2727|Chronic Kidney Disease and Diabetes"
    ]
  ],
  "openalex": "W7215106528",
  "pdf_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13668542/pdf/?tool=EBI",
  "pmcid": "PMC13668542",
  "pmid": null,
  "published": "2026-10-01",
  "publisher": "Frontiers Media SA",
  "ris": "https://research.draconitic.com/paper/2f89e1anemrb9.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:18:18Z",
      "native_id": "PMC:PMC13668542",
      "source": "europepmc",
      "url": "https://europepmc.org/article/PMC/PMC13668542"
    },
    {
      "first_seen": "2026-10-30T12:20:20Z",
      "native_id": "10.3389/fendo.2026.1937841",
      "source": "crossref",
      "url": "https://www.frontiersin.org/articles/10.3389/fendo.2026.1937841/full"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "issn:1664-2392",
      "subfield": "endocrinology-metabolism"
    }
  ],
  "title": "Association between the cholesterol-high-density lipoprotein-glucose (CHG) index and albuminuria risk in diabetic patients",
  "title_text": "Association between the cholesterol-high-density lipoprotein-glucose (CHG) index and albuminuria risk in diabetic patients",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:20:20Z",
  "url": "https://research.draconitic.com/paper/2f89e1anemrb9",
  "venue": "Frontiers in endocrinology",
  "versions": []
}