{
  "abstract": "Background: This study aimed to evaluate the impact of a structured weight-loss intervention on liver steatosis and liver stiffness in adults with obesity.\n\nMethods: Post hoc analysis of prospectively collected data from a randomized crossover trial (NCT05420311) assessing changes in liver-related outcomes measured from baseline to three months during the overall sequential lifestyle intervention in adults with obesity. Participants sequentially followed a calorie-restricted standard diet, calorie-restricted ketogenic diet (KD), or modified alternate day fasting (mADF)—one month per diet—. Changes in controlled attenuation parameter (CAP), liver stiffness measurement (LSM) and estimated steatosis/LSM-based fibrosis risk categories assessed by vibration-controlled transient elastography were evaluated from baseline to three months during the overall sequential lifestyle intervention. Other assessments included changes in liver enzymes, anthropometric, and cardiometabolic parameters.\n\nResults: Seventy-six participants were included in this subanalysis. Mean weight loss was 7.6 ± 4.7 kg at the end of the study period. Significant reductions in CAP and LSM from baseline to 3 months were observed (from 286.6 ± 70.7 dB/m to 256.6 ± 57.1, p < 0.001, and from 8.8 ± 6.0 kPa to 6.9 ± 3.5 kPa, p = 0.012, respectively). In addition, a significant reduction in the percentage of patients with liver steatosis and LSM-based fibrosis risk ≥F2 was observed. Significant decreases in serum levels of liver enzymes (aspartate aminotransferase, alanine aminotransferase, and gamma-glutamyl transferase) were also detected.\n\nConclusions: A structured weight-loss lifestyle intervention may be associated with improvements in non-invasive liver-related outcomes in adults with obesity.\n\nTrial registration: ClinicalTrials.gov (NCT05420311).",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 9,
  "authors": [
    {
      "name": "Alba Rodriguez-Muñoz"
    },
    {
      "name": "José Ignacio Martínez-Montoro",
      "orcid": "0000-0001-9761-6888"
    },
    {
      "name": "Cristina María Díaz-Perdigones"
    },
    {
      "name": "Alba Subiri-Verdugo"
    },
    {
      "name": "Daniel Hinojosa-Nogueira"
    },
    {
      "name": "Virginia Mela"
    },
    {
      "name": "Alberto Vilches-Pérez"
    },
    {
      "name": "Isabel Moreno-Indias"
    },
    {
      "name": "Francisco J. Tinahones"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/2fac1zswcrenx.bib",
  "cited_by": 0,
  "doi": "10.1186/s12916-026-05345-2",
  "fulltext_url": null,
  "id": "2fac1zswcrenx",
  "issns": [
    "1741-7015"
  ],
  "landing_url": "https://link.springer.com/article/10.1186/s12916-026-05345-2",
  "language": null,
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2713|Liver Disease Diagnosis and Treatment"
    ]
  ],
  "openalex": "W7223665865",
  "pdf_url": null,
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-26",
  "publisher": "Springer Science and Business Media LLC",
  "ris": "https://research.draconitic.com/paper/2fac1zswcrenx.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:19:53Z",
      "native_id": "10.1186/s12916-026-05345-2",
      "source": "crossref",
      "url": "https://link.springer.com/article/10.1186/s12916-026-05345-2"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2713|Liver Disease Diagnosis and Treatment",
      "subfield": "epidemiology-public-health"
    }
  ],
  "title": "Impact of a lifestyle intervention for weight loss on liver-related outcomes in adults with obesity: a subanalysis of a clinical trial",
  "title_text": "Impact of a lifestyle intervention for weight loss on liver-related outcomes in adults with obesity: a subanalysis of a clinical trial",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:19:53Z",
  "url": "https://research.draconitic.com/paper/2fac1zswcrenx",
  "venue": "BMC Medicine",
  "versions": []
}