{
  "abstract": "Photoinactivation allows precise spatiotemporal control of biomolecules in biological systems. Among the photoinactivation strategies, photooxygenation is advantageous, as it can be readily induced with a photosensitizer upon photoirradiation in biological environment. However, its utility is limited by poor target selectivity arising from the excessive generation and high reactivity of reactive oxygen species. Here, target-selective photoinactivation of myostatin is achieved using a target-binding ligand functionalized with a molecular rotor-based photosensitizing unit whose photooxygenation activity is enhanced upon binding to the target protein. A novel molecular rotor-based photosensitizer was developed and conjugated to a myostatin-binding peptide. The resulting functionalized peptide selectively oxygenated and inactivated myostatin under near-infrared irradiation. Treatment with the peptide followed by irradiation decreased endogenous myostatin levels in skeletal muscle, leading to increased muscle weight and muscle fiber size. This target-selective photoinactivation strategy may expand the applicability of photoresponsive approaches for the treatment of various diseases, including muscular dystrophy.",
  "abstract_shown": true,
  "affiliations": [
    "Laboratory of Medicinal Chemistry, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, 1432-1 Horinouchi, Hachioji, Tokyo, Japan, 192-0392",
    "Laboratory of Drug Delivery and Molecular Biopharmaceutics, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, 1432-1 Horinouchi, Hachioji, Tokyo, Japan, 192-0392",
    "Laboratory of Synthetic Organic Chemistry, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, 1432-1 Horinouchi, Hachioji, Tokyo , Japan, 192-0392"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 11,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Kaoru Ikekawa"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Hideyuki Okamoto"
    },
    {
      "affs": [
        0
      ],
      "name": "Shuko Amber Murano"
    },
    {
      "affs": [
        0
      ],
      "name": "Jo Yamamoto"
    },
    {
      "affs": [
        0
      ],
      "name": "Kota Inada"
    },
    {
      "affs": [
        0
      ],
      "name": "Sho Konno"
    },
    {
      "affs": [
        0
      ],
      "name": "Akihiro Taguchi"
    },
    {
      "affs": [
        2
      ],
      "name": "Hikaru Yanai"
    },
    {
      "affs": [
        1
      ],
      "name": "Yoichi Negishi"
    },
    {
      "affs": [
        0
      ],
      "name": "Yoshio Hayashi"
    },
    {
      "affs": [
        0
      ],
      "name": "Atsuhiko Taniguchi",
      "orcid": "0000-0002-5857-3093"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/2fexe59ahq3hv.bib",
  "cited_by": 0,
  "doi": "10.26434/chemrxiv.15008871/v1",
  "fulltext_url": null,
  "id": "2fexe59ahq3hv",
  "issns": [],
  "landing_url": "https://chemrxiv.org/doi/full/10.26434/chemrxiv.15008871/v1",
  "language": null,
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2505|Photochromic and Fluorescence Chemistry"
    ]
  ],
  "openalex": "W7213240866",
  "pdf_url": "https://chemrxiv.org/doi/pdf/10.26434/chemrxiv.15008871/v1",
  "pmcid": null,
  "pmid": null,
  "published": "2026-09-15",
  "publisher": "American Chemical Society (ACS)",
  "ris": "https://research.draconitic.com/paper/2fexe59ahq3hv.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:19Z",
      "native_id": "10.26434/chemrxiv.15008871",
      "source": "chemrxiv",
      "url": "https://chemrxiv.org/doi/full/10.26434/chemrxiv.15008871/v1"
    }
  ],
  "subjects": [
    {
      "field": "chemistry",
      "origin": "openalex:2505|Photochromic and Fluorescence Chemistry",
      "subfield": "materials-polymers"
    }
  ],
  "title": "Molecular rotor-regulated target-selective photoinactivation of myostatin",
  "title_text": "Molecular rotor-regulated target-selective photoinactivation of myostatin",
  "type": "preprint",
  "updated_at": "2026-10-30T12:17:19Z",
  "url": "https://research.draconitic.com/paper/2fexe59ahq3hv",
  "venue": "ChemRxiv",
  "versions": []
}