{
  "abstract": "Context: High-quality evidence on Lianhua Qingwen (LHQW) for treating influenza in children remains limited.\n\nObjective: To evaluate the efficacy and safety of LHQW in children aged 3–14 years with influenza, compared with oseltamivir.\n\nMaterials and methods: In this multicenter, randomized, double-blind, positive parallel-controlled trial, participants were randomly assigned (1:1) to receive either LHQW + oseltamivir placebo or oseltamivir + LHQW placebo. The primary outcome was clinical recovery time. Secondary outcomes included time to defervescence, symptom scores on the Canadian Acute Respiratory Illness and Flu Scale, the incidence of complications and severe/critical influenza, and the improvement rates for individual influenza symptoms. Safety outcomes were assessed based on adverse events.\n\nResults: A total of 520 participants were randomized (260 per group). Baseline characteristics were comparable. Median clinical recovery time was 5 days in both groups, with similar clinical recovery rates (71.5% vs. 71.2%; HR: 1.04, 95% CI: 0.84–1.29; one-sided p < 0.025). Median time to defervescence was shorter with LHQW (24 h vs. 30 h, p < 0.05). LHQW showed higher improvement rates for cough (56.9% vs. 45.5%) and sore throat (90.9% vs. 74.2%) (both p < 0.05). No severe or critical influenza occurred in the LHQW group. Adverse events incidence was similar between groups (p > 0.05).\n\nDiscussion: LHQW may offer a safe and effective alternative to oseltamivir for pediatric influenza, with particular benefits for defervescence, cough, and sore throat.\n\nConclusions: LHQW was non-inferior to oseltamivir in clinical recovery time and resulted in faster defervescence and greater improvement in cough and sore throat, with comparable safety.\n\nClinical trial registration number: ChiCTR1900028390 (Chinese Clinical Trial Registry, Dec. 20, 2019)",
  "abstract_shown": true,
  "affiliations": [
    "Department of Respiratory, Beijing Children’s Hospital, China National Clinical Research Center for Respiratory Disease, National Center for Children’s Health, Capital Medical University, Beijing, China",
    "National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, China",
    "Luohe Hospital of Traditional Chinese Medicine, Luohe, China",
    "Second Affiliated Hospital of Guizhou University of Traditional Chinese Medicine, Guiyang, China",
    "Shandong University of Traditional Chinese Medicine Affiliated Hospital, Jinan, China",
    "Sanmenxia Central Hospital, Sanmenxia, China",
    "Hebei Provincial Traditional Chinese Medicine Hospital, Shijiazhuang, China",
    "The First Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou, China",
    "State Key Laboratory for Innovation and Transformation of Luobing Theory, Shijiazhuang, China",
    "Hebei Academy of Integrated Traditional Chinese and Western Medicine, Shijiazhuang, China",
    "Hebei Yiling Hospital, Shijiazhuang, China",
    "Respiratory Department, Shenzhen Children’s Hospital, Shenzhen, China"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 14,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Fengxia Xue"
    },
    {
      "affs": [
        0
      ],
      "name": "Jialin Li",
      "orcid": "0000-0003-3184-8023"
    },
    {
      "affs": [
        1
      ],
      "name": "Siyuan Hu"
    },
    {
      "affs": [
        1
      ],
      "name": "Chengliang Zhong"
    },
    {
      "affs": [
        2
      ],
      "name": "Ziwei Feng"
    },
    {
      "affs": [
        3
      ],
      "name": "Zhu Chen"
    },
    {
      "affs": [
        4
      ],
      "name": "Baoqing Zhang"
    },
    {
      "affs": [
        5
      ],
      "name": "Chunying Ma"
    },
    {
      "affs": [
        6
      ],
      "name": "Shaoyi Geng"
    },
    {
      "affs": [
        7
      ],
      "name": "Xianqing Ren"
    },
    {
      "affs": [
        8,
        9,
        10
      ],
      "name": "Zhenhua Jia"
    },
    {
      "affs": [
        0
      ],
      "name": "Baoping Xu"
    },
    {
      "affs": [
        0,
        11
      ],
      "name": "Kunling Shen"
    },
    {
      "affs": [
        1
      ],
      "name": "Rong Ma"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/2fffn83s1wxmf.bib",
  "cited_by": 0,
  "doi": "10.1080/13880209.2026.2753284",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13717765/",
  "id": "2fffn83s1wxmf",
  "issns": [
    "1388-0209",
    "1744-5116"
  ],
  "landing_url": "https://doi.org/10.1080/13880209.2026.2753284",
  "language": "en",
  "licence": "CC-BY-NC-4.0",
  "licence_label": "CC BY-NC 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Research Article"
    ],
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      "openalex",
      "2713|Influenza Virus Research Studies"
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  "openalex": "W7224119888",
  "pdf_url": "https://www.tandfonline.com/doi/pdf/10.1080/13880209.2026.2753284?needAccess=true",
  "pmcid": "PMC13717765",
  "pmid": "42947434",
  "published": "2026-10-27",
  "publisher": "Taylor & Francis",
  "ris": "https://research.draconitic.com/paper/2fffn83s1wxmf.ris",
  "sources": [
    {
      "first_seen": "2026-11-02T12:22:01Z",
      "native_id": "PMC13717765",
      "source": "pmc",
      "url": "https://doi.org/10.1080/13880209.2026.2753284"
    }
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  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2713|Influenza Virus Research Studies",
      "subfield": "epidemiology-public-health"
    }
  ],
  "title": "Efficacy and safety of Lianhua Qingwen versus oseltamivir in children with influenza: a multicenter, randomized, double-blind, positive parallel-controlled study",
  "title_text": "Efficacy and safety of Lianhua Qingwen versus oseltamivir in children with influenza: a multicenter, randomized, double-blind, positive parallel-controlled study",
  "type": "peer-reviewed",
  "updated_at": "2026-11-02T12:22:01Z",
  "url": "https://research.draconitic.com/paper/2fffn83s1wxmf",
  "venue": "Pharmaceutical Biology",
  "versions": []
}