{
  "abstract": "Background\n\nCarcinoid heart disease (CaHD) is a severe complication of metastatic neuroendocrine tumors characterized by serotonin-mediated fibrotic degeneration of right-sided cardiac valves.Case summary\n\nWe present 3 patients with metastatic neuroendocrine tumors complicated by severe carcinoid valvulopathy involving native and prosthetic tricuspid valves. Two patients underwent bioprosthetic tricuspid valve replacement for severe tricuspid regurgitation, including 1 patient who developed rapid recurrent prosthetic valve degeneration requiring transcatheter tricuspid valve-in-valve replacement. A third patient presented with advanced bivalvular carcinoid involvement requiring complex surgical reconstruction complicated by postoperative cardiogenic shock and death.Discussion\n\nThese cases illustrate the progressive nature of serotonin-mediated valvular degeneration, challenges in prosthetic valve selection, and the importance of multidisciplinary management and close echocardiographic surveillance in CaHD.Take-home messages\n\nPersistent serotonin exposure may result in rapid degeneration of native and bioprosthetic valves despite surgical intervention. Early recognition and multidisciplinary management are essential to optimize outcomes in CaHD.",
  "abstract_shown": true,
  "affiliations": [
    "Miami Cardiac & Vascular Institute, Baptist Health South Florida, Miami, Florida, USA.",
    "Miami Cardiac & Vascular Institute, Baptist Health South Florida, Miami, Florida, USA. Electronic address: Abraham.Abdemur@Baptisthealth.Net.",
    "Herbert Wertheim College of Medicine, Florida International University, Miami, Florida, USA."
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 10,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Lucia Trabucchi"
    },
    {
      "affs": [
        0
      ],
      "name": "Richiele Forgiarini"
    },
    {
      "affs": [
        0
      ],
      "name": "Maria I Ardid"
    },
    {
      "affs": [
        1
      ],
      "name": "Abraham Abdemur"
    },
    {
      "affs": [
        0
      ],
      "name": "Raul E Herrera"
    },
    {
      "affs": [
        2
      ],
      "name": "Rodolfo Arce"
    },
    {
      "affs": [
        0
      ],
      "name": "Tom C Nguyen"
    },
    {
      "affs": [
        0
      ],
      "name": "Ramon Quesada"
    },
    {
      "affs": [
        0
      ],
      "name": "Elliott J Elias"
    },
    {
      "affs": [
        0
      ],
      "name": "Nish Patel"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/2fmwvpghkwk8m.bib",
  "cited_by": 0,
  "doi": "10.1016/j.jaccas.2026.110337",
  "fulltext_url": "https://europepmc.org/articles/PMC13669901",
  "id": "2fmwvpghkwk8m",
  "issns": [
    "2666-0849"
  ],
  "landing_url": "https://europepmc.org/article/MED/42847575",
  "language": "eng",
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2705|Cardiac Valve Diseases and Treatments"
    ]
  ],
  "openalex": "W7220860684",
  "pdf_url": "https://europepmc.org/articles/PMC13669901?pdf=render",
  "pmcid": "PMC13669901",
  "pmid": "42847575",
  "published": "2026-10-01",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/2fmwvpghkwk8m.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:18:10Z",
      "native_id": "MED:42847575",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42847575"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2705|Cardiac Valve Diseases and Treatments",
      "subfield": "cardiovascular"
    }
  ],
  "title": "Rapid Native and Bioprosthetic Tricuspid Valve Degeneration in Carcinoid Heart Disease.",
  "title_text": "Rapid Native and Bioprosthetic Tricuspid Valve Degeneration in Carcinoid Heart Disease.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:18:10Z",
  "url": "https://research.draconitic.com/paper/2fmwvpghkwk8m",
  "venue": "JACC. Case reports",
  "versions": []
}