{
  "abstract": "Direct oral anticoagulants, including rivaroxaban, are widely prescribed for the prevention and treatment of thromboembolic disorders. Despite generally predictable pharmacokinetics (PK), real-world data reveal striking interindividual variability in exposure, raising concerns for both efficacy and bleeding risk. Known genetic and clinical determinants explain only part of this variability, underscoring the need to identify additional contributors. This study aimed to explore systemic protein signatures associated with rivaroxaban exposure intensity. Plasma samples were obtained from 64 participants in a phase I clinical study (NCT04180436) including healthy controls, obese patients, and post-bariatric surgery patients. Rivaroxaban PK was assessed after 20 mg once-daily dosing, and patients were stratified into high and low exposure groups. Untargeted plasma proteomic analysis was performed by liquid chromatography coupled with high-resolution mass spectrometry, followed by Abbreviations: A30, Protein A30; ABCB1, ATP-binding cassette sub-family B member 1 gene; ABI3, ABI Family Member 3; ADAMTS13, A disintegrin and metalloproteinase with thrombospondin motifs 13; AGT, Angiotensinogen; ALB, Albumin; anti-EDB-scFv, Single-chain variable fragment anti-EDB; APOB, Apolipoprotein B; APOE, Apolipoprotein E; AUC_D1, Area under the concentration-time curve at day 1 after the first dose; AUC_SS, Area under the concentration-time curve at steady state; BER, Balanced error rate; BST1, Bone marrow stromal cell antigen 1; C7, Complement component 7; CC1, Complement component 1; CD5L, CD5 Antigen-Like; CDHR2, Cadherin-related family member 2; CHL1, Close homolog of L1; Cmax_D1, Maximum plasma concentration at day 1 after the first dose; Cmax_SS, Maximum plasma concentration at steady state; COL6A3, Collagen type VI alpha 3 Chain; COLEC10, Collectin subfamily member 10; CRP, C-reactive protein; CRISP3, Cysteine-rich secretory protein 3; CSF1R, Colony-stimulating factor 1 receptor; CST3, Cystatin C; CTSD,",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 10,
  "authors": [
    {
      "name": "Catherine Feliu"
    },
    {
      "name": "Jean Escal"
    },
    {
      "name": "Cyril Leven"
    },
    {
      "name": "Sophie Hodin"
    },
    {
      "name": "Vanessa Rigaud"
    },
    {
      "name": "Philippe Gonzalo"
    },
    {
      "name": "Francis Coutureau"
    },
    {
      "name": "Karine Lacut"
    },
    {
      "name": "Jeremy Thereaux"
    },
    {
      "name": "Xavier Delavenne"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/2fvper1ej3fjc.bib",
  "cited_by": 2,
  "doi": "10.1016/j.bcp.2025.117663",
  "fulltext_url": null,
  "id": "2fvper1ej3fjc",
  "issns": [
    "0006-2952",
    "1873-2968"
  ],
  "landing_url": "https://univ-brest.hal.science/hal-05733571v1",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "hal",
      "0.sdv"
    ],
    [
      "openalex",
      "3004|Pharmacogenetics and Drug Metabolism"
    ]
  ],
  "openalex": "W7116632097",
  "pdf_url": "https://univ-brest.hal.science/hal-05733571/document",
  "pmcid": null,
  "pmid": "41435887",
  "published": "2026-09-01",
  "publisher": "Elsevier",
  "ris": "https://research.draconitic.com/paper/2fvper1ej3fjc.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:24Z",
      "native_id": "hal-05733571",
      "source": "hal",
      "url": "https://univ-brest.hal.science/hal-05733571v1"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:3004|Pharmacogenetics and Drug Metabolism",
      "subfield": "pharmacology-toxicology"
    }
  ],
  "title": "Inflammatory protein signatures associated with high rivaroxaban exposure",
  "title_text": "Inflammatory protein signatures associated with high rivaroxaban exposure",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:17:24Z",
  "url": "https://research.draconitic.com/paper/2fvper1ej3fjc",
  "venue": "Biochemical Pharmacology",
  "versions": []
}