{
  "abstract": "Comparative data on reduced‐dose (8 Gy) versus standard‐dose (12 Gy) total body irradiation (TBI) before allogeneic haematopoietic stem cell transplantation (allo‐HSCT) for adults with acute lymphoblastic leukaemia (ALL) remain limited. We retrospectively analysed 101 adults undergoing first allo‐HSCT between 1999 and 2024 after 8 Gy or 12 Gy fractionated TBI‐based conditioning. Relapse and non‐relapse mortality (NRM) were analysed using multivariable Fine–Gray models. Median follow‐up was 8.1 years. Although the 8 Gy cohort was older, had greater comorbidity burden and a higher‐risk disease profile, unadjusted NRM, relapse incidence and overall survival did not differ between groups. In multivariable analyses, 12 Gy TBI was associated with increased NRM (sub‐distribution hazard ratio 5.97, 95% confidence interval [CI] 1.77–20.15; p = 0.004) without evidence of reduced relapse incidence. The association between 12 Gy TBI and higher NRM was consistent across sensitivity analyses, including adjustment for transplant year and conditioning regimen, cause‐specific Cox regression and propensity score overlap weighting. The association of 12 Gy TBI with inferior overall survival in the multivariable model was not confirmed after overlap weighting. Consistent pre‐transplant measurable residual disease data were unavailable, limiting adjustment for this prognostic factor. These findings support prospective evaluation of reduced‐dose TBI in selected adults with ALL.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Radiation Oncology University Hospital Regensburg Regensburg Germany",
    "Department of Internal Medicine III University Hospital Regensburg Regensburg Germany",
    "Leibniz Institute for Immunotherapy Regensburg Germany"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 8,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Isabella Gruber",
      "orcid": "0000-0002-7435-9337"
    },
    {
      "affs": [
        1,
        2
      ],
      "name": "Matthias Edinger"
    },
    {
      "affs": [
        1
      ],
      "name": "Hendrik Poeck"
    },
    {
      "affs": [
        1
      ],
      "name": "Elisabeth Meedt"
    },
    {
      "affs": [
        1
      ],
      "name": "Ernst Holler"
    },
    {
      "affs": [
        1
      ],
      "name": "Wolfgang Herr"
    },
    {
      "affs": [
        0
      ],
      "name": "Oliver Koelbl"
    },
    {
      "affs": [
        1
      ],
      "name": "Daniel Wolff",
      "orcid": "0000-0001-7015-3190"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/2gk2hngrq6haf.bib",
  "cited_by": 1,
  "doi": "10.1111/bjh.70835",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13748353/",
  "id": "2gk2hngrq6haf",
  "issns": [
    "0007-1048",
    "1365-2141"
  ],
  "landing_url": "https://doi.org/10.1111/bjh.70835",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "ORIGINAL PAPER"
    ],
    [
      "heading",
      "Original Paper"
    ],
    [
      "heading",
      "Transplantation & Cellular Therapy"
    ],
    [
      "openalex",
      "2720|Hematopoietic Stem Cell Transplantation"
    ]
  ],
  "openalex": "W7213312570",
  "pdf_url": "https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/bjh.70835",
  "pmcid": "PMC13748353",
  "pmid": "42740588",
  "published": "2026-09-15",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/2gk2hngrq6haf.ris",
  "sources": [
    {
      "first_seen": "2026-11-13T12:26:12Z",
      "native_id": "PMC13748353",
      "source": "pmc",
      "url": "https://doi.org/10.1111/bjh.70835"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2720|Hematopoietic Stem Cell Transplantation",
      "subfield": "general"
    }
  ],
  "title": "Reduced‐dose versus standard‐dose total body irradiation before allogeneic haematopoietic stem cell transplantation in adults with acute lymphoblastic leukaemia",
  "title_text": "Reduced‐dose versus standard‐dose total body irradiation before allogeneic haematopoietic stem cell transplantation in adults with acute lymphoblastic leukaemia",
  "type": "peer-reviewed",
  "updated_at": "2026-11-13T12:26:12Z",
  "url": "https://research.draconitic.com/paper/2gk2hngrq6haf",
  "venue": "British Journal of Haematology",
  "versions": []
}