{
  "abstract": "Coordinated uterine peristalsis positions embryos for implantation, but the mechanotransduction pathways controlling uterine wave coordination are not well defined. We combined smooth-muscle-specific deletion of titin M-band exons 1 and 2 with vertical agarose gel electrophoresis, mass spectrometry, uterine ring myography, imaging, transcriptomics, spatial proteomics, and targeted immunoblotting. We show that the myometrium expresses smooth-muscle titin and low-abundance full-length titin including the M-band kinase region. Conditional M-band deletion increased oxytocin-evoked force and area-under-the-curve while reducing coordinated wall motion, yielding fewer as well as crowded/mislocalized implantation sites and heavier placentas. Proteomics and immunoblotting identified disruption of an NBR1/p62 autophagy hub with downstream remodeling of excitability, metabolism, and wall mechanics. Reduced telokin and MLCK levels are consistent with impaired relaxation and increased Ca²⁺-sensitization. Together, these findings establish the titin M-band as a mechanotransductive signaling hub regulating peri-implantation motility with potential clinical relevance for optimizing implantation after in vitro fertilization and preventing ectopic pregnancy.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": "Article",
  "arxiv": null,
  "author_total": 12,
  "authors": [
    {
      "name": "V Juhi Sur"
    },
    {
      "name": "Claudia Fink"
    },
    {
      "name": "Nora Bergmann"
    },
    {
      "name": "Rene Jüttner"
    },
    {
      "name": "Melissa Klingeberg"
    },
    {
      "name": "Fabian Coscia"
    },
    {
      "name": "Lorena Suarez-Artiles"
    },
    {
      "name": "Philipp Mertins"
    },
    {
      "name": "Johanna Elisabeth Fritsch"
    },
    {
      "name": "Melissa Birol"
    },
    {
      "name": "Maik Gollasch"
    },
    {
      "name": "Michael Gotthardt",
      "orcid": "0000-0003-1788-3172"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/2gn06q26vzxp3.bib",
  "cited_by": 0,
  "doi": "10.1016/j.isci.2026.117888",
  "fulltext_url": "https://europepmc.org/articles/PMC13694822",
  "id": "2gn06q26vzxp3",
  "issns": [
    "2589-0042"
  ],
  "landing_url": "https://www.cell.com/iscience/fulltext/S2589-0042(26)03271-2",
  "language": "eng",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "http://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Cell biology"
    ],
    [
      "heading",
      "Cellular physiology"
    ],
    [
      "heading",
      "Human Physiology"
    ],
    [
      "openalex",
      "1307|Cellular Mechanics and Interactions"
    ]
  ],
  "openalex": "W7221789804",
  "pdf_url": "https://europepmc.org/articles/PMC13694822?pdf=render",
  "pmcid": "PMC13694822",
  "pmid": "42927188",
  "published": "2026-10-14",
  "publisher": "Elsevier BV",
  "ris": "https://research.draconitic.com/paper/2gn06q26vzxp3.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:16Z",
      "native_id": "10.1016/j.isci.2026.117888",
      "source": "feed-cell",
      "url": "https://www.cell.com/iscience/fulltext/S2589-0042(26)03271-2"
    },
    {
      "first_seen": "2026-10-30T12:17:49Z",
      "native_id": "10.1016/j.isci.2026.117888",
      "source": "crossref",
      "url": "https://linkinghub.elsevier.com/retrieve/pii/S2589004226032712"
    },
    {
      "first_seen": "2026-10-30T12:21:18Z",
      "native_id": "MED:42927188",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42927188"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "heading:Cell biology",
      "subfield": "cell-biology"
    }
  ],
  "title": "The smooth muscle titin filament system regulates uterus contractility and implantation",
  "title_text": "The smooth muscle titin filament system regulates uterus contractility and implantation",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:21:18Z",
  "url": "https://research.draconitic.com/paper/2gn06q26vzxp3",
  "venue": "iScience",
  "versions": []
}