{
  "abstract": "Aneurysmal fibrous histiocytoma (AFH) is generally a benign soft tissue tumor that most commonly occurs in the extremities and trunk. However, its primary presentation in the breast is exceedingly rare. Within this exceptionally rare subset, only isolated case reports have described recurrent AFH with malignant features. Here, we present a case of recurrent aneurysmal fibrous histiocytoma with malignant features occurring in the breast. Following recurrence, a 73-year-old female underwent modified radical mastectomy. Based on the histopathological and immunohistochemical evaluation of the resected specimen, combined with imaging findings, a final diagnosis of undifferentiated pleomorphic sarcoma (UPS) was established. The tumor in this case exhibited an immunophenotype positive for CD34, CD63, and CD68, with a Ki-67 index of approximately 30%, and harbored BCOR and ARID1A gene mutations. We discuss the histologic, immunohistochemical, and molecular findings that supported the diagnosis of UPS and consider whether this recurrent tumor represents progression from the earlier AFH.",
  "abstract_shown": true,
  "affiliations": [
    "Shandong First Medical University (Shandong Academy of Medical Sciences)",
    "Department of General Surgery, The First Affiliated Hospital of Shandong First Medical University",
    "Key Laboratory of Laparoscopic Technology, The First Affiliated Hospital of Shandong First Medical University",
    "Key Laboratory of Metabolism and Gastrointestinal Tumor, The First Affiliated Hospital of Shandong First Medical University"
  ],
  "article_type": "case report",
  "arxiv": null,
  "author_total": 4,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Kui Xiao"
    },
    {
      "affs": [
        1
      ],
      "name": "Nianqu Zhang"
    },
    {
      "affs": [
        1
      ],
      "name": "Qing Li"
    },
    {
      "affs": [
        1,
        2,
        3
      ],
      "name": "Qiaoran Liu"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/2gshmsw1x42ff.bib",
  "cited_by": 0,
  "doi": "10.3389/fonc.2026.1899426",
  "fulltext_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13724546/?tool=EBI",
  "id": "2gshmsw1x42ff",
  "issns": [
    "2234-943X"
  ],
  "landing_url": "https://www.frontiersin.org/articles/10.3389/fonc.2026.1899426/full",
  "language": "eng",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Case Report"
    ],
    [
      "openalex",
      "2740|Sarcoma Diagnosis and Treatment"
    ]
  ],
  "openalex": "W7222972761",
  "pdf_url": "https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2026.1899426/pdf",
  "pmcid": "PMC13724546",
  "pmid": "42973843",
  "published": "2026-10-19",
  "publisher": "Frontiers Media SA",
  "ris": "https://research.draconitic.com/paper/2gshmsw1x42ff.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:20:13Z",
      "native_id": "10.3389/fonc.2026.1899426",
      "source": "crossref",
      "url": "https://www.frontiersin.org/articles/10.3389/fonc.2026.1899426/full"
    },
    {
      "first_seen": "2026-11-03T15:20:51Z",
      "native_id": "PMC:PMC13724546",
      "source": "europepmc",
      "url": "https://europepmc.org/article/PMC/PMC13724546"
    },
    {
      "first_seen": "2026-11-04T12:23:06Z",
      "native_id": "PMC13724546",
      "source": "pmc",
      "url": "https://doi.org/10.3389/fonc.2026.1899426"
    },
    {
      "first_seen": "2026-11-04T15:20:48Z",
      "native_id": "MED:42973843",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42973843"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "issn:2234-943X",
      "subfield": "oncology"
    }
  ],
  "title": "Recurrent aneurysmal fibrous histiocytoma of the breast with malignant features: a rare case report",
  "title_text": "Recurrent aneurysmal fibrous histiocytoma of the breast with malignant features: a rare case report",
  "type": "peer-reviewed",
  "updated_at": "2026-11-06T12:20:59Z",
  "url": "https://research.draconitic.com/paper/2gshmsw1x42ff",
  "venue": "Frontiers in Oncology",
  "versions": []
}