{
  "abstract": "Objectives: To evaluate the impact of hyperbaric oxygen therapy on graft maturation and integration in patients undergoing anterior cruciate ligament (ACL) reconstruction, using magnetic resonance imaging (MRI) performed 4 months postoperatively. Methods: Patients who underwent primary anatomic ACL reconstruction with hamstring autografts and adjunctive hyperbaric oxygen therapy were identified and matched 1:1 by sex and age categories (<25, 25–39, 40–54, and >55 years) with controls who did not receive hyperbaric oxygen therapy. MRI was performed at 4 months postoperatively. Graft maturation was assessed using the signal-to-noise quotient (SNQ), and bone marrow edema adjacent to the graft–bone tunnel interface was graded as absent, mild, or accentuated as an indirect marker of graft integration. Results: A total of 52 patients were included (26 hyperbaric oxygen therapy, 26 controls), with a mean age of 37.0 ± 13.5 years and 61.5% male. The hyperbaric oxygen therapy group demonstrated significantly lower graft SNQ compared with controls (median difference = 83.9; p = 0.031), indicating improved graft maturation. Bone marrow edema adjacent to the graft–bone tunnel interface was also significantly lower in the hyperbaric oxygen therapy group (p = 0.029), suggesting enhanced graft integration. Conclusion: Hyperbaric oxygen therapy following ACL reconstruction was associated with significantly improved early signs of graft maturation and integration on MRI at 4 months, suggesting that it may accelerate the early phases of graft healing.",
  "abstract_shown": true,
  "affiliations": [
    "IOT HCFMUSP, SÃO PAULO - SP – BRASIL",
    "INSTITUTO VITA, SÃO PAULO - SP – BRASIL",
    "FLEURY MEDICINA E SAÚDE, SÃO PAULO - SP - BRASIL"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 6,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "C.B.G. Leite"
    },
    {
      "affs": [
        1
      ],
      "name": "D. Meirelles"
    },
    {
      "affs": [
        2
      ],
      "name": "L.R. Morimoto"
    },
    {
      "affs": [
        2
      ],
      "name": "A.G. Ormond Filho"
    },
    {
      "affs": [
        1
      ],
      "name": "C.O.D. Elia"
    },
    {
      "affs": [
        0
      ],
      "name": "M.K. Demange"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/2gstf7cjm7h01.bib",
  "cited_by": 0,
  "doi": "10.1177/2325967126s00621",
  "fulltext_url": "https://doi.org/10.1177/2325967126S00621",
  "id": "2gstf7cjm7h01",
  "issns": [
    "2325-9671"
  ],
  "landing_url": "https://doi.org/10.1177/2325967126s00621",
  "language": "en",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "lcc",
      "RC1200-1245"
    ],
    [
      "openalex",
      "2746|Knee injuries and reconstruction techniques"
    ]
  ],
  "openalex": "W7224089525",
  "pdf_url": "https://journals.sagepub.com/doi/pdf/10.1177/2325967126S00621?download=true",
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-28",
  "publisher": "SAGE Publishing",
  "ris": "https://research.draconitic.com/paper/2gstf7cjm7h01.ris",
  "sources": [
    {
      "first_seen": "2026-10-31T14:22:19Z",
      "native_id": "042d552d62c84779b73efd566d2307bb",
      "source": "doaj",
      "url": "https://doi.org/10.1177/2325967126s00621"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2746|Knee injuries and reconstruction techniques",
      "subfield": "surgery"
    }
  ],
  "title": "Hyperbaric Oxygen Therapy Improves Early Graft Healing Following ACL Reconstruction with Hamstring Autografts",
  "title_text": "Hyperbaric Oxygen Therapy Improves Early Graft Healing Following ACL Reconstruction with Hamstring Autografts",
  "type": "peer-reviewed",
  "updated_at": "2026-10-31T14:22:19Z",
  "url": "https://research.draconitic.com/paper/2gstf7cjm7h01",
  "venue": "Orthopaedic Journal of Sports Medicine",
  "versions": []
}