{
  "abstract": "Wet adhesives that perform under water have broad applications in industrial and biomedical settings. To date, molecular designs for underwater adhesives have largely been inspired by marine animals including mussels and barnacles. Here, we propose bacterial biofilms as an alternative source of inspiration for underwater adhesives. Specifically, we demonstrate the application potential of a peptide derived from biofilms formed by the notorious pathogen Vibrio cholerae. We characterize the ability of this biofilm-derived peptide to adsorb onto various surfaces and to glue wet surfaces by using a combination of confocal microscopy, molecular dynamics simulations, atomic force microscopy, lap shear tests, and spectroscopic tools. We further show that the peptide can coaggregate with microspheres acting as an effective flocculant. Our results open new design possibilities for underwater adhesives inspired by natural biofilms.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, CT 06511, USA.",
    "Department of Chemistry, Yale University, New Haven, CT 06520, USA.",
    "Department of Molecular Biology and Biochemistry, Molecular Biophysics Program, Wesleyan University, Middletown, CT 06459, USA.",
    "Department of Chemistry, University of Illinois Chicago, Chicago, IL 60607, USA.",
    "National Institute of Standards and Technology, Gaithersburg, MD 20899, USA.",
    "A. James Clark School of Engineering, University of Maryland, College Park, MD 20742, USA.",
    "Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT 06511, USA.",
    "Microbial Sciences Institute, Yale University, West Haven, CT 06516, USA.",
    "Department of Chemical and Materials Engineering, University of California Merced, Merced, CA 95344, USA.",
    "Department of Physics, University of Illinois Chicago, Chicago, IL 60607, USA.",
    "Quantitative Biology Institute, Yale University, New Haven, CT 06511, USA."
  ],
  "article_type": "Research Article",
  "arxiv": null,
  "author_total": 16,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Xin Huang",
      "orcid": "0000-0003-1745-8598"
    },
    {
      "affs": [
        0,
        2
      ],
      "name": "Ewelina D. Liszczyk",
      "orcid": "0009-0001-5177-1476"
    },
    {
      "affs": [
        3
      ],
      "name": "Ramesh Prasad",
      "orcid": "0000-0001-9184-779X"
    },
    {
      "affs": [
        4,
        5
      ],
      "name": "Megan E. Mitchell",
      "orcid": "0000-0001-8649-0562"
    },
    {
      "affs": [
        1
      ],
      "name": "Zhijie Wang",
      "orcid": "0000-0003-3160-4811"
    },
    {
      "affs": [
        0
      ],
      "name": "Yuchu Liu"
    },
    {
      "affs": [
        0
      ],
      "name": "Sarvagya Saluja",
      "orcid": "0000-0002-7860-7836"
    },
    {
      "affs": [
        2
      ],
      "name": "Mingyu Wang",
      "orcid": "0009-0000-4917-9994"
    },
    {
      "affs": [
        1
      ],
      "name": "Rebekah A. Jackson",
      "orcid": "0000-0002-9195-3186"
    },
    {
      "affs": [
        6,
        7
      ],
      "name": "Peter Dahl",
      "orcid": "0000-0002-9551-4455"
    },
    {
      "affs": [
        8
      ],
      "name": "Roberto Andresen Eguiluz",
      "orcid": "0000-0002-5209-4112"
    },
    {
      "affs": [
        6,
        7
      ],
      "name": "Nikhil Malvankar",
      "orcid": "0000-0001-5611-6633"
    },
    {
      "affs": [
        1
      ],
      "name": "Elsa C. Y. Yan",
      "orcid": "0000-0002-3583-1627"
    },
    {
      "affs": [
        2
      ],
      "name": "Rich Olson",
      "orcid": "0000-0002-5432-206X"
    },
    {
      "affs": [
        3,
        9
      ],
      "name": "Huan-Xiang Zhou",
      "orcid": "0000-0001-9020-0302"
    },
    {
      "affs": [
        0,
        10
      ],
      "name": "Jing Yan",
      "orcid": "0000-0003-2773-0348"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/2gyrb6n1h27e5.bib",
  "cited_by": 0,
  "doi": "10.1126/sciadv.aei1795",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13733808/",
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  "language": "en",
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    [
      "heading",
      "Materials Science"
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  "pmcid": "PMC13733808",
  "pmid": "42981400",
  "published": "2026-11-04",
  "publisher": "American Association for the Advancement of Science (AAAS)",
  "ris": "https://research.draconitic.com/paper/2gyrb6n1h27e5.ris",
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  "subjects": [
    {
      "field": "chemistry",
      "origin": "heading:Materials Science",
      "subfield": "materials-polymers"
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  "title": "A biofilm-derived peptide as an underwater adhesive",
  "title_text": "A biofilm-derived peptide as an underwater adhesive",
  "type": "peer-reviewed",
  "updated_at": "2026-11-08T12:23:31Z",
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