{
  "abstract": "This project addresses the challenge of controlling Dermanyssus gallinae infestations in poultry farms. A cohort-based model is developed that couples the pharmacokinetics of Fluralaner (Exzolt ®) in the plasma of laying hens with the dynamics of the mites, enabling the simulation of various treatment administration strategies while balancing costs. The study reveals that administering a reduced dose of Fluralaner (Exzolt ®) at high frequencies, in conjunction with a customized infestation tolerance threshold for each farm, provides a cost-effective solution for mite control. Specifically, this approach offers significant savings, with up to a 14,15% reduction in treatment costs in a case study involving moderate infestation levels. The findings emphasize that, in many cases, maintaining mite populations below acceptable limits is more economical than complete eradication. This research contributes to advancing poultry farm management practices and optimizing profitability.",
  "abstract_shown": true,
  "affiliations": [
    "École Nationale de Médecine Vétérinaire, Institution de la Recherche et de l'Enseignement Supérieur Agricoles, Université de la Manouba, Sidi Thabet, Tunisia.",
    "Laboratoire de bio-(informatique, mathématiques et statistique), Institut Pasteur de Tunis, Université Tunis El-Manar, Tunis, Tunisia.",
    "Laboratoire de recherche Ressources Génétiques Animales et Alimentaires (RGAA), Département des Productions Animales, Institut National Agronomiques de Tunisie, Université de Carthage & Institution de la Recherche et de l'Enseignement Supérieur Agricoles, Tunis, Tunisia.",
    "École Nationale d'Ingénieurs de Tunis, Université Tunis El-Manar, Tunis, Tunisia.",
    "Laboratoire de Recherche Epidemiologie des infections enzootiques des herbivores en Tunisie: application à la lutte (LR02AGR03), Sidi Thabet, Tunisia."
  ],
  "article_type": "Research Article",
  "arxiv": null,
  "author_total": 4,
  "authors": [
    {
      "affs": [
        0,
        1,
        2
      ],
      "name": "Maroua Bettaieb",
      "orcid": "0009-0002-1772-9132"
    },
    {
      "affs": [
        1,
        3
      ],
      "name": "Ahmed Louhichi"
    },
    {
      "affs": [
        0,
        4
      ],
      "name": "Mohamed Aziz Darghouth"
    },
    {
      "affs": [
        1
      ],
      "name": "Slimane Ben Miled"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/2h6hk7w6ff08w.bib",
  "cited_by": 0,
  "doi": "10.1371/journal.pone.0357723",
  "fulltext_url": "https://europepmc.org/articles/PMC13686290",
  "id": "2h6hk7w6ff08w",
  "issns": [
    "1932-6203"
  ],
  "landing_url": "https://doi.org/10.1371/journal.pone.0357723",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2405|Bird parasitology and diseases"
    ],
    [
      "plos",
      "/Biology and life sciences/Anatomy/Body fluids/Blood"
    ],
    [
      "plos",
      "/Biology and life sciences/Developmental biology/Life cycles/Nymphs"
    ],
    [
      "plos",
      "/Biology and life sciences/Organisms/Eukaryota/Animals/Invertebrates/Arthropoda/Mites"
    ],
    [
      "plos",
      "/Biology and life sciences/Organisms/Eukaryota/Animals/Vertebrates/Amniotes/Birds/Poultry"
    ],
    [
      "plos",
      "/Biology and life sciences/Physiology/Body fluids/Blood"
    ],
    [
      "plos",
      "/Biology and life sciences/Physiology/Reproductive physiology/Eggs/Bird eggs/Chicken eggs"
    ],
    [
      "plos",
      "/Biology and life sciences/Population biology/Population dynamics"
    ],
    [
      "plos",
      "/Biology and life sciences/Zoology/Animals/Invertebrates/Arthropoda/Mites"
    ],
    [
      "plos",
      "/Biology and life sciences/Zoology/Animals/Vertebrates/Amniotes/Birds/Poultry"
    ],
    [
      "plos",
      "/Medicine and health sciences/Anatomy/Body fluids/Blood"
    ],
    [
      "plos",
      "/Medicine and health sciences/Pharmacology/Pharmacokinetics"
    ],
    [
      "plos",
      "/Physical sciences/Mathematics/Optimization"
    ]
  ],
  "openalex": "W7223086599",
  "pdf_url": "https://europepmc.org/articles/PMC13686290?pdf=render",
  "pmcid": "PMC13686290",
  "pmid": "42905775",
  "published": "2026-10-21",
  "publisher": "Public Library of Science",
  "ris": "https://research.draconitic.com/paper/2h6hk7w6ff08w.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:23Z",
      "native_id": "10.1371/journal.pone.0357723",
      "source": "plos",
      "url": "https://doi.org/10.1371/journal.pone.0357723"
    },
    {
      "first_seen": "2026-10-30T12:19:53Z",
      "native_id": "MED:42905775",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42905775"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "plos:zoology",
      "subfield": "zoology-behaviour"
    },
    {
      "field": "medicine",
      "origin": "plos:anatomy",
      "subfield": "physiology"
    }
  ],
  "title": "A cohort-based population model for the Poultry Red Mite Dermanyssus gallinae (Acari: Dermanyssidae): Application to explore potential pathways for control strategies using Fluralaner as a case study",
  "title_text": "A cohort-based population model for the Poultry Red Mite Dermanyssus gallinae (Acari: Dermanyssidae): Application to explore potential pathways for control strategies using Fluralaner as a case study",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:19:53Z",
  "url": "https://research.draconitic.com/paper/2h6hk7w6ff08w",
  "venue": "PLOS One",
  "versions": []
}