{
  "abstract": "Sarcopenia is an age-related disease characterized by progressive loss of muscle mass and strength, leading to functional decline and frailty. Although high-intensity resistance training effectively improves these disorders, it is often unsuitable for older or frail individuals. This study investigated whether low-intensity resistance training combined with blood-flow restriction improves muscle function, morphology, and metabolism in a rat model of sarcopenia induced by ovariectomy and dexamethasone. A total of 44 female rats were studied, including a normal control group (NC, n = 8) and four model-based groups: sarcopenia model (SM, n = 8), blood-flow restriction (BFR, n = 8), low-intensity resistance training (LI-RT, n = 10), and combined low-intensity resistance training with blood-flow restriction (LRB, n = 10). Metabolomic profiling based on combined criteria of VIP > 1.0, FDR q < 0.05, and fold change > 1.2 or < 0.83 identified 72, 102, and 119 differential metabolites in the NC vs. SM, SM vs. LRB, and NC vs. LRB comparisons, respectively, and revealed that treated rats exhibited a metabolic shift toward the healthy phenotype. After 8 weeks of intervention, functional assessments, histological analyses, and untargeted metabolomics were performed. LRB produced the greatest improvements in grip strength, rotarod performance, and muscle indices, and increased muscle-fiber size without changing fiber number, indicating hypertrophy. Metabolomic profiling further showed a shift toward a healthier metabolic phenotype, with changes in amino acid and phospholipid pathways, including arginine–proline, glycine–serine–threonine, and choline metabolism. These findings indicate that low-intensity resistance training combined with blood-flow restriction improves muscle strength and morphology in sarcopenia and may act through coordinated metabolic remodeling.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 10,
  "authors": [
    {
      "name": "Jichao Huang"
    },
    {
      "name": "Yaozheng Wang"
    },
    {
      "name": "Teng Lou"
    },
    {
      "name": "Yuanpeng Liao"
    },
    {
      "name": "Yu Xia"
    },
    {
      "name": "Zhe Wang"
    },
    {
      "name": "Ziyu Zuo"
    },
    {
      "name": "Lina Zhou"
    },
    {
      "name": "Yan Zheng"
    },
    {
      "name": "Weirui Cheng"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/2h7p3xfd8hjzp.bib",
  "cited_by": 0,
  "doi": "10.1038/s41598-026-67823-0",
  "fulltext_url": null,
  "id": "2h7p3xfd8hjzp",
  "issns": [
    "2045-2322"
  ],
  "landing_url": "https://www.nature.com/articles/s41598-026-67823-0",
  "language": null,
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0",
  "metadata_licence": null,
  "native_subjects": [],
  "openalex": null,
  "pdf_url": "https://www.nature.com/articles/s41598-026-67823-0.pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-11-09",
  "publisher": "Springer Science and Business Media LLC",
  "ris": "https://research.draconitic.com/paper/2h7p3xfd8hjzp.ris",
  "sources": [
    {
      "first_seen": "2026-11-09T12:20:31Z",
      "native_id": "10.1038/s41598-026-67823-0",
      "source": "crossref",
      "url": "https://www.nature.com/articles/s41598-026-67823-0"
    }
  ],
  "subjects": [],
  "title": "Low-intensity resistance training with blood-flow restriction improves muscle function and activates amino acid and phospholipid metabolism in sarcopenia rat",
  "title_text": "Low-intensity resistance training with blood-flow restriction improves muscle function and activates amino acid and phospholipid metabolism in sarcopenia rat",
  "type": "peer-reviewed",
  "updated_at": "2026-11-10T00:20:59Z",
  "url": "https://research.draconitic.com/paper/2h7p3xfd8hjzp",
  "venue": "Scientific Reports",
  "versions": []
}