{
  "abstract": "Rabson-Mendenhall syndrome (RMS) is a rare autosomal recessive disorder caused by mutations in the insulin receptor gene (INSR), resulting in severe insulin resistance. We report the case of an 8-year-old boy who presented with progressive acanthosis nigricans of the neck, coarse facial features, generalized hypertrichosis, dental abnormalities, a fissured tongue, thickened nails, penile hypertrophy, and hepatomegaly. Laboratory results indicated hyperinsulinemia, severe insulin resistance and fasting hypoglycemia. Based on the clinical and laboratory findings, Rabson-Mendenhall syndrome was considered. Genetic confirmation was not performed because it was unavailable in our country. This case highlights the importance of recognizing acanthosis nigricans as a clinical marker of inherited metabolic syndromes, and the important role of dermatologists in its early recognition.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Dermatology, Faculty of Medicine, Damascus University, Damascus, Syria.",
    "Department of Pediatrics, Faculty of Medicine, Damascus University, Damascus, Syria."
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 5,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Mira Akhras",
      "orcid": "0009-0003-2563-2637"
    },
    {
      "affs": [
        0
      ],
      "name": "Mohammad Hmaidan"
    },
    {
      "affs": [
        0
      ],
      "name": "Rahaf Ghazal"
    },
    {
      "affs": [
        1
      ],
      "name": "Asad Alebrahem"
    },
    {
      "affs": [
        0
      ],
      "name": "Nemat Alsaghir"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/2hjskf32phfkt.bib",
  "cited_by": 0,
  "doi": "10.1093/omcr/omag199",
  "fulltext_url": "https://europepmc.org/articles/PMC13695952",
  "id": "2hjskf32phfkt",
  "issns": [
    "2053-8855"
  ],
  "landing_url": "https://europepmc.org/article/MED/42928893",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2708|Skin Diseases and Diabetes"
    ]
  ],
  "openalex": "W7223554833",
  "pdf_url": "https://europepmc.org/articles/PMC13695952?pdf=render",
  "pmcid": "PMC13695952",
  "pmid": "42928893",
  "published": "2026-10-25",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/2hjskf32phfkt.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:21:18Z",
      "native_id": "MED:42928893",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42928893"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2708|Skin Diseases and Diabetes",
      "subfield": "general"
    }
  ],
  "title": "Probable Rabson-Mendenhall syndrome presenting with acanthosis nigricans: a case report.",
  "title_text": "Probable Rabson-Mendenhall syndrome presenting with acanthosis nigricans: a case report.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:21:18Z",
  "url": "https://research.draconitic.com/paper/2hjskf32phfkt",
  "venue": "Oxford medical case reports",
  "versions": []
}