{
  "abstract": "Background/objectives\n\nWe compared the prognostic performance of preoperative prognostic nutritional index (PNI) and Gustave Roussy Immune Score (GRIm-s) after curative-intent gastrectomy.Methods\n\nThis retrospective cohort included 168 patients, including five postoperative in-hospital deaths. Continuous PNI and ordinal GRIm-s were compared using censoring-adjusted time-dependent AUC and concordance, with paired bootstrap confidence intervals. Preoperative prediction models underwent bootstrap internal validation; restricted mean survival time and time-varying Cox analyses addressed non-proportional hazards.Results\n\nThere were 92 deaths and 107 disease-free survival (DFS) events. At 36 months, overall survival (OS) AUC was 0.659 for PNI and 0.527 for GRIm-s (difference 0.132, 95% CI 0.039-0.226); corresponding DFS values were 0.650 and 0.516 (difference 0.134, 95% CI 0.035-0.228). After optimism correction, preoperative PNI-model AUCs were 0.610 for OS and 0.595 for DFS. PNI associations weakened over time. The cohort-derived 49.6 threshold was used only in secondary exploratory analyses.Conclusions\n\nPNI showed better unadjusted discrimination than GRIm-s at three years, but modest internally validated model performance limits clinical interpretation. These findings do not establish clinical utility, a validated cutoff, or a substitute for pathological assessment. External validation is required.",
  "abstract_shown": true,
  "affiliations": [
    "Department of General Surgery, Bağcılar Training and Research Hospital, University of Health Sciences, 34200 Istanbul, Türkiye.",
    "Department of General Surgery, Istanbul Aydın University, 34295 Istanbul, Türkiye."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 10,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Ahmet Sencer Ergin",
      "orcid": "0000-0001-6369-6146"
    },
    {
      "affs": [
        0
      ],
      "name": "Mustafa Can Alıklı"
    },
    {
      "affs": [
        0
      ],
      "name": "Ali Karabulut",
      "orcid": "0000-0001-6690-2152"
    },
    {
      "affs": [
        0
      ],
      "name": "Alparslan Saylar",
      "orcid": "0000-0001-6187-2556"
    },
    {
      "affs": [
        0
      ],
      "name": "Nihat Buğdaycı"
    },
    {
      "affs": [
        0
      ],
      "name": "Turan Pehlivan"
    },
    {
      "affs": [
        1
      ],
      "name": "Serhat Meriç"
    },
    {
      "affs": [
        0
      ],
      "name": "Ali Naki Yücesoy"
    },
    {
      "affs": [
        0
      ],
      "name": "Erkan Yavuz"
    },
    {
      "affs": [
        0
      ],
      "name": "Osman Bilgin Gülçiçek",
      "orcid": "0000-0001-5285-6909"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/2hmrxmfw2k77s.bib",
  "cited_by": 0,
  "doi": "10.3390/curroncol33100610",
  "fulltext_url": "https://europepmc.org/articles/PMC13702855",
  "id": "2hmrxmfw2k77s",
  "issns": [
    "1198-0052",
    "1718-7729"
  ],
  "landing_url": "https://europepmc.org/article/MED/42930177",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2730|Inflammatory Biomarkers in Disease Prognosis"
    ]
  ],
  "openalex": "W7221328323",
  "pdf_url": "https://europepmc.org/articles/PMC13702855?pdf=render",
  "pmcid": "PMC13702855",
  "pmid": "42930177",
  "published": "2026-10-10",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/2hmrxmfw2k77s.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:22:01Z",
      "native_id": "MED:42930177",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42930177"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2730|Inflammatory Biomarkers in Disease Prognosis",
      "subfield": "oncology"
    }
  ],
  "title": "Comparative Prognostic Value of the Preoperative Prognostic Nutritional Index and Gustave Roussy Immune Score After Curative-Intent Gastrectomy for Gastric Cancer.",
  "title_text": "Comparative Prognostic Value of the Preoperative Prognostic Nutritional Index and Gustave Roussy Immune Score After Curative-Intent Gastrectomy for Gastric Cancer.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:22:01Z",
  "url": "https://research.draconitic.com/paper/2hmrxmfw2k77s",
  "venue": "Current oncology (Toronto, Ont.)",
  "versions": []
}