{
  "abstract": "Triglyceride-rich lipoproteins (TRL) and lipoprotein(a) [Lp(a)] demonstrate heightened per-particle atherogenicity compared with low-density lipoproteins (LDL), yet mechanistic underpinnings remain unclear. Using Mendelian randomization in >46,000 UK Biobank participants, we linked genetically determined variation in TRL/remnants, LDL, and Lp(a) to 2,920 plasma proteins and found causal associations with 432, 58, and 111 proteins, respectively. Notably, TRL/remnants and Lp(a) both impacted chemokine-signaling and leukocyte-chemotaxis pathways, distinct from LDL's effect on lipid metabolism. A specific chemokine signature linked to both TRL and Lp(a) accounted for around 40% (with wide confidence limits) of the TRL/remnant cholesterol: cardiovascular disease (CVD) association. However, a more general causal relationship between plasma chemokine concentrations and CVD risk independent of a TRL/Lp(a) effect was not supported by quantitative trait loci analysis. These results are compatible with a model in which TRL/Lp(a)-driven chemokine activation contributes meaningfully to CVD risk.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Molecular and Clinical Medicine, Institute of Medicine, University of Gothenburg, Gothenburg, Sweden. Electronic address: https://twitter.com/EliasBjornson.",
    "Department of Molecular and Clinical Medicine, Institute of Medicine, University of Gothenburg, Gothenburg, Sweden; School of Public Health and Community Medicine, Institute of Medicine, University of Gothenburg, Gothenburg, Sweden.",
    "Department of Life Sciences, SciLifeLab, Chalmers University of Technology, Gothenburg, Sweden.",
    "Department of Laboratory Medicine, Medical University of Vienna, Vienna, Austria.",
    "Department of Molecular and Clinical Medicine, Institute of Medicine, University of Gothenburg, Gothenburg, Sweden; Department of Clinical Genetics, Region Västra Götaland, Sahlgrenska University Hospital, Gothenburg, Sweden.",
    "Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, United Kingdom.",
    "Department of Molecular and Clinical Medicine, Institute of Medicine, University of Gothenburg, Gothenburg, Sweden. Electronic address: jan.boren@wlab.gu.se."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 9,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Elias Björnson",
      "orcid": "0000-0002-0003-6463"
    },
    {
      "affs": [
        1
      ],
      "name": "Martin Adiels"
    },
    {
      "affs": [
        2
      ],
      "name": "Jakub Morze"
    },
    {
      "affs": [
        3
      ],
      "name": "Florentina Porsch",
      "orcid": "0000-0002-2633-6632"
    },
    {
      "affs": [
        4
      ],
      "name": "Anders Gummesson"
    },
    {
      "affs": [
        3
      ],
      "name": "Christoph J Binder"
    },
    {
      "affs": [
        2
      ],
      "name": "Clemens Wittenbecher"
    },
    {
      "affs": [
        5
      ],
      "name": "Chris J Packard"
    },
    {
      "affs": [
        6
      ],
      "name": "Jan Borén"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/2hv8t0q6e414x.bib",
  "cited_by": 0,
  "doi": "10.1016/j.jacbts.2026.101736",
  "fulltext_url": "https://europepmc.org/articles/PMC13685006",
  "id": "2hv8t0q6e414x",
  "issns": [
    "2452-302X"
  ],
  "landing_url": "https://europepmc.org/article/MED/42868980",
  "language": "eng",
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2746|Lipoproteins and Cardiovascular Health"
    ]
  ],
  "openalex": "W7221716769",
  "pdf_url": "https://europepmc.org/articles/PMC13685006?pdf=render",
  "pmcid": "PMC13685006",
  "pmid": "42868980",
  "published": "2026-10-13",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/2hv8t0q6e414x.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:19:00Z",
      "native_id": "MED:42868980",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42868980"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2746|Lipoproteins and Cardiovascular Health",
      "subfield": "surgery"
    }
  ],
  "title": "A Chemokine Profile Linked to Both Triglyceride-Rich Lipoproteins and Lipoprotein(a), But Not LDL, Is Associated With Cardiovascular Disease.",
  "title_text": "A Chemokine Profile Linked to Both Triglyceride-Rich Lipoproteins and Lipoprotein(a), But Not LDL, Is Associated With Cardiovascular Disease.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:19:00Z",
  "url": "https://research.draconitic.com/paper/2hv8t0q6e414x",
  "venue": "JACC. Basic to translational science",
  "versions": []
}