{
  "abstract": "Here, we report a rare case of a 32-year-old patient presenting with a second episode of influenza A-triggered acute necrotizing encephalomyelitis (ANE) in the context of a Ran-binding protein 2 (RANBP2) -mutation, which was diagnosed after a previous influenza-triggered ANE at the age of eleven. Despite early treatment with corticosteroids, plasmapheresis and intravenous immunoglobulins (IVIG) no meaningful clinical improvement was observed during the first 6 weeks of treatment. As interleukin-6 (IL-6) levels were elevated in both blood and cerebrospinal fluid (CSF), additional therapy with tocilizumab was initiated, leading to clinical improvement from week 11 onward.",
  "abstract_shown": true,
  "affiliations": [
    "Division of Internal Medicine, University Hospital of Basel",
    "Department of Neurology, University Hospital and University of Basel",
    "Multiple Sclerosis Centre and Research Centre for Clinical Neuroimmunology and Neuroscience Basel (RC2NB), Department of Biomedicine and Clinical Research, University Hospital and University of Basel"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 8,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Marie-Anne Heusler"
    },
    {
      "affs": [
        1,
        2
      ],
      "name": "Sofia Sandgren"
    },
    {
      "affs": [
        1,
        2
      ],
      "name": "Jens Kuhle"
    },
    {
      "affs": [
        1
      ],
      "name": "Stephan Rüegg"
    },
    {
      "affs": [
        1,
        2
      ],
      "name": "Özgür Yaldizli"
    },
    {
      "affs": [
        1,
        2
      ],
      "name": "Cristina Granziera"
    },
    {
      "affs": [
        0
      ],
      "name": "Marten Trendelenburg"
    },
    {
      "affs": [
        0
      ],
      "name": "Severin Bausch"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/2hvc695aqdjgc.bib",
  "cited_by": 0,
  "doi": "10.3389/fimmu.2026.1866407",
  "fulltext_url": null,
  "id": "2hvc695aqdjgc",
  "issns": [
    "1664-3224"
  ],
  "landing_url": "https://www.frontiersin.org/articles/10.3389/fimmu.2026.1866407/full",
  "language": null,
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2725|Infectious Encephalopathies and Encephalitis"
    ]
  ],
  "openalex": "W7224099836",
  "pdf_url": "https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2026.1866407/pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-28",
  "publisher": "Frontiers Media SA",
  "ris": "https://research.draconitic.com/paper/2hvc695aqdjgc.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:19:17Z",
      "native_id": "10.3389/fimmu.2026.1866407",
      "source": "crossref",
      "url": "https://www.frontiersin.org/articles/10.3389/fimmu.2026.1866407/full"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2725|Infectious Encephalopathies and Encephalitis",
      "subfield": "infectious-disease"
    }
  ],
  "title": "A case report of influenza-triggered RANBP2-associated acute necrotizing encephalomyelitis in an adult successfully treated with tocilizumab",
  "title_text": "A case report of influenza-triggered RANBP2-associated acute necrotizing encephalomyelitis in an adult successfully treated with tocilizumab",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:19:17Z",
  "url": "https://research.draconitic.com/paper/2hvc695aqdjgc",
  "venue": "Frontiers in Immunology",
  "versions": []
}