{
  "abstract": "Objective: To systematically evaluate the efficacy and safety of glucocorticoids as adjuvant therapy for Pneumocystis pneumonia (PCP) in patients positive for human immunodeficiency virus (HIV).\n\nMethods: Clinical randomized controlled trials or clinical controlled trials evaluating the efficacy and safety of glucocorticoids as adjuvant therapy for PCP in patients who are HIV-positive were retrieved from PubMed, Embase, Web of Science, and the Cochrane Library. Data extraction and methodological quality assessment were performed for eligible studies. Meta-analysis and systematic evaluation were conducted using RevMan v.5.1 and STATA v.12.0 software.\n\nResults: Nine articles (13 studies) were included. Compared with the controls, patients treated with glucocorticoids had significantly lower mortality rates (OR = 0.41, 95% CI [0.28–0.59], P < 0.00001), early deterioration rates (OR = 0.08, 95% CI [0.02–0.39], P = 0.002), and lower mechanical ventilation rates (OR = 0.32, 95% CI [0.19–0.55], P < 0.0001). Regarding safety, the incidence of adverse effects did not differ significantly between the two groups (OR = 0.74, 95% CI [0.33–1.70], P = 0.48).\n\nConclusion: Adjuvant glucocorticoid therapy significantly reduces mortality, early deterioration, and mechanical ventilation rates in patients who are HIV-positive with PCP without increasing adverse reactions. Glucocorticoids may serve as a viable adjuvant treatment option for PCP in patients who are HIV-positive.\n\nSystematic Review Registration: https://www.crd.york.ac.uk/PROSPERO/home , identifier CRD420261418795.",
  "abstract_shown": true,
  "affiliations": [
    "Beijing Anzhen Nanchong Hospital of Capital Medical University & Nanchong Central Hospital",
    "The Affiliated Hospital of North Sichuan Medical College",
    "Nanchong Key Laboratory of Individualized Drug Therapy",
    "Xiamen Humanity Hospital"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 6,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Zhiyong Tang"
    },
    {
      "affs": [
        1
      ],
      "name": "Rui Li"
    },
    {
      "affs": [
        0,
        2
      ],
      "name": "Xiaoying Chen"
    },
    {
      "affs": [
        0,
        2
      ],
      "name": "Qiang Su"
    },
    {
      "affs": [
        1
      ],
      "name": "Bin Han"
    },
    {
      "affs": [
        3
      ],
      "name": "Ming Yang"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/2j589pzk80wrh.bib",
  "cited_by": 0,
  "doi": "10.3389/fphar.2026.1916907",
  "fulltext_url": null,
  "id": "2j589pzk80wrh",
  "issns": [
    "1663-9812"
  ],
  "landing_url": "https://www.frontiersin.org/articles/10.3389/fphar.2026.1916907/full",
  "language": null,
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2713|Pneumocystis jirovecii pneumonia detection and treatment"
    ]
  ],
  "openalex": "W7224098853",
  "pdf_url": null,
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-28",
  "publisher": "Frontiers Media SA",
  "ris": "https://research.draconitic.com/paper/2j589pzk80wrh.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:20:06Z",
      "native_id": "10.3389/fphar.2026.1916907",
      "source": "crossref",
      "url": "https://www.frontiersin.org/articles/10.3389/fphar.2026.1916907/full"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2713|Pneumocystis jirovecii pneumonia detection and treatment",
      "subfield": "epidemiology-public-health"
    }
  ],
  "title": "Efficacy and safety of adjuvant glucocorticoid therapy for Pneumocystis pneumonia (PCP) in patients positive for HIV: a systematic review and meta-analysis",
  "title_text": "Efficacy and safety of adjuvant glucocorticoid therapy for Pneumocystis pneumonia (PCP) in patients positive for HIV: a systematic review and meta-analysis",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:20:06Z",
  "url": "https://research.draconitic.com/paper/2j589pzk80wrh",
  "venue": "Frontiers in Pharmacology",
  "versions": []
}