{
  "abstract": "Zinc ions (Zn2+) can induce immune response through activating pyroptosis and cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) pathway, and disrupting the intracellular redox balance is an important strategy for enhancing Zn2+-driven immunotherapy. Herein, using bimetallic manganese platinum (MnPt) nanozyme as the core, a multifunctional MnPt@ZIF-8/β-Lap@F-127 nanozyme with multi-enzyme activity was developed by coating metal-organic framework (ZIF-8), carrying β-Lapachone (β-Lap) and modifying F-127 and the Zn2+-induced immunotherapy was enhanced through photothermal/catalytic dual-strategy. The MnPt@ZIF-8/β-Lap@F-127 nanozyme has the glutathione peroxidase/peroxidase/catalase-like activity, and the photothermal and photoacoustic imaging properties. Under acidic microenvironment, the MnPt@ZIF-8/β-Lap@F-127 nanozyme was degraded, and the Zn2+ and β-Lap were released. By producing a large amount of reactive oxygen species, the MnPt@ZIF-8/β-Lap@F-127 nanozyme induced apoptosis and pyroptosis, and activated the cGAS-STING pathway. Under the dual action of photothermal/catalytic, the mitochondrial function was destroyed and the damage-associated molecular patterns were released, effectively triggering the immunogenic cell death. By improving the immune cells infiltration and pro-inflammatory factors level and reducing the immunosuppressive cells proportion, the MnPt@ZIF-8/β-Lap@F-127 nanozyme greatly inhibited the primary tumor growth and lung metastasis, which demonstrated that the MnPt@ZIF-8/β-Lap@F-127 nanozyme remodeled the immune microenvironment and enhanced the Zn2+-induced immunotherapy.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 9,
  "authors": [
    {
      "name": "Zekai Li"
    },
    {
      "name": "Qi Zhao"
    },
    {
      "name": "Liye Wang"
    },
    {
      "name": "Zhou Shen"
    },
    {
      "name": "Feng Liu"
    },
    {
      "name": "Jiamei Ma"
    },
    {
      "name": "Lining Zhao",
      "orcid": "0000-0003-0311-7856"
    },
    {
      "name": "Xiaoping Yin"
    },
    {
      "name": "Leyong Zeng",
      "orcid": "0000-0002-1127-2066"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/2jaqg5pkz0hj3.bib",
  "cited_by": 0,
  "doi": "10.1093/rb/rbag210",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13725651/",
  "id": "2jaqg5pkz0hj3",
  "issns": [
    "2056-3418",
    "2056-3426"
  ],
  "landing_url": "https://doi.org/10.1093/rb/rbag210",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "AcademicSubjects/MED00010"
    ],
    [
      "heading",
      "AcademicSubjects/SCI01410"
    ],
    [
      "heading",
      "Research Article"
    ],
    [
      "openalex",
      "2204|Nanoplatforms for cancer theranostics"
    ]
  ],
  "openalex": "W7214061992",
  "pdf_url": "https://europepmc.org/articles/PMC13725651?pdf=render",
  "pmcid": "PMC13725651",
  "pmid": "42974226",
  "published": "2026-09-21",
  "publisher": "Oxford University Press",
  "ris": "https://research.draconitic.com/paper/2jaqg5pkz0hj3.ris",
  "sources": [
    {
      "first_seen": "2026-11-04T12:23:59Z",
      "native_id": "PMC13725651",
      "source": "pmc",
      "url": "https://doi.org/10.1093/rb/rbag210"
    },
    {
      "first_seen": "2026-11-04T15:20:49Z",
      "native_id": "MED:42974226",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42974226"
    }
  ],
  "subjects": [],
  "title": "MnPt@metal organic framework nanozyme with photothermal/catalytic dual-strategy enhances Zn2+-mediated immunotherapy through activating pyroptosis and cGAS-STING pathway",
  "title_text": "MnPt@metal organic framework nanozyme with photothermal/catalytic dual-strategy enhances Zn2+-mediated immunotherapy through activating pyroptosis and cGAS-STING pathway",
  "type": "peer-reviewed",
  "updated_at": "2026-11-06T12:21:50Z",
  "url": "https://research.draconitic.com/paper/2jaqg5pkz0hj3",
  "venue": "Regenerative Biomaterials",
  "versions": []
}