{
  "abstract": "Chagas disease is caused by infection with the protozoan parasite Trypanosoma cruzi . Despite triggering a strong immune response, infections are typically life-long and can result in severe cardiac and/or digestive tract pathology. Current drugs have limited efficacy, and treatment failure is a common outcome. Eliminating a non-replicating T. cruzi sub-population that can persist after therapy has been a key challenge for the drug-development community. Here, we describe the transcriptome and proteome profiles of a low-proliferative sub-population of epimastigote forms of the parasite isolated from exponentially growing cultures on the basis of reduced turnover of transiently-induced red fluorescent protein. This partially quiescent sub-population was characterised by down-regulation of genes/proteins involved in translation, transcription, metabolism, mitochondrial function and DNA replication, and by up-regulation of proteins that promote exit from the cell cycle in other organisms. Differential expression was considerably more pronounced at a protein than an RNA level. These data provide a resource that can be exploited to dissect the mechanistic basis of quiescence, as a step towards refining the drug-development screening cascade.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 14,
  "authors": [
    {
      "name": "Francisco Olmo",
      "orcid": "0000-0001-9314-0026"
    },
    {
      "name": "Amy Hesketh"
    },
    {
      "name": "Hayat Hage"
    },
    {
      "name": "Jean-Marc Monneuse",
      "orcid": "0009-0006-4511-5081"
    },
    {
      "name": "Martin C. Taylor",
      "orcid": "0000-0003-4147-0693"
    },
    {
      "name": "Fernanda C. Costa"
    },
    {
      "name": "Célie Da Silva",
      "orcid": "0009-0006-3712-3559"
    },
    {
      "name": "Frédéric Bequet"
    },
    {
      "name": "Fanny Escudié",
      "orcid": "0000-0002-9177-9755"
    },
    {
      "name": "Derry Mercer",
      "orcid": "0000-0001-8950-0076"
    },
    {
      "name": "Adrien Saliou"
    },
    {
      "name": "Eric Chatelain",
      "orcid": "0000-0002-3158-7743"
    },
    {
      "name": "John M. Kelly",
      "orcid": "0000-0003-4305-5258"
    },
    {
      "name": "Josephine Abi-Ghanem",
      "orcid": "0000-0002-8281-1266"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/2jrsp731jam58.bib",
  "cited_by": 0,
  "doi": "10.1038/s42003-026-11251-3",
  "fulltext_url": null,
  "id": "2jrsp731jam58",
  "issns": [
    "2399-3642"
  ],
  "landing_url": "https://www.nature.com/articles/s42003-026-11251-3",
  "language": null,
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [],
  "openalex": null,
  "pdf_url": null,
  "pmcid": null,
  "pmid": null,
  "published": "2026-11-03",
  "publisher": "Springer Science and Business Media LLC",
  "ris": "https://research.draconitic.com/paper/2jrsp731jam58.ris",
  "sources": [
    {
      "first_seen": "2026-11-04T00:21:36Z",
      "native_id": "10.1038/s42003-026-11251-3",
      "source": "crossref",
      "url": "https://www.nature.com/articles/s42003-026-11251-3"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "issn:2399-3642",
      "subfield": "general"
    }
  ],
  "title": "Transcriptomic and proteomic analysis of quiescent epimastigotes as a resource for investigating Trypanosoma cruzi persistence",
  "title_text": "Transcriptomic and proteomic analysis of quiescent epimastigotes as a resource for investigating Trypanosoma cruzi persistence",
  "type": "peer-reviewed",
  "updated_at": "2026-11-04T12:20:50Z",
  "url": "https://research.draconitic.com/paper/2jrsp731jam58",
  "venue": "Communications Biology",
  "versions": []
}