{
  "abstract": "Three discoveries contribute to understanding sex differences in blood pressure set-point: 1) females exhibit a greater natriuresis to acute hypertension (aHTN) than males; 2) aHTN provokes sex-specific molecular adaptations along the nephron: proximal NHE3 and NaPi2 redistribute in both sexes; medullary NHE3 and NKCC2 abundance are reduced in females, distal NCC abundance is reduced in males; 3) inhibition of arachidonic acid metabolites shifts renal function curves leftward in both sexes, and augments natriuresis in males.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Physiology and Neuroscience, Keck School of Medicine of USC, Los Angeles, CA",
    "Institute for Anatomy and Cell Biology, University of Würzburg, Würzburg, Germany",
    "Departments of Applied Mathematics and Biology, Cheriton School of Computer Science, and School of Pharmacology, University of Waterloo, Waterloo, Ontario, Canada"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 5,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Brandon E. McFarlin"
    },
    {
      "affs": [
        0
      ],
      "name": "Donna L. Ralph"
    },
    {
      "affs": [
        1
      ],
      "name": "Hermann Koepsell"
    },
    {
      "affs": [
        2
      ],
      "name": "Anita T. Layton"
    },
    {
      "affs": [
        0
      ],
      "name": "Alicia A. McDonough"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/2jrzndsnyxg94.bib",
  "cited_by": 0,
  "doi": "10.1152/ajpcell.00385.2026",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13696152/",
  "id": "2jrzndsnyxg94",
  "issns": [
    "0363-6143",
    "1522-1563"
  ],
  "landing_url": "https://doi.org/10.1152/ajpcell.00385.2026",
  "language": "en",
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Article"
    ],
    [
      "openalex",
      "2705|Blood Pressure and Hypertension Studies"
    ]
  ],
  "openalex": "W7204075852",
  "pdf_url": "https://journals.physiology.org/doi/pdf/10.1152/ajpcell.00385.2026?download=true",
  "pmcid": "PMC13696152",
  "pmid": "42636047",
  "published": "2026-08-24",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/2jrzndsnyxg94.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:33Z",
      "native_id": "PMC13696152",
      "source": "pmc",
      "url": "https://doi.org/10.1152/ajpcell.00385.2026"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2705|Blood Pressure and Hypertension Studies",
      "subfield": "cardiovascular"
    }
  ],
  "title": "Sexual dimorphisms in mechanisms of pressure natriuresis",
  "title_text": "Sexual dimorphisms in mechanisms of pressure natriuresis",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:33:32Z",
  "url": "https://research.draconitic.com/paper/2jrzndsnyxg94",
  "venue": "American journal of physiology. Cell physiology",
  "versions": []
}