{
  "abstract": "Objectives: The available measure to prevent Streptococcus agalactiae (Group B Streptococcus, GBS) neonatal infection is intrapartum antibiotic prophylaxis (IAP), but it is threatened by bacterial resistance. Therefore, this study aimed to investigate antimicrobial resistance and bacterial targets of vaccines at the most advanced stage of development.\n\nMethods: GBS isolates (n = 222) recovered from pregnant women between 2019 and 2024 were subjected to capsular polysaccharides and alpha‐like proteins investigation and antimicrobial susceptibility testing. Macrolide and fluoroquinolone resistance determinants and genetic diversity of multidrug‐resistant (MDR) isolates were also investigated.\n\nResults: The main capsular types were Ia (78, 35.1%), III (42, 18.9%), V (39, 17.6%) and II (32, 14.4%). Vaccines based on hexavalent capsular polysaccharides and alpha‐like proteins would have 97.3% and 87.5% of predicted efficacy, respectively. Isolates were categorized as not susceptible (NS), that is, intermediate and resistant, to levofloxacin (5, 2.3%), clindamycin (11, 5%), erythromycin (58, 26.1%) and tetracycline (171, 77%). Among erythromycin NS isolates, the M phenotype/mef(A) gene predominated (47, 81%). All levofloxacin‐resistant isolates showed amino acid substitutions in both GyrA (S81L) and ParC (S79F). MDR isolates (10, 4.5%) had distinct genetic backgrounds.\n\nConclusions: Both immunization approaches would be effective in the population. Although the elevated erythromycin resistance rate, one of the highest reported in the country, clindamycin remains an efficient option in IAP. MDR isolates have not resulted from the dissemination of a single clone, but instead showed a polyclonal origin.",
  "abstract_shown": true,
  "affiliations": [
    "Instituto Biomédico, Universidade Federal Fluminense Niterói Rio de Janeiro Brazil",
    "Instituto Fernandes Figueira, Fundação Oswaldo Cruz Rio de Janeiro Rio de Janeiro Brazil",
    "Hospital Universitário Antônio Pedro, Universidade Federal Fluminense Niterói Rio de Janeiro Brazil",
    "Faculdade de Farmácia Universidade Federal Fluminense Niterói Rio de Janeiro Brazil"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 6,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Clarissa Campos Barros",
      "orcid": "0009-0001-2646-7712"
    },
    {
      "affs": [
        1
      ],
      "name": "Fabíola C. Oliveira Kegele",
      "orcid": "0009-0001-8882-149X"
    },
    {
      "affs": [
        1
      ],
      "name": "Maria Francisca da S. N. Soares"
    },
    {
      "affs": [
        2
      ],
      "name": "Douglas Guedes Ferreira",
      "orcid": "0000-0002-9610-5100"
    },
    {
      "affs": [
        3
      ],
      "name": "Geraldo Renato de Paula",
      "orcid": "0000-0002-2748-1487"
    },
    {
      "affs": [
        0
      ],
      "name": "Rosana Rocha Barros",
      "orcid": "0000-0003-2440-7844"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/2k5nth5vp4vkm.bib",
  "cited_by": 0,
  "doi": "10.1111/tmi.70212",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13727695/",
  "id": "2k5nth5vp4vkm",
  "issns": [
    "1360-2276",
    "1365-3156"
  ],
  "landing_url": "https://doi.org/10.1111/tmi.70212",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Research Article"
    ],
    [
      "openalex",
      "2739|Neonatal and Maternal Infections"
    ]
  ],
  "openalex": "W7171865062",
  "pdf_url": null,
  "pmcid": "PMC13727695",
  "pmid": "42532504",
  "published": "2026-07-30",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/2k5nth5vp4vkm.ris",
  "sources": [
    {
      "first_seen": "2026-11-06T12:23:31Z",
      "native_id": "PMC13727695",
      "source": "pmc",
      "url": "https://doi.org/10.1111/tmi.70212"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2739|Neonatal and Maternal Infections",
      "subfield": "epidemiology-public-health"
    }
  ],
  "title": "Vaccine Targets and Antimicrobial Resistance of Streptococcus agalactiae Recovered From Pregnant Women in Brazil",
  "title_text": "Vaccine Targets and Antimicrobial Resistance of Streptococcus agalactiae Recovered From Pregnant Women in Brazil",
  "type": "peer-reviewed",
  "updated_at": "2026-11-07T12:20:50Z",
  "url": "https://research.draconitic.com/paper/2k5nth5vp4vkm",
  "venue": "Tropical Medicine & International Health",
  "versions": []
}