{
  "abstract": "Background/Objectives: Whether pre-stroke cardiovascular treatment is reflected in the early systemic hemodynamic phenotype after acute ischemic stroke (AIS) is uncertain. We examined associations between major medication classes, early impedance-cardiography measures, and 6-month mortality. Methods: This prospective multicenter cohort included 233 patients with AIS and available pre-stroke medication data. Hemodynamics were assessed within 24 h of hospital admission. Four drug–physiology pairs were prespecified: beta-blockers–heart rate, renin–angiotensin system inhibitors–systemic vascular resistance index (SVRI), calcium-channel blockers–SVRI, and loop/thiazide(-like) diuretics–thoracic fluid content (TFC). Because technical equivalence of absolute TFC output between acquisition platforms was not established, inferential TFC analyses were restricted to CardioScreen/Niccomo observations. Primary hemodynamic models used HC3 robust standard errors with Holm correction; mortality models used FDR correction. Results: Mean age was 73.7 ± 12.1 years, 53.2% were women, and median NIHSS was 7 [4–12]. None of the four primary associations was supported after Holm correction. Adjusted differences were +0.23 bpm for beta-blockers–heart rate, +192 dyn·s·cm−5·m2 for RAAS inhibitors–SVRI, +254 dyn·s·cm−5·m2 for calcium-channel blockers–SVRI, and −3.72 1/kΩ for diuretics–TFC in the CardioScreen/Niccomo-restricted analysis (nominal p = 0.013; Holm p = 0.053). No secondary association survived FDR correction (all q ≥ 0.406). Forty-seven of 208 patients (22.6%) died within 6 months; no medication class was independently associated with mortality (all q ≥ 0.711). Conclusions: Documented pre-stroke cardiovascular medication use was not robustly associated with the early systemic hemodynamic phenotype or adjusted 6-month mortality after AIS. Modest class-specific associations cannot be excluded.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Family Medicine, Medical University of Gdańsk, Dębinki 7, 80-211 Gdańsk, Poland",
    "Department of Orthopedics, Pediatric Orthopedics and Traumatology, Centre of Postgraduate Medical Education, 05-400 Otwock, Poland",
    "Department of Neurology, 7th Navy Hospital, 80-305 Gdańsk, Poland",
    "Department of Neurology, Medical University of Gdańsk, 80-214 Gdańsk, Poland",
    "Department of Work Physiology and Ergonomics, Nofer Institute of Occupational Medicine, 91-348 Łódź, Poland",
    "Division of Biostatistics and Neural Networks, Medical University of Gdańsk, 80-211 Gdańsk, Poland"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 9,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Piotr Gutknecht",
      "orcid": "0000-0003-0227-3128"
    },
    {
      "affs": [
        0
      ],
      "name": "Bartosz G. Trzeciak",
      "orcid": "0000-0002-8316-9826"
    },
    {
      "affs": [
        1
      ],
      "name": "Marek Tałałaj",
      "orcid": "0000-0003-2982-7936"
    },
    {
      "affs": [
        2
      ],
      "name": "Krzysztof Dziewiatowski",
      "orcid": "0000-0001-6393-6437"
    },
    {
      "affs": [
        2
      ],
      "name": "Grzegorz Wochyń"
    },
    {
      "affs": [
        3
      ],
      "name": "Walenty M. Nyka"
    },
    {
      "affs": [
        4
      ],
      "name": "Alicja Bortkiewicz",
      "orcid": "0000-0002-0042-4597"
    },
    {
      "affs": [
        5
      ],
      "name": "Dariusz Świetlik",
      "orcid": "0000-0002-9127-7368"
    },
    {
      "affs": [
        0
      ],
      "name": "Janusz Siebert"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/2k9g4qsbt5fyb.bib",
  "cited_by": 0,
  "doi": "10.3390/jcm15218386",
  "fulltext_url": null,
  "id": "2k9g4qsbt5fyb",
  "issns": [
    "2077-0383"
  ],
  "landing_url": "https://www.mdpi.com/2077-0383/15/21/8386",
  "language": null,
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2713|Acute Ischemic Stroke Management"
    ]
  ],
  "openalex": "W7224091780",
  "pdf_url": null,
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-28",
  "publisher": "MDPI AG",
  "ris": "https://research.draconitic.com/paper/2k9g4qsbt5fyb.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:20:01Z",
      "native_id": "10.3390/jcm15218386",
      "source": "crossref",
      "url": "https://www.mdpi.com/2077-0383/15/21/8386"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2713|Acute Ischemic Stroke Management",
      "subfield": "epidemiology-public-health"
    }
  ],
  "title": "Pre-Stroke Cardiovascular Pharmacotherapy and Early Systemic Hemodynamics After Acute Ischemic Stroke: A Prospective Multicenter Cohort Study",
  "title_text": "Pre-Stroke Cardiovascular Pharmacotherapy and Early Systemic Hemodynamics After Acute Ischemic Stroke: A Prospective Multicenter Cohort Study",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:20:01Z",
  "url": "https://research.draconitic.com/paper/2k9g4qsbt5fyb",
  "venue": "Journal of Clinical Medicine",
  "versions": []
}