{
  "abstract": "Background: Sensorineural hearing loss (SNHL) with vertigo causes substantial auditory and quality-of-life burden. We evaluated gastrodin acupoint injection (GAI) as an adjunct to conventional treatment. Methods: In this single-center open-label trial, 100 adults with SNHL and vertigo were randomized 1:1 to GAI plus conventional therapy or conventional therapy alone for 4 weeks. Co-primary outcomes were week-4 changes in pure-tone average (PTA) and Dizziness Handicap Inventory (DHI). The intention-to-treat analysis used multiple imputation for seven missing week-4 assessments; complete-case analysis was a sensitivity analysis. Results: The adjusted GAI-minus-control difference was −9.58 dB for PTA (95% CI, −12.55 to −6.61) and − 13.57 points for DHI (95% CI, −17.52 to −9.63); both remained significant after Holm adjustment. Complete-case estimates were similar (−9.72 dB and − 13.83 points). Exploratory Siegel recovery categories differed between groups ( P < 0.001), with any Siegel-defined improvement in 47/47 GAI participants and 32/46 controls with observed audiometry. Exploratory secondary and biomarker comparisons remained significant after false-discovery-rate adjustment. Adverse events occurred in 10/50 GAI and 9/50 control participants; no serious adverse events occurred. Conclusions: Allocation to the GAI treatment package was associated with greater week-4 improvement in hearing and self-reported dizziness handicap. Without a sham injection and with multiple background therapies, the gastrodin-specific effect cannot be isolated. Multicenter sham-controlled studies with objective follow-up vestibular testing are needed.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Otolaryngology Head and Neck Surgery, The First Hospital of Zhangjiakou, No. 6 Xinhua Street, Qiaoxi District, Zhangjiakou, Hebei, 075000, China",
    "Department of Neurosurgery, The First Hospital of Zhangjiakou, No. 6 Xinhua Street, Qiaoxi District, Zhangjiakou, Hebei, 075000, China; Corresponding author at: Department of Neurosurgery, The First Hospital of Zhangjiakou (West Campus), 2nd Floor, Building 4, West Campus of The First Hospital, Qiaoxi District, Zhangjiakou, Hebei, 075000, China.",
    "Department of Neurosurgery, The First Hospital of Zhangjiakou, No. 6 Xinhua Street, Qiaoxi District, Zhangjiakou, Hebei, 075000, China",
    "Department of Traditional Chinese Medicine, The First Hospital of Zhangjiakou, No. 6 Xinhua Street, Qiaoxi District, Zhangjiakou, Hebei, 075000, China"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 6,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Zhijie Wang"
    },
    {
      "affs": [
        0
      ],
      "name": "Dongchen Geng"
    },
    {
      "affs": [
        1
      ],
      "name": "Wu Yuan"
    },
    {
      "affs": [
        2
      ],
      "name": "Huijuan Zhang"
    },
    {
      "affs": [
        2
      ],
      "name": "Xiaoqin Zhao"
    },
    {
      "affs": [
        3
      ],
      "name": "Tao Yang"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/2kbpd63rb4ce5.bib",
  "cited_by": 0,
  "doi": "10.1016/j.amjoto.2026.104955",
  "fulltext_url": "http://www.sciencedirect.com/science/article/pii/S0196070926001717",
  "id": "2kbpd63rb4ce5",
  "issns": [
    "1532-818X",
    "0196-0709"
  ],
  "landing_url": "https://doi.org/10.1016/j.amjoto.2026.104955",
  "language": "en",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "lcc",
      "RF1-547"
    ],
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      "openalex",
      "2808|Vestibular and auditory disorders"
    ]
  ],
  "openalex": "W7214362565",
  "pdf_url": "https://www.sciencedirect.com/science/article/pii/S0196070926001717/pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-30",
  "publisher": "Elsevier",
  "ris": "https://research.draconitic.com/paper/2kbpd63rb4ce5.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:23Z",
      "native_id": "0df7b5cd25b24aa6af4791323cf95ecc",
      "source": "doaj",
      "url": "https://doi.org/10.1016/j.amjoto.2026.104955"
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  "subjects": [
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      "field": "medicine",
      "origin": "openalex:2808|Vestibular and auditory disorders",
      "subfield": "neurology"
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  "title": "Efficacy and safety of gastrodin acupoint injection as an adjunctive therapy for sensorineural hearing loss with vertigo: A randomized controlled trial",
  "title_text": "Efficacy and safety of gastrodin acupoint injection as an adjunctive therapy for sensorineural hearing loss with vertigo: A randomized controlled trial",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T13:43:39Z",
  "url": "https://research.draconitic.com/paper/2kbpd63rb4ce5",
  "venue": "American Journal of Otolaryngology",
  "versions": []
}