{
  "abstract": "The ability to form high-resolution episodic memories emerges relatively late in development, but the circuit mechanisms underlying this transition are unknown. CA1 receives entorhinal input through a direct monosynaptic pathway and an indirect trisynaptic pathway via the dentate gyrus and CA3. In mice, CA3[->]CA1 innervation matured later than MEC[->]CA1 innervation, with pronounced maturation between P20 and P24. Trisynaptic pathway maturation was necessary for high-resolution memory and was shaped by neuronal activity and early-life experience. Mechanistically, trisynaptic activity promoted perineuronal net assembly around downstream parvalbumin-expressing interneurons, facilitating their maturation and subsequent recruitment during learning to constrain CA1 encoding ensembles. Thus, activity-dependent maturation of trisynaptic circuitry provides a unified circuit and cellular account of a sensitive period for the emergence of episodic-like memory.",
  "abstract_shown": true,
  "affiliations": [
    "Hospital for Sick Children"
  ],
  "article_type": "New results",
  "arxiv": null,
  "author_total": 6,
  "authors": [
    {
      "name": "C. McKenzie"
    },
    {
      "name": "A. I. Ramsaran"
    },
    {
      "name": "M. Saderi"
    },
    {
      "name": "S. Haar"
    },
    {
      "name": "S. A. Josselyn"
    },
    {
      "affs": [
        0
      ],
      "name": "P. W. Frankland"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/2kdxgqvfxdz2v.bib",
  "cited_by": 0,
  "doi": "10.64898/2026.10.14.759228",
  "fulltext_url": "https://www.biorxiv.org/content/10.64898/2026.10.14.759228v1.full",
  "id": "2kdxgqvfxdz2v",
  "issns": [],
  "landing_url": "https://www.biorxiv.org/content/10.64898/2026.10.14.759228v1",
  "language": null,
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "biorxiv",
      "neuroscience"
    ],
    [
      "openalex",
      "2805|Memory and Neural Mechanisms"
    ]
  ],
  "openalex": "W7222664916",
  "pdf_url": "https://www.biorxiv.org/content/10.64898/2026.10.14.759228v1.full.pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-14",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/2kdxgqvfxdz2v.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:28:09Z",
      "native_id": "10.64898/2026.10.14.759228",
      "source": "biorxiv",
      "url": "https://www.biorxiv.org/content/10.64898/2026.10.14.759228v1"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "biorxiv:neuroscience",
      "subfield": "neuroscience"
    }
  ],
  "title": "Delayed maturation of hippocampal trisynaptic circuitry underlies the protracted development of episodic-like memory",
  "title_text": "Delayed maturation of hippocampal trisynaptic circuitry underlies the protracted development of episodic-like memory",
  "type": "preprint",
  "updated_at": "2026-10-30T12:28:09Z",
  "url": "https://research.draconitic.com/paper/2kdxgqvfxdz2v",
  "venue": "bioRxiv",
  "versions": []
}