{
  "abstract": "Background: Infertility is a major public health concern worldwide, with growing evidence implicating environmental exposures to heavy metals as potential contributors. This systematic review and meta-analysis aimed to evaluate the association between heavy metals in biological samples and infertility among men and women.\n\nMethods: Following PRISMA guidelines, a systematic search on PubMed, Scopus, and Web of Science was conducted. Observational studies reporting levels of arsenic, cadmium, chromium, mercury, nickel, and lead in infertile versus fertile individuals were included until December 2025. Data screening, data extraction and quality assessment was performed by two researchers independently. Heterogeneity between studies was assessed using Cochran’s Q test and the I² statistic. Meta-analysis was performed using fixed/random-effects model to pool standardized mean differences (SMD) and 95% confidence intervals (CI).\n\nResults: A total of 22 studies were included in the systematic review. In the qualitative synthesis, although the association of infertility with different heavy metals was statistically significant in the most of included studies, the findings were heterogeneous among studies. In the quantitative synthesis, seminal levels of cadmium (pooled SMD = 1.84, 95% CI: 0.15, 3.53), blood lead levels (SMD = 0.69, 95% CI: 0.06, 1.32), and blood mercury concentrations (SMD = 0.16, 95% CI: 0.02, 0.30) was significantly higher in infertile individuals compared with fertile counterparts. Other pooled associations between heavy metals and infertility were not statistically significant (p > 0.05).\n\nConclusion: The study findings support a significant association between heavy metals, particularly cadmium, lead and mercury with infertility. These findings underscore the importance of mitigating environmental and occupational exposure to heavy metals to protect reproductive health.\n\nSupplementary Information: The online version contains supplementary material available at https://doi.org/10.1186/s41043-026-01397-5.",
  "abstract_shown": true,
  "affiliations": [
    "Non-Communicable Diseases Research Center, Alborz University of Medical Sciences, Karaj, Iran",
    "Department of Nutrition, School of Health, Golestan University of Medical Sciences, Gorgan, Iran",
    "Non-Communicable Diseases Research Center, Endocrinology and Metabolism Population Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran",
    "Social Determinants of Health Research Center, Alborz University of Medical Sciences, Karaj, Iran"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 6,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Saba Goodarzi"
    },
    {
      "affs": [
        1
      ],
      "name": "Motahareh Hasani"
    },
    {
      "affs": [
        2
      ],
      "name": "Shirin Djalalinia"
    },
    {
      "affs": [
        3
      ],
      "name": "Razieh Lotfi"
    },
    {
      "affs": [
        0
      ],
      "name": "Armita Mahdavi-Gorabi"
    },
    {
      "affs": [
        0
      ],
      "name": "Mostafa Qorbani",
      "orcid": "0000-0001-9465-7588"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/2kj8mg2t45b2t.bib",
  "cited_by": 0,
  "doi": "10.1186/s41043-026-01397-5",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13711946/",
  "id": "2kj8mg2t45b2t",
  "issns": [
    "1606-0997",
    "2072-1315"
  ],
  "landing_url": "https://doi.org/10.1186/s41043-026-01397-5",
  "language": "en",
  "licence": "CC-BY-NC-ND-4.0",
  "licence_label": "CC BY-NC-ND 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Research"
    ],
    [
      "openalex",
      "2307|Heavy Metal Exposure and Toxicity"
    ]
  ],
  "openalex": "W7170168189",
  "pdf_url": null,
  "pmcid": "PMC13711946",
  "pmid": "42934836",
  "published": "2026-07-23",
  "publisher": "BMC",
  "ris": "https://research.draconitic.com/paper/2kj8mg2t45b2t.ris",
  "sources": [
    {
      "first_seen": "2026-10-31T12:22:38Z",
      "native_id": "PMC13711946",
      "source": "pmc",
      "url": "https://doi.org/10.1186/s41043-026-01397-5"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2307|Heavy Metal Exposure and Toxicity",
      "subfield": "pharmacology-toxicology"
    }
  ],
  "title": "Heavy metals exposure and infertility: a systematic review and meta-analysis of observational studies",
  "title_text": "Heavy metals exposure and infertility: a systematic review and meta-analysis of observational studies",
  "type": "peer-reviewed",
  "updated_at": "2026-10-31T12:22:38Z",
  "url": "https://research.draconitic.com/paper/2kj8mg2t45b2t",
  "venue": "Journal of Health, Population, and Nutrition",
  "versions": []
}