{
  "abstract": "Background\n\nThe aim of this systematic review is to assess the evidence of the effect of cryotherapy on the development of chemotherapy-induced peripheral neuropathy (CIPN) in patients with breast cancer in neoadjuvant or adjuvant chemotherapy.Method\n\nStudies investigating the effect of cryotherapy as a preventive intervention for CIPN in patients with breast cancer treated with taxanes were eligible for inclusion. Non-English and non-German publications and studies inaccessible due to paywall restrictions were excluded. A systematic literature search was conducted in PubMed and Embase on 29 May 2026. The certainty of evidence was assessed using the GRADE method.Results\n\nTwenty-two studies involving 3369 participants were included.The included evidence suggests that cryotherapy may reduce the incidence and severity of CIPN in patients with breast cancer receiving taxanes. However, the certainty of the evidence was low overall because of study limitations such as small sample sizes, non-randomised study designs and heterogeneity.Conclusion\n\nThe preventive effect of cryotherapy on the development of CIPN in patients with breast cancer receiving taxanes cannot be ruled out. The overall quality of evidence in the included studies is low. Therefore, it is not possible to conclude with certainty if cryotherapy can prevent the development of CIPN. Larger randomised controlled trials using objective measures such as nerve conduction studies are needed.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Oncology, Aarhus University Hospital, Aarhus, Denmark.",
    "Department of Orthopaedic Surgery, Randers Regional Hospital, Randers, Denmark.",
    "Department of Oncology and Palliative Medicine, Nordsjaellands Hospital, Hillerød, Denmark.",
    "Department of Neurophysiology, Aarhus University Hospital, Aarhus, Denmark.",
    "Department of Clinical Medicine, Aarhus University, Aarhus, Denmark."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 4,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Rikke Elgaard Gravesen",
      "orcid": "0009-0001-2574-516X"
    },
    {
      "affs": [
        2
      ],
      "name": "Maria Elisabeth Lendorf"
    },
    {
      "affs": [
        3,
        4
      ],
      "name": "Hatice Tankisi"
    },
    {
      "affs": [
        0,
        4
      ],
      "name": "Anders Bonde Jensen"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/2kkcnzwcs89bq.bib",
  "cited_by": 0,
  "doi": "10.1136/bmjno-2026-001602",
  "fulltext_url": "https://europepmc.org/articles/PMC13691834",
  "id": "2kkcnzwcs89bq",
  "issns": [
    "2632-6140"
  ],
  "landing_url": "https://europepmc.org/article/MED/42921167",
  "language": "eng",
  "licence": "CC-BY-NC",
  "licence_label": "CC BY-NC",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2730|Cancer Treatment and Pharmacology"
    ]
  ],
  "openalex": "W7222263249",
  "pdf_url": "https://europepmc.org/articles/PMC13691834?pdf=render",
  "pmcid": "PMC13691834",
  "pmid": "42921167",
  "published": "2026-10-15",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/2kkcnzwcs89bq.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:20:33Z",
      "native_id": "MED:42921167",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42921167"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2730|Cancer Treatment and Pharmacology",
      "subfield": "oncology"
    }
  ],
  "title": "Effect of cryotherapy on chemotherapy-induced peripheral neuropathy in patients with breast cancer treated with taxanes: a systematic review using the GRADE system.",
  "title_text": "Effect of cryotherapy on chemotherapy-induced peripheral neuropathy in patients with breast cancer treated with taxanes: a systematic review using the GRADE system.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:20:33Z",
  "url": "https://research.draconitic.com/paper/2kkcnzwcs89bq",
  "venue": "BMJ neurology open",
  "versions": []
}