{
  "abstract": "Obesity-related adipose tissue (AT) dysfunction is closely associated with the development and progression of metabolic dysfunction-associated steatotic liver disease (MASLD), the most prevalent chronic liver disease. Emerging evidence highlights that the AT-liver crosstalk is mediated by AT-derived extracellular vesicles (EVs) that exacerbate the progression of MASLD during obesity. During obesity development, AT undergoes pathological remodeling characterized by hypertrophic adipocytes, pro-inflammatory macrophages, dysfunctional adipose-derived stem cells (ADSCs), and increased cellular heterogeneity, which collectively alter the composition and function of secreted EVs. AT-derived EVs enter the circulation and transport bioactive cargo, including microRNAs (miRNAs), mtDNA, proteins and lipids to the liver, where they can modulate hepatocellular metabolism, liver inflammation and fibrogenesis. This review outlines the current state of knowledge on AT-derived EVs during MASLD, emphasizing the dynamic changes in AT under metabolic stress as well as the interactions between AT-derived EVs and the liver. We further explore the potential of EVs and their associated molecules as noninvasive biomarkers and potential therapeutic targets and underscore that understanding AT-liver communication via EVs offers perspectives for precision medicine in MASLD.",
  "abstract_shown": true,
  "affiliations": [
    "Department of In Vitro Toxicology and Dermato-Cosmetology (IVTD), Faculty of Medicine and Pharmacy, Vrije Universiteit Brussel (VUB), Brussels 1090, Belgium",
    "Translational Oncology Research Center (TORC), Hematology and Immunology (HEIM), Vrije Universiteit Brussel (VUB), Brussels 1090, Belgium",
    "State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica (SIMM), Chinese Academy of Sciences, Shanghai 201203, China",
    "Hepatology Research Unit, Department of Internal Medicine and Pediatrics, Ghent University, Ghent 9000, Belgium"
  ],
  "article_type": "review article",
  "arxiv": null,
  "author_total": 11,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Qiuyang Chen"
    },
    {
      "affs": [
        0
      ],
      "name": "Taisiia Shevchenko"
    },
    {
      "affs": [
        1
      ],
      "name": "Dewen Zhan"
    },
    {
      "affs": [
        2
      ],
      "name": "Ningning Ma"
    },
    {
      "affs": [
        3
      ],
      "name": "Sander Lefere"
    },
    {
      "affs": [
        0
      ],
      "name": "Joost Boeckmans"
    },
    {
      "affs": [
        0
      ],
      "name": "Joery De Kock"
    },
    {
      "affs": [
        0
      ],
      "name": "Freddy Van Goethem"
    },
    {
      "affs": [
        2
      ],
      "name": "Yong He"
    },
    {
      "affs": [
        0
      ],
      "name": "Tamara Vanhaecke"
    },
    {
      "affs": [
        0
      ],
      "name": "Robim M. Rodrigues"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/2krahtw2nbbd0.bib",
  "cited_by": 0,
  "doi": "10.1016/j.apsb.2026.08.025",
  "fulltext_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13729536/?tool=EBI",
  "id": "2krahtw2nbbd0",
  "issns": [
    "2211-3835",
    "2211-3843"
  ],
  "landing_url": "https://europepmc.org/article/PMC/PMC13729536",
  "language": "eng",
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Review"
    ],
    [
      "openalex",
      "1312|Extracellular vesicles in disease"
    ]
  ],
  "openalex": "W7206154911",
  "pdf_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13729536/pdf/?tool=EBI",
  "pmcid": "PMC13729536",
  "pmid": "42979082",
  "published": "2026-09-02",
  "publisher": "Elsevier",
  "ris": "https://research.draconitic.com/paper/2krahtw2nbbd0.ris",
  "sources": [
    {
      "first_seen": "2026-11-04T15:20:47Z",
      "native_id": "PMC:PMC13729536",
      "source": "europepmc",
      "url": "https://europepmc.org/article/PMC/PMC13729536"
    },
    {
      "first_seen": "2026-11-07T12:22:16Z",
      "native_id": "PMC13729536",
      "source": "pmc",
      "url": "https://doi.org/10.1016/j.apsb.2026.08.025"
    }
  ],
  "subjects": [
    {
      "field": "biochemistry",
      "origin": "openalex:1312|Extracellular vesicles in disease",
      "subfield": "molecular-biology"
    }
  ],
  "title": "Molecular smugglers in obesity-driven MASLD: Snitching on adipose-derived extracellular vesicles",
  "title_text": "Molecular smugglers in obesity-driven MASLD: Snitching on adipose-derived extracellular vesicles",
  "type": "peer-reviewed",
  "updated_at": "2026-11-07T12:22:16Z",
  "url": "https://research.draconitic.com/paper/2krahtw2nbbd0",
  "venue": "Acta pharmaceutica Sinica. B",
  "versions": []
}