{
  "abstract": "Zearalenone (ZEN), a potent endocrine-disrupting mycotoxin produced by Fusarium fungi, frequently contaminates cereal-based foods worldwide, necessitating reliable analytical methods for food safety and regulatory compliance. Herein, we report an innovative dual-readout sensing strategy for both fluorometric and colorimetric quantification of ZEN, based on a unified catalytic nanoplatform of iron and nitrogen co-doped carbon dots decorated with γ-cyclodextrin (γ-CD/Fe, N-CDs). The enlarged macrocyclic cavity of γ-CD selectively accommodates the bulky 14-membered resorcylic acid lactone ring of ZEN via host-guest binding, simultaneously triggering two distinct signaling pathways: static quenching of the intrinsic carbon dot fluorescence through ground-state complex formation, and inhibition of TMB oxidation as the captured ZEN scavenges hydroxyl radicals generated by the proximal iron catalytic centers, reducing colorimetric signal intensity in a dose-dependent manner. The fluorescence channel exhibited linearity over 0.5-80.0 ng mL⁻¹ with an LOD of 0.21 ng mL⁻¹, while the colorimetric channel was linear over 5.0-55.0 ng mL⁻¹ with an LOD of 1.6 ng mL⁻¹. Applied to commercial wheat flour samples, the method yielded recoveries of 95.8-102.4% with RSDs below 4%, showing no significant deviation from conventional reference techniques. This bifunctional nanodevice offers a robust, mutually corroborating dual-channel platform for high-throughput ZEN surveillance in grain commodities.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Najran University Najran Kingdom of Saudi Arabia.",
    "Health Research Center, Najran University Najran Kingdom of Saudi Arabia.",
    "Basic Research Laboratory, Department of Food Science and Technology, GreenTech-based Food Safety Research Group, BK21 Four, Chung-Ang University Anseong 17546 Republic of Korea.",
    "Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy, Assiut University Assiut Egypt Almontaser_bellah@aun.edu.eg.",
    "Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Tabuk Tabuk 71491 Saudi Arabia.",
    "Assiut National University New Assiut City Assiut 11511 Egypt."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 7,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Ashraf M Mahmoud"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Ali O Alqarni"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Rayed Ali A Alqahtani"
    },
    {
      "affs": [
        2
      ],
      "name": "Jong Pil Park",
      "orcid": "0000-0002-4119-1574"
    },
    {
      "affs": [
        3
      ],
      "name": "Mohamed M El-Wekil",
      "orcid": "0000-0002-1097-1148"
    },
    {
      "affs": [
        4
      ],
      "name": "Ramadan Ali"
    },
    {
      "affs": [
        3,
        5
      ],
      "name": "Al-Montaser Bellah H Ali",
      "orcid": "0009-0003-2631-6038"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/2mfbpyffy996s.bib",
  "cited_by": 0,
  "doi": "10.1039/d6ra07703j",
  "fulltext_url": "https://europepmc.org/articles/PMC13679709",
  "id": "2mfbpyffy996s",
  "issns": [
    "2046-2069"
  ],
  "landing_url": "https://europepmc.org/article/MED/42899244",
  "language": "eng",
  "licence": "CC-BY-NC",
  "licence_label": "CC BY-NC",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2505|Advanced Nanomaterials in Catalysis"
    ]
  ],
  "openalex": "W7222936702",
  "pdf_url": "https://europepmc.org/articles/PMC13679709?pdf=render",
  "pmcid": "PMC13679709",
  "pmid": "42899244",
  "published": "2026-10-19",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/2mfbpyffy996s.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:19:33Z",
      "native_id": "MED:42899244",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42899244"
    }
  ],
  "subjects": [
    {
      "field": "chemistry",
      "origin": "openalex:2505|Advanced Nanomaterials in Catalysis",
      "subfield": "materials-polymers"
    }
  ],
  "title": "A dual-mode γ-CD/Fe,N-CD nanozyme enabled by host-guest interactions for the dual-mode fluorometric and colorimetric monitoring of zearalenone in wheat flour.",
  "title_text": "A dual-mode γ-CD/Fe,N-CD nanozyme enabled by host-guest interactions for the dual-mode fluorometric and colorimetric monitoring of zearalenone in wheat flour.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:19:33Z",
  "url": "https://research.draconitic.com/paper/2mfbpyffy996s",
  "venue": "RSC advances",
  "versions": []
}