{
  "abstract": "Introduction\n\nNovel tools for absolute quantification of established and emerging fluid neuro-biomarkers are required to advance diagnostic studies and improve biological insights.Methods\n\nWe conducted an extensive analytical and clinical validation of the Olink™ Target 48 Neurodegeneration panel (T48 Neuropanel) in 352 paired cerebrospinal fluid (CSF) and plasma samples from cognitively unimpaired controls (CU), Alzheimer's dementia (AD), frontotemporal dementia (FTD), and dementia with Lewy bodies (DLB), n = 44 per group. Comparisons with benchmark assays were performed.Results\n\nGood detectability (CSF: 31 out of 42 assays; plasma: 38 out of 42 assays) and technical performance was observed. Benchmark assays showed good correlations, supporting transformation formula's. Next to emerging biomarkers (MMP10, ITGB2), discriminative performance was excellent in AD: CSF pTau217: area under the curve (AUC) = 1; FTD: plasma neurofilament light chain (NfL): AUC = 0.952; and DLB: CSF dopa decarboxylase (DDC): AUC = 0.901.Discussion\n\nThis analytical and clinical validation of the T48 Neuropanel highlights initial cutoffs and emerging biomarkers to aid clinical studies for the diagnosis, prognosis, and monitoring of neurodegenerative diseases.",
  "abstract_shown": true,
  "affiliations": [
    "Neurochemistry Laboratory, Department of Laboratory Medicine, Amsterdam Neuroscience, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, North Holland, The Netherlands.",
    "Barcelonaßeta Brain Research Center, Pasqual Maragall Foundation, Barcelona, Catalonia, Spain.",
    "Hospital del Mar Research Institute, Barcelona, Catalonia, Spain.",
    "Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, VU University Medical Center, Amsterdam UMC, Amsterdam, North Holland, The Netherlands."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 9,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Yanaika S Hok-A-Hin"
    },
    {
      "affs": [
        0
      ],
      "name": "Lisa Vermunt"
    },
    {
      "affs": [
        0
      ],
      "name": "Natascha de Jong"
    },
    {
      "affs": [
        1,
        2
      ],
      "name": "Marta Del Campo Milan"
    },
    {
      "affs": [
        3
      ],
      "name": "Everard Vijverberg"
    },
    {
      "affs": [
        3
      ],
      "name": "Afina W Lemstra"
    },
    {
      "affs": [
        3
      ],
      "name": "Yolande Pijnenburg"
    },
    {
      "affs": [
        3
      ],
      "name": "Argonde C van Harten"
    },
    {
      "affs": [
        0
      ],
      "name": "Charlotte E Teunissen"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/2mst20zrnbyaf.bib",
  "cited_by": 0,
  "doi": "10.1002/alz.71866",
  "fulltext_url": "https://europepmc.org/articles/PMC13715063",
  "id": "2mst20zrnbyaf",
  "issns": [
    "1552-5260",
    "1552-5279"
  ],
  "landing_url": "https://europepmc.org/article/MED/42949229",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Research Article"
    ],
    [
      "openalex",
      "2738|Dementia and Cognitive Impairment Research"
    ]
  ],
  "openalex": "W7164884794",
  "pdf_url": "https://europepmc.org/articles/PMC13715063?pdf=render",
  "pmcid": "PMC13715063",
  "pmid": "42949229",
  "published": "2026-10-01",
  "publisher": "Wiley",
  "ris": "https://research.draconitic.com/paper/2mst20zrnbyaf.ris",
  "sources": [
    {
      "first_seen": "2026-10-31T00:20:35Z",
      "native_id": "MED:42949229",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42949229"
    },
    {
      "first_seen": "2026-11-01T12:22:26Z",
      "native_id": "PMC13715063",
      "source": "pmc",
      "url": "https://doi.org/10.1002/alz.71866"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2738|Dementia and Cognitive Impairment Research",
      "subfield": "psychiatry"
    }
  ],
  "title": "The Target48 Neurodegeneration panel: A novel tool for profiling protein signatures in neurodegenerative disorders.",
  "title_text": "The Target48 Neurodegeneration panel: A novel tool for profiling protein signatures in neurodegenerative disorders.",
  "type": "peer-reviewed",
  "updated_at": "2026-11-01T12:22:26Z",
  "url": "https://research.draconitic.com/paper/2mst20zrnbyaf",
  "venue": "Alzheimer's & dementia : the journal of the Alzheimer's Association",
  "versions": []
}