{
  "abstract": "Objective: We evaluated whether dysglycaemia is an independent factor associated with bone mineral density (BMD) gain during romosozumab treatment.\n\nMethods: We included all patients who initiated and received 12 doses of romosozumab in two Osteoporosis Centres from January 2019 to March 2025 and had dual-energy X-ray absorptiometry performed at baseline and upon completion of romosozumab. The cohort was divided into three groups. Diabetes was defined by physician diagnosis, glycated haemoglobin (HbA1c) ≥ 6.5%, or anti-diabetic medication use. Among those without known diabetes, HbA1c 5.7%–6.4% defined prediabetes and HbA1c ≤ 5.6% defined normoglycaemia. Percentage of BMD (%BMD) gain while on romosozumab was calculated. Multivariable linear regression analysis was used to identify independent factors associated with %BMD gain.\n\nResults: A total of 170 patients were included (age 71.6 ± 9.6 years; 167 women, 3 men; body mass index (BMI) 21.0 ± 3.6 kg/m ² ): 59.4% had normoglycaemia, 25.9% prediabetes, and 14.7% diabetes (all type 2). Of these, 64.1% had prior antiresorptive exposure. Baseline mean BMD T-scores (95% CI) were −3.0 (−3.2, −2.9) (lumbar spine, LS), −2.9 (−3.1, −2.8) (femoral neck, FN), and −2.6 (−2.7, −2.4) (total hip, TH). In total, 69.4% had prior fractures. Overall %BMD gain was 12.1% (95% CI 10.5%–13.7%) (LS), 3.6% (95% CI 2.4%–4.7%) (FN), and 3.4% (95% CI 2.5%–4.3%) (TH). Across the three glycaemic categories, %BMD gain did not differ (LS: p = 0.821; FN: p = 0.776; TH: p = 0.985). HbA1c did not correlate with %BMD gain. Baseline BMD T-score and prior antiresorptive treatment were the independent factors inversely associated with %BMD gain.\n\nConclusion: This real-world study showed BMD gains of 12% at the LS and 3.5% at the hip with 12 doses of romosozumab. No statistically significant association was identified between baseline glycaemic category and one-year BMD change during romosozumab treatment. However, the relatively small diabetes subgroup limits the precision of this estimate.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Medicine, School of Clinical Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong",
    "Department of Medicine, Queen Mary Hospital",
    "Department of Non-communicable Disease Epidemiology, Faculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine",
    "Department of Surgery, School of Clinical Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong",
    "Department of Medicine, Alice Ho Miu Ling Nethersole Hospital",
    "Department of Medicine, Tung Wah Hospital",
    "Osteoporosis and Bone Metabolism Unit, Department of Endocrinology, Singapore General Hospital",
    "Duke-NUS Medical School",
    "Asia Pacific Consortium on Osteoporosis (APCO)",
    "Division of Endocinology, Diabetes, and Bone Diseases, Department of Medicine III, Technische Universität Dresden Medical Center",
    "Center for Healthy Aging, Technische Universität Dresden Medical Center"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 15,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Kimberly H. Tsoi"
    },
    {
      "affs": [
        2
      ],
      "name": "Xi Xiong"
    },
    {
      "affs": [
        3
      ],
      "name": "Xiaodong Liu"
    },
    {
      "affs": [
        4
      ],
      "name": "Chun-Ho Wong"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Carol H. Y. Fong"
    },
    {
      "affs": [
        3
      ],
      "name": "Matrix M. H. Fung"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Eunice K. H. Leung"
    },
    {
      "affs": [
        0,
        5
      ],
      "name": "Alan C. H. Lee"
    },
    {
      "affs": [
        0,
        5
      ],
      "name": "Tai-Pang Ip"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Kathryn C. B. Tan"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Chi-Ho Lee"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Yu-Cho Woo"
    },
    {
      "affs": [
        6,
        7,
        8
      ],
      "name": "Manju Chandran"
    },
    {
      "affs": [
        9,
        10
      ],
      "name": "Elena Tsourdi"
    },
    {
      "affs": [
        0,
        1,
        8
      ],
      "name": "David T. W. Lui"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/2n4eqwh86xmf1.bib",
  "cited_by": 0,
  "doi": "10.3389/fendo.2026.1941784",
  "fulltext_url": "https://europepmc.org/articles/PMC13713262",
  "id": "2n4eqwh86xmf1",
  "issns": [
    "1664-2392"
  ],
  "landing_url": "https://www.frontiersin.org/articles/10.3389/fendo.2026.1941784/full",
  "language": "eng",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Original Research"
    ],
    [
      "openalex",
      "2732|Bone health and osteoporosis research"
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  "openalex": "W7221787596",
  "pdf_url": "https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2026.1941784/pdf",
  "pmcid": "PMC13713262",
  "pmid": "42952517",
  "published": "2026-10-14",
  "publisher": "Frontiers Media SA",
  "ris": "https://research.draconitic.com/paper/2n4eqwh86xmf1.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:20:20Z",
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      "url": "https://www.frontiersin.org/articles/10.3389/fendo.2026.1941784/full"
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  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2732|Bone health and osteoporosis research",
      "subfield": "surgery"
    }
  ],
  "title": "Association of baseline glycaemic status with BMD change after 12 doses of romosozumab: a retrospective cohort study of 170 patients",
  "title_text": "Association of baseline glycaemic status with BMD change after 12 doses of romosozumab: a retrospective cohort study of 170 patients",
  "type": "peer-reviewed",
  "updated_at": "2026-11-01T12:20:57Z",
  "url": "https://research.draconitic.com/paper/2n4eqwh86xmf1",
  "venue": "Frontiers in Endocrinology",
  "versions": []
}