{
  "abstract": "High levels of IL-18 have been causally implicated in IBD risk and may represent a unique mechanism driving IBD yet to be therapeutically targeted. To identify individuals predisposed to increased levels of IL-18, we implemented a polygenic approach to predict IL-18 plasma protein levels. Using a dataset with over 50,000 individuals with both genetic and plasma protein levels from Olink, we developed a 27 SNP polygenic score that predicts IL-18 levels and IBD risk. Further, we identified a threshold to classify patients as IL-18 High using a data-driven approach that optimized prediction of both IL-18 and IBD risk. We show that [~]30% of the overall IBD patient population is IL-18 High, meaning a genetic predisposition towards higher protein levels. The IL-18 PGS and corresponding threshold have the potential to identify IBD patients with IL-18-driven IBD that may respond more effectively to a therapy targeting this mechanism.",
  "abstract_shown": true,
  "affiliations": [
    "Bristol Myers Squibb"
  ],
  "article_type": "PUBLISHAHEADOFPRINT",
  "arxiv": null,
  "author_total": 6,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "M. C. Turchin"
    },
    {
      "name": "N. Raghupathy"
    },
    {
      "name": "C. L. Carty"
    },
    {
      "name": "M. Morris"
    },
    {
      "name": "J. C. Maranville"
    },
    {
      "name": "E. R. Holzinger"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/2n6gmda7b003s.bib",
  "cited_by": 0,
  "doi": "10.64898/2026.05.18.26353508",
  "fulltext_url": "https://www.medrxiv.org/content/10.64898/2026.05.18.26353508v2.full",
  "id": "2n6gmda7b003s",
  "issns": [],
  "landing_url": "https://www.medrxiv.org/content/10.64898/2026.05.18.26353508v2",
  "language": null,
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "medrxiv",
      "genetic and genomic medicine"
    ],
    [
      "openalex",
      "1311|Inflammatory Bowel Disease"
    ]
  ],
  "openalex": "W7162036701",
  "pdf_url": "https://www.medrxiv.org/content/10.64898/2026.05.18.26353508v2.full.pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-05-18",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/2n6gmda7b003s.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:21:38Z",
      "native_id": "10.64898/2026.05.18.26353508",
      "source": "medrxiv",
      "url": "https://www.medrxiv.org/content/10.64898/2026.05.18.26353508v2"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "medrxiv:genetic and genomic medicine",
      "subfield": "human-genetics"
    }
  ],
  "title": "A proteomic polygenic score to identify IL-18 driven inflammatory bowel disease",
  "title_text": "A proteomic polygenic score to identify IL-18 driven inflammatory bowel disease",
  "type": "preprint",
  "updated_at": "2026-10-30T12:21:38Z",
  "url": "https://research.draconitic.com/paper/2n6gmda7b003s",
  "venue": "medRxiv",
  "versions": []
}