{
  "abstract": "The Advanced Breast Cancer (ABC) 8th international consensus conference took place on 6-8 November 2025, in Lisbon, and updated the previous ABC international consensus guidelines that are described in this manuscript. These guidelines reflect the work of a large and global consensus panel, comprising healthcare professionals and patients, and provide recommendations on how to best manage patients with advanced breast cancer (inoperable locally advanced or metastatic), of all breast cancer subtypes. The guidelines are based on the best available evidence or on expert opinion when a higher level of evidence is lacking and aim to cover the needs of the person living with ABC, including but also beyond the main therapeutic recommendations. Each guideline is accompanied by the level of evidence (LoE), the grade of recommendation (GoR), and the percentage of consensus reached at the consensus session. Updated diagnostic and treatment algorithms are also provided. These guidelines are endorsed by several international oncology organizations (AGO, AORTIC, ECO, EONS, ESO, ESTRO, EUSOMA, GECO Perú, SUMA, MASCC, French Breast Cancer Guidelines and AMAAC) and have official representation from ASCO, NCCN and ABC-NZ.\n\nInequalities in access to high-quality care have increased in the last decade, both between and within countries, and are a major concern. The ABC guidelines provide guidance on the best available management options for patients living with ABC globally, assuming availability of the recommended therapies. Their adaptation is often needed in resource-constrained settings, and the grading of each recommendation may help in prioritizing access to available options.",
  "abstract_shown": true,
  "affiliations": [
    "ABC Global Alliance, Lisbon, Portugal; Centre Antoine Lacassagne, Nice, France. Electronic address: fcardoso@abcglobalalliance.org.",
    "Gustave Roussy, Villejuif, France.",
    "Mamma Mia, Kronberg, Germany.",
    "Georgetown University Lombardi Comprehensive Cancer Center and MedStar Health, Washington, USA.",
    "Hadassah University Hospital - Sharett Institute of Oncology and Faculty of Medicine, Hebrew University, Jerusalem, Israel.",
    "Centre Jean Perrin, Université Clermont Auvergne, INSERM, U1240 Imagerie Moléculaire et Stratégies Théranostiques, Clermont Ferrand, France.",
    "Dana-Farber Cancer Institute, Boston, USA.",
    "Peter MacCallum Cancer Centre Melbourne, Australia.",
    "Te Whatu Ora-Health New Zealand, Te Manawa Taki, Waikato District, Hamilton, New Zealand.",
    "University Medical Center Utrecht, Netherlands.",
    "Netherlands Cancer Institute, The Netherlands and AURORA Steering Committee, Amsterdam, Netherlands.",
    "Instituto Valenciano de Oncologia, Valencia, Spain; AURORA Steering Committee, Valencia, Spain.",
    "IMO Clinique de Genolier, Institut Multidisciplinare d'Oncologie, Genolier, Switzerland.",
    "Fadia Survive & Thrive, Salmiya, Kuwait.",
    "Tata Memorial Hospital, Mumbai, India.",
    "Centro de Pesquisa em Oncologia, Hospital São Lucas, PUCRS and Latin American Cooperative Oncology Group (LACOG), Porto Alegre, Brazil.",
    "Department of Oncology, Hospital of Prato, Azienda USL Toscana Centro, Prato, Italy.",
    "The Pam McLean Centre, Royal North Shore Hospital, St. Leonards, Australia.",
    "Instituto de Oncología \"Ángel H. Roffo\", Buenos Aires, Argentina.",
    "UNC Lineberger Comprehensive Cancer Center, Chapel Hill, USA.",
    "The University of Texas MD Anderson Cancer Center, Houston, USA.",
    "International Breast Cancer Center (IBCC), Madrid and Barcelona, Spain.",
    "National Cancer Center Singapore, Singapore.",
    "Trinity Centre for Healthcare Practice and Innovation, School of Nursing and Midwifery, Trinity College Dublin, Ireland.",
    "NK Basile Cancer Institute American University of Beirut Medical Center, Beirut, Lebanon.",
    "Breast and Gynaecological International Cancer Society, Cairo, Egypt.",
    "Breast Center, Genolier Cancer Center, Genolier, Switzerland.",
    "Sussex Health Outcomes Research & Education in Cancer, Brighton & Sussex Medical School, University of Sussex, Brighton, UK.",
    "CTIC Cancer Treatment and Research Center, Bogotá, Colombia.",
    "British Columbia Cancer Agency, Vancouver, Canada.",
    "Macquarie University, Sydney, Australia.",
    "Cancer Est APHP Tenon, University Paris VI, Paris, France.",
    "Robert H. Lurie Comprehensive Cancer Center and Northwestern University Feinberg School of Medicine, Chicago, USA.",
    "Breast Centre, University of Munich, Munich, Germany.",
    "Fudan University Shanghai Cancer Center, Shanghai, China.",
    "Sheba Medical Center, Ramat Gan and Gray Faculty of Medical & Health Sciences, Tel Aviv University, Israel.",
    "National Cancer Society Malaysia (NCSM), Kuala Lumpur, Malaysia.",
    "NHMRC Clinical Trials Centre, Sydney Medical School, Sydney, Australia.",
    "Asan Medical Centre, University of Ulsan College of Medicine, Seoul, Republic of Korea.",
    "Muhimbili National Hospital, Dar es Salaam, Tanzania."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 53,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Fatima Cardoso",
      "orcid": "0000-0002-6692-2249"
    },
    {
      "affs": [
        1
      ],
      "name": "Joana Mourato Ribeiro"
    },
    {
      "affs": [
        2
      ],
      "name": "Eva Schumacher-Wulf"
    },
    {
      "affs": [
        3
      ],
      "name": "Sandra M Swain"
    },
    {
      "affs": [
        4
      ],
      "name": "Shani Paluch-Shimon"
    },
    {
      "affs": [
        5
      ],
      "name": "Frederique Penault-Llorca",
      "orcid": "0000-0002-4279-5492"
    },
    {
      "affs": [
        6
      ],
      "name": "Nancy U Lin"
    },
    {
      "affs": [
        7
      ],
      "name": "Prudence A Francis"
    },
    {
      "affs": [
        8
      ],
      "name": "Marion Kuper-Hommel"
    },
    {
      "affs": [
        9
      ],
      "name": "Anne May"
    },
    {
      "affs": [
        10
      ],
      "name": "Florentine Hilbers"
    },
    {
      "affs": [
        11
      ],
      "name": "Angel Guerrero"
    },
    {
      "affs": [
        12
      ],
      "name": "Matti S Aapro"
    },
    {
      "affs": [
        13
      ],
      "name": "Rania Azmi"
    },
    {
      "affs": [
        14
      ],
      "name": "Jyoti Bajpai"
    },
    {
      "affs": [
        15
      ],
      "name": "Carlos Barrios"
    },
    {
      "affs": [
        16
      ],
      "name": "Laura Biganzoli"
    },
    {
      "affs": [
        17
      ],
      "name": "Fran Boyle"
    },
    {
      "affs": [
        18
      ],
      "name": "Valeria Caceres"
    },
    {
      "affs": [
        19
      ],
      "name": "Lisa A Carey"
    },
    {
      "affs": [
        20
      ],
      "name": "Mariana Chavez-MacGregor"
    },
    {
      "affs": [
        21
      ],
      "name": "Javier Cortés"
    },
    {
      "affs": [
        22
      ],
      "name": "Rebecca Dent"
    },
    {
      "affs": [
        23
      ],
      "name": "Amanda Drury"
    },
    {
      "affs": [
        24
      ],
      "name": "Nagi S El Saghir"
    },
    {
      "affs": [
        25
      ],
      "name": "Hesham Elghazaly"
    },
    {
      "affs": [
        26
      ],
      "name": "Alexandru Eniu"
    },
    {
      "affs": [
        27
      ],
      "name": "Lesley Fallowfield",
      "orcid": "0000-0003-0577-4518"
    },
    {
      "affs": [
        28
      ],
      "name": "Sandra Ximena Franco Millan"
    },
    {
      "affs": [
        29
      ],
      "name": "Karen Gelmon"
    },
    {
      "affs": [
        30
      ],
      "name": "Jenny Gilchrist"
    },
    {
      "affs": [
        31
      ],
      "name": "Joseph Gligorov"
    },
    {
      "affs": [
        32
      ],
      "name": "William J Gradishar"
    },
    {
      "affs": [
        33
      ],
      "name": "Nadia Harbeck"
    },
    {
      "affs": [
        34
      ],
      "name": "Xichun Hu"
    },
    {
      "affs": [
        35
      ],
      "name": "Orit Kaidar-Person"
    },
    {
      "affs": [
        36
      ],
      "name": "Ranjit Kaur"
    },
    {
      "affs": [
        37
      ],
      "name": "Belinda Kiely"
    },
    {
      "affs": [
        38
      ],
      "name": "Sung-Bae Kim"
    },
    {
      "affs": [
        39
      ],
      "name": "Sarah Kutika Nyagabona"
    },
    {
      "name": "Maryam Lustberg"
    },
    {
      "name": "Volkmar Mueller"
    },
    {
      "name": "Miriam Mutebi"
    },
    {
      "name": "Silvia Neciosup"
    },
    {
      "name": "Shinji Ohno"
    },
    {
      "affs": [
        1
      ],
      "name": "Barbara Pistilli"
    },
    {
      "name": "Hope S Rugo"
    },
    {
      "name": "Tanja Spanic"
    },
    {
      "name": "Janice Tsang"
    },
    {
      "name": "Peter Vuylsteke"
    },
    {
      "name": "Binghe Xu"
    },
    {
      "name": "Larry Norton"
    },
    {
      "name": "Eric P Winer"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/2nqzmk3bacg1n.bib",
  "cited_by": 0,
  "doi": "10.1016/j.breast.2026.104921",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13697336/",
  "id": "2nqzmk3bacg1n",
  "issns": [
    "0960-9776",
    "1532-3080"
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  "landing_url": "https://doi.org/10.1016/j.breast.2026.104921",
  "language": "en",
  "licence": "CC-BY-NC-ND-4.0",
  "licence_label": "CC BY-NC-ND 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Original Article"
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      "1306|Breast Cancer Treatment Studies"
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  "openalex": "W7213464691",
  "pdf_url": "https://europepmc.org/articles/PMC13697336?pdf=render",
  "pmcid": "PMC13697336",
  "pmid": "42893682",
  "published": "2026-09-17",
  "publisher": "Elsevier",
  "ris": "https://research.draconitic.com/paper/2nqzmk3bacg1n.ris",
  "sources": [
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  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:1306|Breast Cancer Treatment Studies",
      "subfield": "oncology"
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  "title": "8th International consensus guidelines for the management of advanced breast cancer (ABC8 guidelines)",
  "title_text": "8th International consensus guidelines for the management of advanced breast cancer (ABC8 guidelines)",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:34:23Z",
  "url": "https://research.draconitic.com/paper/2nqzmk3bacg1n",
  "venue": "The Breast : Official Journal of the European Society of Mastology",
  "versions": []
}