{
  "abstract": "M and below) represents additional challenges. In this paper, we first describe a fast and reliable method to measure aqueous solubility of drug-like molecules in a 96-well plate format using only conventional laboratory equipment and a UV absorbance plate reader. The method was validated against the gold-standard saturation shake-flask on a set of 31 drug molecules and represents a practical improvement over already described high-throughput solubility determination methods. We then use this method to explore the solubility of six poorly soluble molecules in water-organic solvent mixtures. We discuss the relationship between solvent fraction and logarithmic solubility (logS), conditions to make this relationship linear, and how to use it to extrapolate solubility to 0 % cosolvent. We demonstrate that the MDM mixture (1:1:1 methanol, acetonitrile and dioxane) provides linear logS - cosolvent relationship for all tested compounds, and excellent extrapolation abilities. Our method opens the way to the systematic determination of very low solubilities at the very first stages of drug design programs, a valuable input for structure-property relationship studies.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 6,
  "authors": [
    {
      "name": "Dimitri Fayolle"
    },
    {
      "name": "Marie Emilie Mwakondet"
    },
    {
      "name": "Marianne Carpentier"
    },
    {
      "name": "Jana Sopkova - de Oliveira Santos"
    },
    {
      "name": "Anne Sophie Voisin-Chiret"
    },
    {
      "name": "Marc Since"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/2nr4qecs4y2h3.bib",
  "cited_by": 0,
  "doi": "10.1016/j.ijpharm.2026.127325",
  "fulltext_url": null,
  "id": "2nr4qecs4y2h3",
  "issns": [
    "0378-5173"
  ],
  "landing_url": "https://normandie-univ.hal.science/hal-05767834v1",
  "language": "en",
  "licence": "CC-BY-NC",
  "licence_label": "CC BY-NC",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by-nc/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "hal",
      "0.chim"
    ],
    [
      "hal",
      "1.chim.anal"
    ],
    [
      "openalex",
      "3003|Drug Solubulity and Delivery Systems"
    ]
  ],
  "openalex": "W7203737943",
  "pdf_url": null,
  "pmcid": null,
  "pmid": null,
  "published": "2026-09-28",
  "publisher": "Elsevier",
  "ris": "https://research.draconitic.com/paper/2nr4qecs4y2h3.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:42Z",
      "native_id": "hal-05767834",
      "source": "hal",
      "url": "https://normandie-univ.hal.science/hal-05767834v1"
    }
  ],
  "subjects": [
    {
      "field": "chemistry",
      "origin": "hal:1.chim.anal",
      "subfield": "analytical"
    }
  ],
  "title": "Rapid and accurate solubility determination of poorly soluble drug molecules by co-solvent extrapolation",
  "title_text": "Rapid and accurate solubility determination of poorly soluble drug molecules by co-solvent extrapolation",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:17:42Z",
  "url": "https://research.draconitic.com/paper/2nr4qecs4y2h3",
  "venue": "International Journal of Pharmaceutics",
  "versions": []
}