{
  "abstract": "BACKGROUND: The current study aimed to identify the multivariate trajectories of cardiometabolic risk factors in elderly patients with type 2 diabetes and investigate their associations with cardiovascular disease and diabetic kidney disease (DKD). METHODS: A retrospective cohort of 27 288 patients with type 2 diabetes aged ≥60 years from China's National Basic Public Health Service Program was analyzed. All participants had ≥3 medical examinations from 2018 to 2023. A multivariate latent class mixed model was used to identify the sex-specific multitrajectories of fasting plasma glucose, low-density lipoprotein cholesterol, and diastolic blood pressure. Binary logistic regression estimated odds ratios (ORs) and 95% CIs for associations with cardiovascular disease, coronary heart disease, stroke, and DKD. RESULTS: Among elderly male patients, 3 quadratic trajectory groups were identified: stable (87.16%; n=7997), U shape (3.78%; n=347), and inverse U shape (9.06%; n=831). In elderly women, 2 quadratic trajectory groups were identified: stable (87.29%; n=15 810) and inverse U shape (12.71%; n=2303). In men, the U-shape group had elevated risks of cardiovascular disease (OR, 1.66 [95% CI, 1.26-2.20]), coronary heart disease (OR, 1.60 [95% CI, 1.09-2.33]), stroke (OR, 1.58 [95% CI, 1.12-2.23]), and DKD (OR, 1.39 [95% CI, 1.11-1.74]); the inverse U-shape group had increased DKD risk (OR, 1.35 [95% CI, 1.16-1.57]). In women, the inverse U-shape group was associated with coronary heart disease (OR, 1.31 [95% CI, 1.12-1.53]) and DKD (OR, 1.65 [95% CI, 1.51-1.81]). CONCLUSIONS: Distinct sex-specific trajectories of cardiometabolic risk factors were associated with different risks of cardiovascular and diabetic kidney complications in elderly patients with type 2 diabetes. These findings support early identification and personalized management of adverse trajectories to potentially reduce long-term complications in this population.",
  "abstract_shown": true,
  "affiliations": [
    "Nanjing Municipal Center for Disease Control and Prevention",
    "Huadong Hospital, Fudan University",
    "Collaborative Innovation Center for Cancer Personalized Medicine, School of Public Health, Nanjing Medical University"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 9,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Yijia Chen"
    },
    {
      "affs": [
        1
      ],
      "name": "Yichao Chen",
      "orcid": "0009-0005-8657-3938"
    },
    {
      "affs": [
        0
      ],
      "name": "Weiwei Wang"
    },
    {
      "affs": [
        0
      ],
      "name": "Hairong Zhou"
    },
    {
      "affs": [
        0
      ],
      "name": "Huafeng Yang"
    },
    {
      "affs": [
        0
      ],
      "name": "Qiannan Sun"
    },
    {
      "affs": [
        1
      ],
      "name": "Jun Tang"
    },
    {
      "affs": [
        2
      ],
      "name": "Dong Hang",
      "orcid": "0000-0001-6944-0459"
    },
    {
      "affs": [
        0
      ],
      "name": "Xin Hong",
      "orcid": "0000-0002-0561-2829"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/2nvpbxqwrmbyt.bib",
  "cited_by": 0,
  "doi": "10.1161/jaha.125.047911",
  "fulltext_url": null,
  "id": "2nvpbxqwrmbyt",
  "issns": [
    "2047-9980"
  ],
  "landing_url": "https://www.ahajournals.org/doi/10.1161/JAHA.125.047911",
  "language": null,
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2712|Diabetes, Cardiovascular Risks, and Lipoproteins"
    ]
  ],
  "openalex": "W7223273345",
  "pdf_url": null,
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-23",
  "publisher": "Ovid Technologies (Wolters Kluwer Health)",
  "ris": "https://research.draconitic.com/paper/2nvpbxqwrmbyt.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:20:28Z",
      "native_id": "10.1161/jaha.125.047911",
      "source": "crossref",
      "url": "https://www.ahajournals.org/doi/10.1161/JAHA.125.047911"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2712|Diabetes, Cardiovascular Risks, and Lipoproteins",
      "subfield": "endocrinology-metabolism"
    }
  ],
  "title": "Multivariate Trajectories of Cardiometabolic Risk Factors and Complications in Elderly Chinese Patients With Type 2 Diabetes: A Retrospective Cohort Study",
  "title_text": "Multivariate Trajectories of Cardiometabolic Risk Factors and Complications in Elderly Chinese Patients With Type 2 Diabetes: A Retrospective Cohort Study",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:20:28Z",
  "url": "https://research.draconitic.com/paper/2nvpbxqwrmbyt",
  "venue": "Journal of the American Heart Association",
  "versions": []
}