{
  "abstract": "A 32-yr-old woman presented with a 2-year history of progressive bone pain, proximal muscle weakness, worsening ambulation, and bilateral hip insufficiency fractures without preceding trauma. Laboratory evaluation revealed severe hypophosphatemia (1.1 mg/dL), elevated bone-specific alkaline phosphatase, progressive secondary hyperparathyroidism, and inappropriately elevated circulating FGF-23, with fasting paired serum and urine studies confirming renal phosphate wasting (tubular maximum phosphate reabsorption per glomerular filtration rate 1.88 mg/dL; fractional excretion of phosphate 14.6%), consistent with tumor-induced osteomalacia (TIO). Functional imaging with ⁶⁸Ga-DOTATATE PET/CT demonstrated intense tracer uptake in a small anterior cranial lesion. Brain MRI revealed a dural-based olfactory groove lesion interpreted radiographically as a meningioma. Selective venous sampling demonstrated a cranial-to-peripheral gradient in intact FGF-23 consistent with drainage from the anterior cranial fossa. Surgical resection produced postoperative normalization of FGF-23 and rapid correction of hypophosphatemia. Histology showed meningioma-like architecture with whorls and psammoma bodies, but expanded molecular testing did not identify canonical meningioma-associated alterations, and DNA methylation profiling classified the lesion as a mesenchymal neoplasm not elsewhere classified and fusion negative. FGF-23 in situ hybridization was positive, and the final surgical pathology diagnosis was mesenchymal tumor favoring phosphaturic mesenchymal tumor over meningioma. This case illustrates how a mesenchymal tumor arising in the meninges can mimic meningioma radiographically and histologically while producing the endocrine phenotype of TIO.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Medicine, Division of Endocrinology, Hartford Hospital, Hartford, CT 06102, United States.",
    "Department of Radiology, Hartford Hospital, Hartford, CT 06102, United States.",
    "Department of Neurosurgery, Hartford Hospital, Hartford, CT 06102, United States.",
    "Department of Pathology, Hartford Hospital, Hartford, CT 06102, United States."
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 6,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Samaneh Rabiei",
      "orcid": "0009-0006-7147-167X"
    },
    {
      "affs": [
        1
      ],
      "name": "Daniel Collins",
      "orcid": "0009-0000-5296-1362"
    },
    {
      "affs": [
        2
      ],
      "name": "Paul Schwartz",
      "orcid": "0009-0001-4968-4461"
    },
    {
      "affs": [
        3
      ],
      "name": "Antonella Pallante",
      "orcid": "0009-0009-0404-8646"
    },
    {
      "affs": [
        3
      ],
      "name": "Xianyuan Song",
      "orcid": "0009-0007-4519-3554"
    },
    {
      "affs": [
        0
      ],
      "name": "Vitaly Kantorovich",
      "orcid": "0000-0003-2220-4904"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/2ny6hfd30fdw2.bib",
  "cited_by": 0,
  "doi": "10.1093/jbmrpl/ziag156",
  "fulltext_url": "https://europepmc.org/articles/PMC13704789",
  "id": "2ny6hfd30fdw2",
  "issns": [
    "2473-4039"
  ],
  "landing_url": "https://europepmc.org/article/MED/42936393",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2727|Parathyroid Disorders and Treatments"
    ]
  ],
  "openalex": "W7213450710",
  "pdf_url": "https://europepmc.org/articles/PMC13704789?pdf=render",
  "pmcid": "PMC13704789",
  "pmid": "42936393",
  "published": "2026-09-17",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/2ny6hfd30fdw2.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:22:24Z",
      "native_id": "MED:42936393",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42936393"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2727|Parathyroid Disorders and Treatments",
      "subfield": "general"
    }
  ],
  "title": "Intracranial phosphaturic mesenchymal tumor mimicking meningioma and causing tumor-induced osteomalacia: a case report.",
  "title_text": "Intracranial phosphaturic mesenchymal tumor mimicking meningioma and causing tumor-induced osteomalacia: a case report.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:22:24Z",
  "url": "https://research.draconitic.com/paper/2ny6hfd30fdw2",
  "venue": "JBMR plus",
  "versions": []
}