{
  "abstract": "Herein, a supramolecular ternary deep eutectic solvent coupled with in-situ ultrasound-assisted extraction (STDES-ISUSE) was developed to extract lobetyolin (LBT) in Codonopsis tangshen. The hydroxypropyl-β-cyclodextrin: lactic acid: glycerol (HP-β-CD: LA: Gly) system stood out to extract LBT among the twenty formulations tested. The optimal extraction conditions—water content of 46% (v/v), liquid/solid ratio of 29 mL/g, ultrasound time of 34 min, ultrasound power of 240 W, and vortex time of 10 min—were established via a hybrid response surface methodology-artificial neural network-genetic algorithm (RSM-ANN-GA) paradigm. Under these conditions, the LBT yield reached 0.613 ± 0.011 mg/g, significantly exceeding that of conventional methods. Twenty compounds were identified via UHPLC-Q-TOF-MS, encompassing two phenolic acids, two polyacetylenic glycosides, five fatty acids, two glycosides, one iridoids, and one alkaloids, while a tailored HPLC method enabled precise LBT quantification. Mechanistic investigations, combining FT-IR corroboration of STDES fabrication, SEM visualization, and MD simulations, collectively revealed that the STDES-ISUSE approach potentiates extraction through synergistic cell-wall disintegration and enhanced LBT solubilization. In vitro antioxidant testing further substantiated the bioactivity of the extracts. In summary, this work delivers a green, high-efficiency extraction protocol for bioactive targets from C. tangshen, offering a practical route toward sustainable phytochemical recovery and the broader implementation of green extraction practices in natural product research.",
  "abstract_shown": true,
  "affiliations": [
    "College of Biological and Chemical Engineering, Chongqing University of Education, Chongqing 400067, China",
    "Chongqing Academy of Chinese Materica Medica, Chongqing, China",
    "Agricultural Development Service Center of Kaizhou District, Chongqing, China",
    "Shandong Baiweitang Traditional Chinese Medicine Decoction Pieces Co., Ltd., China",
    "Agricultural Technology Extension Center of Pingyi County, Linyi City, Shandong Province, China"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 14,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Cheng Liu"
    },
    {
      "affs": [
        1
      ],
      "name": "Yiquan Zhou"
    },
    {
      "affs": [
        2
      ],
      "name": "Jin Guo"
    },
    {
      "affs": [
        2
      ],
      "name": "Yijia Chen"
    },
    {
      "affs": [
        3
      ],
      "name": "Xia Zhao"
    },
    {
      "affs": [
        4
      ],
      "name": "Zhiqiang Chen"
    },
    {
      "affs": [
        0
      ],
      "name": "Xin Zhao"
    },
    {
      "affs": [
        0
      ],
      "name": "Xiaochuan Zou"
    },
    {
      "affs": [
        0
      ],
      "name": "Fangyuan Gong"
    },
    {
      "affs": [
        0
      ],
      "name": "Ailing Lei"
    },
    {
      "affs": [
        0
      ],
      "name": "Shuxin He"
    },
    {
      "affs": [
        0
      ],
      "name": "Xin Ma"
    },
    {
      "affs": [
        0
      ],
      "name": "Xinyu Liu"
    },
    {
      "affs": [
        0
      ],
      "name": "Jie Lei"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/2p492w3zsbzty.bib",
  "cited_by": 0,
  "doi": "10.1016/j.ultsonch.2026.108126",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13737721/",
  "id": "2p492w3zsbzty",
  "issns": [
    "1350-4177",
    "1873-2828"
  ],
  "landing_url": "https://doi.org/10.1016/j.ultsonch.2026.108126",
  "language": "en",
  "licence": "CC-BY-NC-ND-4.0",
  "licence_label": "CC BY-NC-ND 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Original Research Article"
    ],
    [
      "openalex",
      "1606|Ionic liquids properties and applications"
    ]
  ],
  "openalex": "W7223134031",
  "pdf_url": "https://www.sciencedirect.com/science/article/pii/S1350417726003913/pdf",
  "pmcid": "PMC13737721",
  "pmid": "42950778",
  "published": "2026-10-21",
  "publisher": "Elsevier",
  "ris": "https://research.draconitic.com/paper/2p492w3zsbzty.ris",
  "sources": [
    {
      "first_seen": "2026-11-09T12:22:50Z",
      "native_id": "PMC13737721",
      "source": "pmc",
      "url": "https://doi.org/10.1016/j.ultsonch.2026.108126"
    }
  ],
  "subjects": [
    {
      "field": "chemistry",
      "origin": "openalex:1606|Ionic liquids properties and applications",
      "subfield": "physical"
    }
  ],
  "title": "Synergistic ultrasound- and vortex-assisted extraction of lobetyolin from Codonopsis tangshen using a supramolecular ternary deep eutectic solvent: yield optimization and antioxidant activity evaluation",
  "title_text": "Synergistic ultrasound- and vortex-assisted extraction of lobetyolin from Codonopsis tangshen using a supramolecular ternary deep eutectic solvent: yield optimization and antioxidant activity evaluation",
  "type": "peer-reviewed",
  "updated_at": "2026-11-09T12:22:50Z",
  "url": "https://research.draconitic.com/paper/2p492w3zsbzty",
  "venue": "Ultrasonics Sonochemistry",
  "versions": []
}