{
  "abstract": "Objective\n\nThe study objective was to evaluate the efficacy and feasibility of left ventricular reshaping in a swine model of late-stage ischemic heart failure with marked left ventricular dilation and functional mitral regurgitation.Methods\n\nA chronic heart failure model with ischemic mitral regurgitation was established in 8 Yorkshire swine via percutaneous injection of 100% ethanol into the left circumflex artery. The left ventricular reshaping device was implanted transapically at 6 months postinfarction and evaluated with echocardiography and pressure-volume loop analysis. The final efficacy analysis included 7 animals.Results\n\nThe device was successfully implanted and significantly reduced mitral regurgitation (regurgitant volume: 43.29 ± 14.47 mL vs 9.90 ± 5.12 mL, P = .0026). Posterior excursion angle (22.71 ± 6.92° vs 39.14 ± 7.29°, P = .0042) and coaptation length (2.72 ± 0.44 mm vs 4.42 ± 0.76 mm, P = .0033) increased significantly. Left ventricular volume significantly decreased after reshaping (indexed end-diastolic volume: 140.30 ± 28.28 mL/m² vs 84.68 ± 18.51 mL/m², P = .0019; indexed end-systolic volume: 91.54 ± 24.01 mL/m² vs 48.23 ± 16.25 mL/m², P = .0003). Ejection fraction significantly increased (33.71% ± 3.30% vs 43.43% ± 7.12%, P = .0046), whereas load-independent indices of systolic function and measures of diastolic function did not change significantly.Conclusions\n\nTransapical left ventricular reshaping demonstrated acute efficacy and feasibility at 6 months postinfarction in advanced heart failure by reducing left ventricular volume and mitral regurgitation.",
  "abstract_shown": true,
  "affiliations": [
    "Center for Regenerative Medicine, Research Institute at Nationwide Children's Hospital, Columbus, Ohio.",
    "Division of Plastic Surgery, Department of Surgery, McMaster University, Hamilton, Ontario, Canada.",
    "Lee Moffitt Cancer Center & Research Institute, Comparative Medicine Core Facility, Tampa, Fla.",
    "Department of Pediatrics, The Ohio State University College of Medicine, Columbus, Ohio."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 10,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Kosuke Nakamae"
    },
    {
      "affs": [
        0
      ],
      "name": "Chihiro Miyagi"
    },
    {
      "affs": [
        0
      ],
      "name": "Junya Matsuda"
    },
    {
      "affs": [
        0
      ],
      "name": "Syed Faizullah Hussaini"
    },
    {
      "affs": [
        0
      ],
      "name": "Tatsuya Watanabe"
    },
    {
      "affs": [
        0
      ],
      "name": "Satoshi Yuhara"
    },
    {
      "affs": [
        0
      ],
      "name": "Adrienne Morrison"
    },
    {
      "affs": [
        0
      ],
      "name": "Kirsten Nelson"
    },
    {
      "affs": [
        1,
        2
      ],
      "name": "Filip Konecny"
    },
    {
      "affs": [
        0,
        3
      ],
      "name": "Daisuke Onohara"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/2p5y5rk1p8bze.bib",
  "cited_by": 0,
  "doi": "10.1016/j.xjon.2026.102080",
  "fulltext_url": "https://europepmc.org/articles/PMC13711409",
  "id": "2p5y5rk1p8bze",
  "issns": [
    "2666-2736"
  ],
  "landing_url": "https://europepmc.org/article/MED/42948581",
  "language": "eng",
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Adult: Mitral Valve: Basic Science"
    ]
  ],
  "openalex": null,
  "pdf_url": "https://europepmc.org/articles/PMC13711409?pdf=render",
  "pmcid": "PMC13711409",
  "pmid": "42948581",
  "published": "2026-08-23",
  "publisher": "Elsevier",
  "ris": "https://research.draconitic.com/paper/2p5y5rk1p8bze.ris",
  "sources": [
    {
      "first_seen": "2026-10-31T00:20:35Z",
      "native_id": "MED:42948581",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42948581"
    },
    {
      "first_seen": "2026-10-31T12:22:11Z",
      "native_id": "PMC13711409",
      "source": "pmc",
      "url": "https://doi.org/10.1016/j.xjon.2026.102080"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "journal-openalex:F27",
      "subfield": "general"
    }
  ],
  "title": "Impact of left ventricular reshaping on postinfarction functional mitral regurgitation in a chronic swine model of advanced heart failure.",
  "title_text": "Impact of left ventricular reshaping on postinfarction functional mitral regurgitation in a chronic swine model of advanced heart failure.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-31T12:22:11Z",
  "url": "https://research.draconitic.com/paper/2p5y5rk1p8bze",
  "venue": "JTCVS open",
  "versions": []
}