{
  "abstract": "Background\n\nPSMA PET/CT plays an important role in biochemically recurrent prostate cancer (BCR-PCa). In general, PET/CT is performed as a limited or true whole-body examination. The majority of PET/CT scanners operate by measuring several bed positions or continuous motion with a limited axial field of view (FOV). Shortening the scan area thus results in a time saving, with unknown information loss regarding the detection of tumor manifestations.Methodology\n\nThis retrospective single-center study included 200 patients with BCR-PCa after initial curative therapy who underwent a ⁶⁸Ga-PSMA-PET/CT scan from vertex to toe (true whole-body). Using retrospective subdivision into hypothetical partial body measurement protocols, the undetected tumor manifestations were examined. Classic PET/CT protocols were used: vertex to mid-thigh, skull base to mid-thigh, as well as CT-equivalent examination areas: chest/abdomen/pelvis (CAP), abdomen/pelvis (AP) and pelvis.Results\n\nOf 200 patients with a median PSA of 1.1 ng/mL, 128 (64%) showed at least one structural correlate of BCR-PCa in the true whole-body scan. The overall detection rate did not change for limited classic PET-protocols, or CAP measurements. CAP scans would not have detected all tumor manifestations in 16 patients (8%) and not all tumor-affected organ systems in six patients (3%), AP scans in 41 patients (21%) and 18 patients (9%), pelvic scans in 61 patients (31%) and 37 patients (19%), respectively. PSA may contribute to the prospective restriction of the scan area. Patients with PSA ≤ 0.75 ng/mL showed no diagnostic gain from whole-body imaging. This means that in 45% of patients in our cohort, a limitation to CAP scan would have been possible without losing information.Conclusions\n\nFor a resource-saving use of routine PSMA-PET/CT, a scan from the vertex to the mid-thigh seems sufficient for detecting relevant metastases. For patients with low PSA levels, a more focused protocol that includes only the CAP region can be considered.",
  "abstract_shown": true,
  "affiliations": [
    "University Hospital Jena, Clinic of Nuclear Medicine, Am Klinikum 1, 07747, Jena, Germany.",
    "University Hospital Jena, Clinic of Nuclear Medicine, Am Klinikum 1, 07747, Jena, Germany. martin.freesmeyer@med.uni-jena.de."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 5,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Falk Gühne"
    },
    {
      "affs": [
        0
      ],
      "name": "Alexander Küppers"
    },
    {
      "affs": [
        0
      ],
      "name": "Christian Kühnel"
    },
    {
      "affs": [
        0
      ],
      "name": "Philipp Seifert"
    },
    {
      "affs": [
        1
      ],
      "name": "Martin Freesmeyer"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/2pr6ejea7bcpr.bib",
  "cited_by": 0,
  "doi": "10.1186/s12880-026-02940-w",
  "fulltext_url": "https://europepmc.org/articles/PMC13685216",
  "id": "2pr6ejea7bcpr",
  "issns": [
    "1471-2342"
  ],
  "landing_url": "https://europepmc.org/article/MED/42907742",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "lcc",
      "R855-855.5"
    ],
    [
      "openalex",
      "2741|Medical Imaging Techniques and Applications"
    ]
  ],
  "openalex": "W7223158630",
  "pdf_url": "https://europepmc.org/articles/PMC13685216?pdf=render",
  "pmcid": "PMC13685216",
  "pmid": "42907742",
  "published": "2026-10-21",
  "publisher": "BMC",
  "ris": "https://research.draconitic.com/paper/2pr6ejea7bcpr.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:19:53Z",
      "native_id": "MED:42907742",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42907742"
    },
    {
      "first_seen": "2026-10-30T13:46:34Z",
      "native_id": "95d79cde236c4f44beaa0a6be101ceb4",
      "source": "doaj",
      "url": "https://doi.org/10.1186/s12880-026-02940-w"
    }
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  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2741|Medical Imaging Techniques and Applications",
      "subfield": "imaging"
    }
  ],
  "title": "Impact of reduced scan extent on tumor detection in ⁶⁸Ga-PSMA PET/CT for biochemical recurrence of prostate cancer.",
  "title_text": "Impact of reduced scan extent on tumor detection in ⁶⁸Ga-PSMA PET/CT for biochemical recurrence of prostate cancer.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T13:46:34Z",
  "url": "https://research.draconitic.com/paper/2pr6ejea7bcpr",
  "venue": "BMC medical imaging",
  "versions": []
}