{
  "abstract": "Semaglutide is widely used for metabolic disease, but cutaneous adverse events are inconsistently reported. This systematic review and meta-analysis evaluated randomized comparisons of semaglutide with placebo, usual care, or non-semaglutide active treatment. The protocol was registered in the International Prospective Register of Systematic Reviews (PROSPERO; CRD420261464289). PubMed, Europe PubMed Central, trial registers, sponsor reports, and regulatory sources were examined through September 9, 2026; source verification was completed on September 21, 2026. Meta-analysis required directly available, source-verified participant event counts and denominators in both groups. Reported alopecia or hair loss and source-defined participant-level injection-site reactions were analyzed separately using common-effect Mantel-Haenszel odds ratios (ORs) without continuity correction. Risk of bias and evidence certainty were assessed for the primary syntheses. Thirty-one trials contributed verified outcome data. Twenty trials formed the primary placebo/common-control evidence set, of which 19 contributed relative-effect estimates and one reported zero injection-site reactions in both groups. Eleven additional trials provided active-comparator or design-specific evidence. Across nine comparisons, alopecia or hair loss was reported in 191/11,564 semaglutide recipients and 36/9,799 comparators (OR: 2.92, 95% confidence interval (CI): 1.99-4.27; p < 0.001; low-certainty evidence). The association persisted after exclusion of the largest cardiovascular outcomes trial with restricted ascertainment; random-effects analyses supported the primary interpretations. Eleven informative comparisons reported injection-site reactions in 156/5,066 semaglutide recipients and 114/3,483 comparators (OR: 0.86, 95% CI: 0.67-1.11; p = 0.256; very-low-certainty evidence). Active comparators and design-specific results were described separately. Semaglutide may increase reports of alopecia or hair loss; its comparative effect on injection-site reactions remains uncertain. Available-count synthesis does not resolve selective non-reporting or incomplete event ascertainment. The findings do not establish a hair-loss mechanism or injection-site safety equivalence.",
  "abstract_shown": true,
  "affiliations": [
    "Dermatology, Raipur Institute of Medical Sciences, Raipur, IND",
    "Community Medicine, Ram Krishna Medical College Hospital and Research Centre, Bhopal, IND"
  ],
  "article_type": "review article",
  "arxiv": null,
  "author_total": 3,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Samyak Ganjre"
    },
    {
      "affs": [
        0
      ],
      "name": "Liza Borah"
    },
    {
      "affs": [
        1
      ],
      "name": "Archit Khardenavis"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/2qmqbvmz70dze.bib",
  "cited_by": 0,
  "doi": "10.7759/cureus.117270",
  "fulltext_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13722923/?tool=EBI",
  "id": "2qmqbvmz70dze",
  "issns": [
    "2168-8184"
  ],
  "landing_url": "https://europepmc.org/article/PMC/PMC13722923",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Dermatology"
    ],
    [
      "heading",
      "Endocrinology/Diabetes/Metabolism"
    ],
    [
      "heading",
      "Pharmacology"
    ],
    [
      "openalex",
      "2712|Diabetes Treatment and Management"
    ]
  ],
  "openalex": "W7215108471",
  "pdf_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13722923/pdf/?tool=EBI",
  "pmcid": "PMC13722923",
  "pmid": "42966951",
  "published": "2026-09-30",
  "publisher": "Cureus Inc.",
  "ris": "https://research.draconitic.com/paper/2qmqbvmz70dze.ris",
  "sources": [
    {
      "first_seen": "2026-11-02T03:21:51Z",
      "native_id": "PMC:PMC13722923",
      "source": "europepmc",
      "url": "https://europepmc.org/article/PMC/PMC13722923"
    },
    {
      "first_seen": "2026-11-04T12:21:38Z",
      "native_id": "PMC13722923",
      "source": "pmc",
      "url": "https://doi.org/10.7759/cureus.117270"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "heading:Pharmacology",
      "subfield": "pharmacology-toxicology"
    }
  ],
  "title": "Cutaneous Adverse Events With Semaglutide: A Systematic Review and Meta-Analysis of Randomized Controlled Trials",
  "title_text": "Cutaneous Adverse Events With Semaglutide: A Systematic Review and Meta-Analysis of Randomized Controlled Trials",
  "type": "peer-reviewed",
  "updated_at": "2026-11-04T12:21:38Z",
  "url": "https://research.draconitic.com/paper/2qmqbvmz70dze",
  "venue": "Cureus",
  "versions": []
}