{
  "abstract": "Introduction: Autoimmune connective tissue diseases (AICTDs) are associated with both chronic inflammation and an increased risk of atherosclerotic cardiovascular disease beyond that conferred by traditional risk factors. High-density lipoprotein (HDL) exerts anti-atherogenic effects through its cholesterol efflux capacity (CEC), which inflammation may impair. Although HDL dysfunction has been reported in AICTDs, the role of this dysfunction in connective tissue diseases has not yet been systematically evaluated.\n\nMethods and analysis: The study protocol was registered in the International Prospective Register of Systematic Reviews (CRD420251183500). From inception, the Medical Literature Analysis and Retrieval System Online, Excerpta Medica database and the Cochrane Central Register of Controlled Trials will be searched. The review is scheduled to run from October 2026 to August 2027. Observational and interventional studies in adults with AICTDs reporting quantitative measures of HDL functionality, including CEC, antioxidant capacity, anti-inflammatory function and endothelial protective function, will be included. The study will be independently conducted by two reviewers.\n\nEthics and dissemination: Because this study will be a systematic review based on previously published data and will not involve individual patient data, ethical approval is not required. The findings will be disseminated through publication in a peer-reviewed journal and will be presented at a conference.\n\nPROSPERO registration number: CRD420251183500.",
  "abstract_shown": true,
  "affiliations": [
    "Faculty of Medical Technology, Niigata University of Pharmacy, Niigata, Japan",
    "Department of Clinical Laboratory Medicine, Juntendo University Graduate School of Medicine, Tokyo, Japan",
    "Department of Clinical Laboratory Technology, Juntendo University, Tokyo, Japan"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 3,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Yasuhiro Endo",
      "orcid": "0000-0002-4065-9868"
    },
    {
      "affs": [
        1
      ],
      "name": "Kei Sasaki"
    },
    {
      "affs": [
        2
      ],
      "name": "Masatsune Ogura"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/2rpqqm89p3r02.bib",
  "cited_by": 0,
  "doi": "10.1136/bmjopen-2026-122567",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13723838/",
  "id": "2rpqqm89p3r02",
  "issns": [
    "2044-6055",
    "2044-6055"
  ],
  "landing_url": "https://bmjopen.bmj.com/lookup/doi/10.1136/bmjopen-2026-122567",
  "language": "en",
  "licence": "CC-BY-NC-4.0",
  "licence_label": "CC BY-NC 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "1506"
    ],
    [
      "heading",
      "1683"
    ],
    [
      "heading",
      "Cardiovascular Medicine"
    ],
    [
      "heading",
      "Protocol"
    ]
  ],
  "openalex": null,
  "pdf_url": null,
  "pmcid": "PMC13723838",
  "pmid": "42957295",
  "published": "2026-10-29",
  "publisher": "BMJ",
  "ris": "https://research.draconitic.com/paper/2rpqqm89p3r02.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:19:44Z",
      "native_id": "10.1136/bmjopen-2026-122567",
      "source": "crossref",
      "url": "https://bmjopen.bmj.com/lookup/doi/10.1136/bmjopen-2026-122567"
    },
    {
      "first_seen": "2026-11-04T12:22:24Z",
      "native_id": "PMC13723838",
      "source": "pmc",
      "url": "https://doi.org/10.1136/bmjopen-2026-122567"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "heading:Cardiovascular Medicine",
      "subfield": "cardiovascular"
    }
  ],
  "title": "High-density lipoprotein (HDL) dysfunctionality in autoimmune connective tissue diseases: protocol for a systematic review",
  "title_text": "High-density lipoprotein (HDL) dysfunctionality in autoimmune connective tissue diseases: protocol for a systematic review",
  "type": "peer-reviewed",
  "updated_at": "2026-11-05T12:20:35Z",
  "url": "https://research.draconitic.com/paper/2rpqqm89p3r02",
  "venue": "BMJ Open",
  "versions": []
}