{
  "abstract": "Introduction: The myocardial ischemia-reperfusion injury (IRI) is an indispensable factor in pediatric congenital heart defect (CHD) surgery. Although effective myocardial protection strategies are crucial, the issue remains a dilemma. This study aimed to evaluate the effect of adding dexmedetomidine to modified Del Nido cardioplegia on myocardial protection in children undergoing CHD surgery.\n\nMethods: This was a prospective, randomized, triple-blind, controlled clinical trial. A total of 60 pediatric patients were enrolled and randomized 1:1 into two groups - an intervention group that received dexmedetomidine-enriched modified Del Nido cardioplegia and a control group that received standard modified Del Nido cardioplegia with normal saline. Primary outcomes included serum troponin I and creatine kinase-MB levels, as well as coronary sinus lactate levels. Secondary outcomes were the vasoactive-inotropic score, weaning time from mechanical ventilation, and intensive care unit length of stay.\n\nResults: Adding dexmedetomidine to modified Del Nido cardioplegia significantly improved myocardial protection in children undergoing CHD surgery. The intervention group showed significantly lower troponin I levels at all postoperative time points compared to the control group (P < 0.001). Similarly, the dexmedetomidine group had significantly lower vasoactive-inotropic score at all time points (P < 0.001). Patients in the intervention group also experienced a significantly shorter mean ventilator weaning time (P < 0.001) and intensive care unit stay duration (P < 0.001). The overall distribution of postoperative morbidities did not differ significantly between the groups (P = 0.059).\n\nConclusion: Adding dexmedetomidine to modified Del Nido cardioplegia significantly improved myocardial protection in children undergoing corrective CHD surgery.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Extra-Corporeal Circulation (ECC), Imam Reza Hospital, Mashhad University of Medical Sciences, Mashhad, Iran",
    "Department of Cardiac Surgery, Imam Reza Hospital, Mashhad University of Medical Sciences, Mashhad, Iran",
    "Department of General Surgery, School of Medicine, Torbat Heydariyeh University of Medical Sciences, Torbat Heydariyeh, Iran",
    "Pediatric and Congenital Cardiology Division, Department of Pediatrics, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran",
    "Department of Anesthesiology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran",
    "Department of Extra-Corporeal Circulation (ECC), Razavi Hospital, Imam Reza International University, Mashhad, Iran"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 7,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Farhad Samadieh"
    },
    {
      "affs": [
        1
      ],
      "name": "Mahmood Hosseinzadeh Maleki"
    },
    {
      "affs": [
        2
      ],
      "name": "Masoud Razeghian"
    },
    {
      "affs": [
        0
      ],
      "name": "Tahereh Izanlou"
    },
    {
      "affs": [
        3
      ],
      "name": "Mohammadreza Naghibi Sistani"
    },
    {
      "affs": [
        4
      ],
      "name": "Benyamin Fazli"
    },
    {
      "affs": [
        5
      ],
      "name": "Mohsen Yaghubi"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/2rqjrk2prs12b.bib",
  "cited_by": 0,
  "doi": "10.21470/1678-9741-2025-0415",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13741879/",
  "id": "2rqjrk2prs12b",
  "issns": [
    "0102-7638",
    "1678-9741"
  ],
  "landing_url": "https://doi.org/10.21470/1678-9741-2025-0415",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Original Article"
    ],
    [
      "openalex",
      "2746|Cardiac and Coronary Surgery Techniques"
    ]
  ],
  "openalex": "W7225326635",
  "pdf_url": null,
  "pmcid": "PMC13741879",
  "pmid": "42981171",
  "published": "2026-09-08",
  "publisher": "Sociedade Brasileira de Cirurgia Cardiovascular",
  "ris": "https://research.draconitic.com/paper/2rqjrk2prs12b.ris",
  "sources": [
    {
      "first_seen": "2026-11-10T12:22:50Z",
      "native_id": "PMC13741879",
      "source": "pmc",
      "url": "https://doi.org/10.21470/1678-9741-2025-0415"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2746|Cardiac and Coronary Surgery Techniques",
      "subfield": "surgery"
    }
  ],
  "title": "The Effect of Adding Dexmedetomidine to Modified Del Nido Cardioplegia Solution on Myocardial Protection in Children Undergoing Congenital Heart Defect Surgery - A Prospective, Randomized, Triple-Blind, Controlled Trial",
  "title_text": "The Effect of Adding Dexmedetomidine to Modified Del Nido Cardioplegia Solution on Myocardial Protection in Children Undergoing Congenital Heart Defect Surgery - A Prospective, Randomized, Triple-Blind, Controlled Trial",
  "type": "peer-reviewed",
  "updated_at": "2026-11-10T12:22:50Z",
  "url": "https://research.draconitic.com/paper/2rqjrk2prs12b",
  "venue": "Brazilian Journal of Cardiovascular Surgery",
  "versions": []
}