{
  "abstract": "Introduction\n\nAlthough first-line immune-based combinations have reshaped the management of metastatic renal cell carcinoma (mRCC), relevant unmet clinical needs remain. Sarcomatoid feature is a negative prognostic factor that confers sensitivity to immunotherapy, yet the optimal ICI combination in this subgroup is still unclear.Methods\n\nThe Meet-URO 33 is an Italian multicenter retrospective/prospective observational study enrolling patients with mRCC receiving first-line systemic therapy in routine clinical practice. In the present sub-analysis, objective response and survival outcomes were compared between ICI-ICI and ICI-TKI regimens in patients with documented sarcomatoid differentiation and IMDC intermediate-/poor-risk disease.Results\n\nAmong 1695 patients enrolled from 58 centers, 180 (10.6%) had sRCC and among them, 107 (58.2%) were intermediate-risk and 56 (30.4%) were poor-risk. With a median follow-up of 21.8 months, in the I/P-sRCC population with available data (n = 155), univariable analysis showed longer overall survival (OS) with ICI-ICI compared to ICI-TKI (HR 0.58, p = 0.04). However, in propensity score-weighted analyses, point estimates slightly favored ICI-ICI, but no statistically significant differences were observed for OS, PFS, or ORR.Conclusions\n\nIn this real-world analysis comparing ICI-ICI and ICI-TKI in sarcomatoid mRCC, propensity score-weighted models showed no statistically significant differences between treatment combinations on clinical outcomes. These findings highlight the relevance of baseline disease and patients characteristics in shaping treatment outcomes and confirm the effectiveness of ICI-containing combinations in the treatment of sarcomatoid mRCC.",
  "abstract_shown": true,
  "affiliations": [
    "Medical Oncology Unit 2, Ospedale Molinette, Azienda Ospedaliero-Universitaria Città della Salute e della Scienza di Torino, Turin, Italy.",
    "Department of Clinical Medicine and Surgery, University of Naples \"Federico II\", Naples, Italy.",
    "Translational and Clinical Research Institute, Centre for Cancer, Newcastle University, Newcastle upon Tyne, UK.",
    "Medical Oncology 1U, Azienda Ospedaliero-Universitaria Città della Salute e della Scienza di Torino, Torino, Italy.",
    "Department of Oncology, Candiolo Cancer Institute FPO-IRCCS, Turin, Italy.",
    "Medical Oncology Unit 1, IRCCS Ospedale Policlinico San Martino, Genoa, Italy.",
    "Department of Health Sciences, Section of Biostatistics, University of Genova, Genoa, Italy.",
    "IRCCS Ospedale Policlinico San Martino, Genoa, Italy.",
    "Medical Oncology, Comprehensive Cancer Centre, AUSL-IRCCS di Reggio Emilia, Reggio Emilia, Italy.",
    "Università Cattolica del Sacro Cuore, Facoltà di Medicina e Chirurgia, Rome, Italy.",
    "Medical Oncology, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy.",
    "Department of Medicine (DAME), University of Udine, Udine, Italy.",
    "Unit of Medical Oncology, Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health, ASST Spedali Civili di Brescia, University of Brescia, Brescia, Italy.",
    "Department of Urology and Gynecology, Istituto Nazionale Tumori IRCCS Fondazione G. Pascale, Napoli, Italy.",
    "Department of Health Sciences, Section of Clinical Pharmacology and Oncology, University of Firenze, Florence, Italy.",
    "Medical Oncology Unit, Santa Maria Hospital, Terni, Italy.",
    "Department of Medical Oncology, IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) \"Dino Amadori\", Meldola, Italy.",
    "Oncology Unit, Santa Maria della Misericordia Hospital, Perugia, Italy.",
    "Department of Medical Oncology, Università Politecnica delle Marche, AOU delle Marche, Ancona, Italy.",
    "U.O. Oncologia, Ospedale di Camposampiero, Camposampiero, Italy.",
    "Oncology Unit, Department of Oncology and Hematology, Ramazzini Hospital, AUSL Modena, Carpi, Italy.",
    "Oncology 3 Unit, Istituto Oncologico Veneto - IOV IRCCS, Padova, Italy.",
    "Oncologia Medica Genitourinaria, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.",
    "Department of Medical Oncology, Azienda Ospedaliera Universitaria \"Maggiore Della Carità\", Novara, Italy.",
    "Department of Medical Oncology, AORN \"A. Cardarelli\", Napoli, Italy.",
    "Department of Medical Oncology, Cardinal Massaia Hospital, Asti, Italy.",
    "Medical Oncology Unit, Department of Oncology and Hematology, University Hospital of Modena, Modena, Italy.",
    "Clinical Oncology, Ospedale Arnas Civico, Palermo, Italy.",
    "Medical Oncology Unit, ASST Papa Giovanni XXIII, Bergamo, Italy.",
    "Department of Oncology, Bolzano Central Hospital, Bolzano, Italy.",
    "Medical Oncology Unit, AULSS 3 Serenissima, Mestre-Venice, Italy.",
    "Medical Oncology, ULSS 8 Berica, Vicenza, Italy.",
    "Department of Medical Oncology, Ospedale Michele e Pietro Ferrero, ASL CN2, Verduno, (CN), Italy.",
    "Department of Medical Oncology, IRCCS San Raffaele Hospital, Milan, Italy.",
    "Department of Medical Oncology, Centro di Riferimento Oncologico di Aviano CRO-IRCCS, Aviano, Italy.",
    "Medical Oncology Unit, Azienda Ospedaliera SS. Antonio e Biagio e Cesare Arrigo, Alessandria, Italy.",
    "Division of Medical Oncology, Humanitas Gavazzeni, Bergamo, Italy.",
    "Dipartimento di Tecnologie Innovative in Medicina & Odontoiatria, Università G. D'Annunzio, Chieti-Pescara, Chieti, Italy.",
    "Department of Oncology, Azienda Ospedaliera Universitaria Integrata di Verona, University of Verona, Verona, Italy.",
    "Unit of Medical Oncology and Biomolecular Therapy and Department of Medical and Surgical Sciences, CREATE Center for Research and Innovation in Medicine, University of Foggia, Policlinico Riuniti, Foggia, Italy."
  ],
  "article_type": "research article",
  "arxiv": null,
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      "name": "Marcello Tucci"
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      "name": "Maria Giuseppa Vitale"
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        27
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      "name": "Carlo Messina"
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    {
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      "name": "Lucia Bonomi"
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      "name": "Luca Tondulli"
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      "name": "Filippo Maria Deppieri"
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        31
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      "name": "Francesca La Russa"
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    {
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        1
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      "name": "Luigi Formisano"
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        32
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      "name": "Cinzia Ortega"
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      "name": "Brigida Anna Maiorano"
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      "name": "Arianna Dri"
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      "name": "Silvia Zai"
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      "name": "Emilia Cocorocchio"
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      "name": "Michele De Tursi"
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        38
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      "name": "Emanuela Fantinel"
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    {
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        39
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      "name": "Vincenza Conteduca"
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    {
      "name": "Cecilia Nasso"
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    {
      "name": "Camilla Sansi"
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    {
      "name": "Franco Nolè"
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    {
      "name": "Giulia Zago",
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    {
      "name": "Enrico Bronte"
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        7
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      "name": "Noemi Montobbio"
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  "bibtex": "https://research.draconitic.com/paper/2rwdm8jc0h8hv.bib",
  "cited_by": 0,
  "doi": "10.1080/2162402x.2026.2751848",
  "fulltext_url": "https://europepmc.org/articles/PMC13699842",
  "id": "2rwdm8jc0h8hv",
  "issns": [
    "2162-4011",
    "2162-402X"
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  "landing_url": "https://europepmc.org/article/MED/42912018",
  "language": "eng",
  "licence": "CC-BY-NC",
  "licence_label": "CC BY-NC",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc/4.0/",
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  "native_subjects": [
    [
      "heading",
      "Research Article"
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    [
      "openalex",
      "2740|Renal cell carcinoma treatment"
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  "openalex": "W7223253115",
  "pdf_url": "https://europepmc.org/articles/PMC13699842?pdf=render",
  "pmcid": "PMC13699842",
  "pmid": "42912018",
  "published": "2026-10-22",
  "publisher": "Taylor & Francis",
  "ris": "https://research.draconitic.com/paper/2rwdm8jc0h8hv.ris",
  "sources": [
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      "first_seen": "2026-10-30T12:20:10Z",
      "native_id": "MED:42912018",
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  "subjects": [
    {
      "field": "biology",
      "origin": "journal-openalex:2403|Immunotherapy and Immune Responses",
      "subfield": "immunology"
    },
    {
      "field": "medicine",
      "origin": "journal-openalex:2730|Cancer Immunotherapy and Biomarkers",
      "subfield": "oncology"
    }
  ],
  "title": "Real-world comparative outcomes of first-line immune combinations (ICI-ICI vs ICI-TKI) in metastatic renal cell carcinoma with sarcomatoid features.",
  "title_text": "Real-world comparative outcomes of first-line immune combinations (ICI-ICI vs ICI-TKI) in metastatic renal cell carcinoma with sarcomatoid features.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:36:21Z",
  "url": "https://research.draconitic.com/paper/2rwdm8jc0h8hv",
  "venue": "Oncoimmunology",
  "versions": []
}