{
  "abstract": "Objective: To evaluate whether preoperative serum total IgE, analyzed categorically and continuously, was associated with 6-month postoperative tympanometric status after type I tympanoplasty for chronic otitis media. Tympanic membrane closure and audiometric outcomes were also examined. Methods: This retrospective study included 171 operated ears from 171 unique patients with chronic otitis media who underwent type I tympanoplasty. The categorical analysis used the institutional assay upper reference limit of 60 IU/mL; a separate analysis treated IgE as a log2-transformed continuous variable. Tympanic membrane closure, tympanometry, and audiometry were assessed at 6 months. Abnormal tympanometric status was defined as a measurable peak pressure < -50 daPa or a type B tympanogram. Multivariable logistic regression evaluated factors associated with abnormal tympanometric status. Results: Of 171 patients, 101 had serum total IgE ≤ 60 IU/mL and 70 had IgE > 60 IU/mL. Abnormal 6-month tympanometric status occurred in 22/89 (24.7%) and 29/61 (47.5%) ears, respectively (p = 0.005). Tympanic membrane closure was 96/98 (98.0%) versus 61/68 (89.7%) (p = 0.033). A 6-month ABG ≤ 20 dB occurred in 87/94 (92.6%) versus 54/64 (84.4%) (p = 0.121). In complete-case multivariable analysis, IgE > 60 IU/mL (OR, 3.46; 95% CI, 1.56-7.70; p = 0.002) and poor mastoid pneumatization (OR, 4.68; 95% CI, 2.15-10.21; p < 0.001) were associated with abnormal tympanometric status. In the separate continuous analysis, each doubling of IgE was associated with higher adjusted odds of abnormal tympanometric status (OR, 1.25; 95% CI, 1.03-1.52; p = 0.023). Conclusions: Preoperative serum total IgE was associated with abnormal 6-month tympanometric status in both categorical and continuous analyses. The 60 IU/mL cutoff was an assay-specific reference limit rather than a validated postoperative risk threshold. The findings do not establish predictive or prognostic utility, clinically defined allergy, or an allergy-mediated causal mechanism.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Otolaryngology Head and Neck Surgery, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, China.",
    "Department of Otolaryngology Head and Neck Surgery, The Eighth Affiliated Hospital of Sun Yat-sen University, Shenzhen 518000, China."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 7,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Dan Chen"
    },
    {
      "affs": [
        1
      ],
      "name": "Yingying You"
    },
    {
      "affs": [
        0
      ],
      "name": "Luoying Yang"
    },
    {
      "affs": [
        0
      ],
      "name": "Jianyan Wang"
    },
    {
      "affs": [
        0
      ],
      "name": "Chengyu Ge"
    },
    {
      "affs": [
        0
      ],
      "name": "Peng Li"
    },
    {
      "affs": [
        0
      ],
      "name": "Yubin Chen"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/2rxgcdg1q981r.bib",
  "cited_by": 0,
  "doi": "10.3390/audiolres16050146",
  "fulltext_url": "https://europepmc.org/articles/PMC13701292",
  "id": "2rxgcdg1q981r",
  "issns": [
    "2039-4330",
    "2039-4349"
  ],
  "landing_url": "https://europepmc.org/article/MED/42930344",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2733|Ear Surgery and Otitis Media"
    ]
  ],
  "openalex": "W7214658469",
  "pdf_url": "https://europepmc.org/articles/PMC13701292?pdf=render",
  "pmcid": "PMC13701292",
  "pmid": "42930344",
  "published": "2026-09-28",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/2rxgcdg1q981r.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:22:01Z",
      "native_id": "MED:42930344",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42930344"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "journal-openalex:F28",
      "subfield": "neuroscience"
    }
  ],
  "title": "Preoperative Serum Total IgE Category and 6-Month Tympanometric Status After Type I Tympanoplasty for Chronic Otitis Media.",
  "title_text": "Preoperative Serum Total IgE Category and 6-Month Tympanometric Status After Type I Tympanoplasty for Chronic Otitis Media.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:22:01Z",
  "url": "https://research.draconitic.com/paper/2rxgcdg1q981r",
  "venue": "Audiology research",
  "versions": []
}