{
  "abstract": "Background: Poly‐L‐lactic acid (PLLA) is a biostimulator used for nasolabial fold (NLF) correction. This study evaluated product handling, tolerability, and aesthetic outcomes.\n\nObjectives: To assess handling and applicability of a PLLA formulation, tolerability, and pre‐specified effectiveness end points for NLF correction.\n\nMethods: This prospective, open‐label, uncontrolled, single‐center observational study included adults with moderate‐to‐very severe NLFs receiving up to three treatment sessions, with follow‐up at 4, 12, and 26 weeks after the last injection. Handling was assessed using a 12‐item questionnaire. Effectiveness was assessed using MAS‐NLF, IGAIS, and SGAIS.\n\nResults: Of 35 screened individuals, 33 were treated and 21 (63.6%) were assessed at Week 26. Handling was rated favorably. Four participants (12.1%) experienced adverse events, including treatment‐related slight bilateral swelling in two (6.1%). No serious adverse events, device deficiencies, papules, nodules or granulomas were documented through Week 26. At Week 26, improvement of at least one MAS‐NLF grade was recorded in 4/21 participants (19.0%), IGAIS of at least “improved” in 14/21 (66.7%) and SGAIS in 11/21 (52.4%).\n\nConclusions: Handling was rated favorably under the conditions studied, and descriptive improvements in NLF severity and global aesthetic ratings were observed. The uncontrolled design, sample size, and follow‐up limit conclusions regarding treatment‐specific effectiveness and uncommon or delayed adverse events.\n\nTrial Registration: German Clinical Trials Register (DRKS00032634; registered 6 September 2023)",
  "abstract_shown": true,
  "affiliations": [
    "CentroDerm Clinic Wuppertal Germany",
    "Faculty of Health University of Witten‐Herdecke Witten Germany",
    "Department of Dermatology, Venereology and Allergology Ruhr‐University Bochum Germany"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 3,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Thomas Dirschka",
      "orcid": "0000-0001-7804-5311"
    },
    {
      "affs": [
        0
      ],
      "name": "Marcus Kuchner",
      "orcid": "0000-0002-9710-3641"
    },
    {
      "affs": [
        0,
        2
      ],
      "name": "Lutz Schmitz",
      "orcid": "0000-0002-9627-2179"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/2s9x7k8nbdw6q.bib",
  "cited_by": 0,
  "doi": "10.1111/jocd.71251",
  "fulltext_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13724798/?tool=EBI",
  "id": "2s9x7k8nbdw6q",
  "issns": [
    "1473-2130",
    "1473-2165"
  ],
  "landing_url": "https://europepmc.org/article/PMC/PMC13724798",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Original Article"
    ],
    [
      "openalex",
      "2708|Facial Rejuvenation and Surgery Techniques"
    ]
  ],
  "openalex": "W7225103294",
  "pdf_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13724798/pdf/?tool=EBI",
  "pmcid": "PMC13724798",
  "pmid": null,
  "published": "2026-11-01",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/2s9x7k8nbdw6q.ris",
  "sources": [
    {
      "first_seen": "2026-11-03T15:20:51Z",
      "native_id": "PMC:PMC13724798",
      "source": "europepmc",
      "url": "https://europepmc.org/article/PMC/PMC13724798"
    },
    {
      "first_seen": "2026-11-04T12:23:18Z",
      "native_id": "PMC13724798",
      "source": "pmc",
      "url": "https://doi.org/10.1111/jocd.71251"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2708|Facial Rejuvenation and Surgery Techniques",
      "subfield": "general"
    }
  ],
  "title": "A Poly‐L‐Lactic Acid Formulation for Nasolabial Fold Correction: Handling, Tolerability and Effectiveness in a Prospective Observational Study",
  "title_text": "A Poly‐L‐Lactic Acid Formulation for Nasolabial Fold Correction: Handling, Tolerability and Effectiveness in a Prospective Observational Study",
  "type": "peer-reviewed",
  "updated_at": "2026-11-06T12:21:11Z",
  "url": "https://research.draconitic.com/paper/2s9x7k8nbdw6q",
  "venue": "Journal of cosmetic dermatology",
  "versions": []
}