{
  "abstract": "Background: Patients with advanced malignant adrenal tumors face poor prognoses with limited treatment options. Emerging data suggest that these rare tumors exhibit immunogenicity, potentially benefiting from intensified immunotherapy.\n\nMethods: The SPENCER trial (NCT04187404) evaluates EO2401, an off-the-shelf in vivo peptide immunotherapy containing three synthetic HLA-A*02 restricted-peptides called OncoMimic and derived from human gut commensals that exhibit molecular mimicry to tumor-associated antigens (BIRC5, FOXM1, IL13RA2) combined with nivolumab in patients with locally advanced or metastatic adrenocortical carcinoma (ACC) or malignant pheochromocytoma/ paraganglioma (PPGL). We performed T cell receptor (TCR) repertoire sequencing to profile the TCR architecture in ACC and characterize vaccination imprints.\n\nResults: Here we show that ACC patients are characterized by a restricted peripheral T cell richness. EO2401 does not expand highly shared TCR clones across patients but diversifies pre-existing T cell clusters. These clusters are not converging on known neoantigen-specific TCRs but exhibit generation probabilities characteristic of public clones some of which being shared across patients.\n\nConclusions: These findings suggest that EO2401-based peptide immunotherapy combined with checkpoint inhibition can broaden and activate public, pre-existing T cell clusters, potentially enhancing tumor-specific immune responses.",
  "abstract_shown": true,
  "affiliations": [
    "Division of Medical Oncology, University Hospital Basel, Basel, Switzerland",
    "Laboratory of Translational Immuno-Oncology, Department of Biomedicine, University and University Hospital Basel, Basel, Switzerland",
    "Department of Internal Medicine IV, Oncology/Hematology, Martin-Luther-University Halle-Wittenberg, Halle (Saale), Germany",
    "Enterome SA, Paris, France",
    "Laboratory of Cancer Immunology, Department of Biomedicine, University Hospital and University of Basel, Basel, Switzerland",
    "Università degli Studi di Brescia, Azienda Ospedaliera Spedali Civili, Brescia, Italy",
    "Department of Medical Oncology, Amsterdam UMC, Cancer Centre Amsterdam, Amsterdam, The Netherlands",
    "Endocrine Oncology, Gustave Roussy, Villejuif, France",
    "Internal Medicine, University Hospital Würzburg, Würzburg, Germany",
    "Vall d’Hebron University Hospital and Vall d’Hebron Institute of Oncology (VHIO), Barcelona, Spain",
    "Stanford Cancer Institute, Stanford University School of Medicine, Stanford, CA USA",
    "Department of Molecular Medicine and Surgery, Karolinska Institute, Stockholm, Karolinska University Hospital Solna, Stockholm, Sweden",
    "Medical Oncology, Rigshospitalet/University Hospital, Copenhagen, Denmark",
    "Medicine IV Endocrine Oncology, Ludwig Maximilians University of Munich, München, Germany",
    "Medical Oncology, Centre Léon Bérard, Lyon, France",
    "University Hospital Lille - Hôpital Claude Huriez, Lille, France",
    "Hospital Nord, Marseille, France",
    "Collaborative Research Institute Intelligent Oncology (CRIION), Freiburg, Germany"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 24,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Christoph Schultheiß",
      "orcid": "0000-0001-9789-5776"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Brenda Besemer"
    },
    {
      "affs": [
        2
      ],
      "name": "Edith Willscher"
    },
    {
      "affs": [
        2
      ],
      "name": "Lisa Paschold"
    },
    {
      "affs": [
        3
      ],
      "name": "Tifanny Mersceman"
    },
    {
      "affs": [
        3
      ],
      "name": "Alice Talpin"
    },
    {
      "affs": [
        0,
        4
      ],
      "name": "Clara Serger"
    },
    {
      "affs": [
        0,
        4
      ],
      "name": "Alfred Zippelius"
    },
    {
      "affs": [
        5
      ],
      "name": "Alfredo Berruti"
    },
    {
      "affs": [
        5
      ],
      "name": "Salvatore Grisanti"
    },
    {
      "affs": [
        6
      ],
      "name": "Catharina Willemien Menke-van der Houven van Oordt",
      "orcid": "0000-0002-5404-5883"
    },
    {
      "affs": [
        7
      ],
      "name": "Eric Baudin"
    },
    {
      "affs": [
        8
      ],
      "name": "Laura-Sophie Landwehr"
    },
    {
      "affs": [
        9
      ],
      "name": "Jaume Capdevila"
    },
    {
      "affs": [
        10
      ],
      "name": "Vivek Subbiah"
    },
    {
      "affs": [
        11
      ],
      "name": "Dan Granberg",
      "orcid": "0000-0002-4854-6075"
    },
    {
      "affs": [
        12
      ],
      "name": "Kirsten Gedske Daugaard"
    },
    {
      "affs": [
        13
      ],
      "name": "Alexandra Triebig",
      "orcid": "0009-0002-4728-0014"
    },
    {
      "affs": [
        14
      ],
      "name": "Thibault Gauduchon"
    },
    {
      "affs": [
        15
      ],
      "name": "Christine Do Cao"
    },
    {
      "affs": [
        16
      ],
      "name": "Marie-Eve Garcia"
    },
    {
      "affs": [
        3
      ],
      "name": "Joao Magalhaes"
    },
    {
      "affs": [
        3
      ],
      "name": "Laurent Chêne"
    },
    {
      "affs": [
        0,
        1,
        17
      ],
      "name": "Mascha Binder"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/2sd50e4bfkhy7.bib",
  "cited_by": 0,
  "doi": "10.1038/s43856-026-01755-8",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13720076/",
  "id": "2sd50e4bfkhy7",
  "issns": [
    "2730-664X"
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  "landing_url": "https://doi.org/10.1038/s43856-026-01755-8",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Article"
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      "2730|Cancer Immunotherapy and Biomarkers"
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  "pdf_url": "https://www.nature.com/articles/s43856-026-01755-8_reference.pdf",
  "pmcid": "PMC13720076",
  "pmid": "42410253",
  "published": "2026-07-06",
  "publisher": "Nature Publishing Group",
  "ris": "https://research.draconitic.com/paper/2sd50e4bfkhy7.ris",
  "sources": [
    {
      "first_seen": "2026-11-02T12:23:55Z",
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    {
      "field": "medicine",
      "origin": "openalex:2730|Cancer Immunotherapy and Biomarkers",
      "subfield": "oncology"
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  ],
  "title": "OncoMimic peptide-based immunotherapy EO2401 induces shared T cell clusters in patients with adrenal cancer",
  "title_text": "OncoMimic peptide-based immunotherapy EO2401 induces shared T cell clusters in patients with adrenal cancer",
  "type": "peer-reviewed",
  "updated_at": "2026-11-03T12:21:01Z",
  "url": "https://research.draconitic.com/paper/2sd50e4bfkhy7",
  "venue": "Communications Medicine",
  "versions": []
}