{
  "abstract": "BACKGROUND: (HL) is a multiparametric remote monitoring system designed to detect early signs of HF decompensation. Using a multicenter database, this real-world study evaluated whether responses to HL alerts could reduce HF-related hospitalization. METHODS AND RESULTS: We retrospectively analyzed 246 patients implanted with an HL-enabled implantable cardioverter-defibrillator or cardiac resynchronization therapy defibrillator across 8 Japanese centers. Patients were categorized as alert-responsive (AR; n=167) or non-responsive (NR; n=79). Alert responses included multidisciplinary review and telephone triage to determine the need for clinical visits. HF hospitalization rates during the alert-off (before activation) and the alert-on (after alert activation) periods were compared. During the alert-off period, 50 hospitalizations occurred over 648 person-years (77.1 per 1,000 person-years); during the alert-on, 91 hospitalizations occurred over 498 person-years (182.6 per 1,000 person-years). From the alert-off to the alert-on period, HF hospitalization increased 3.24-fold (95% confidence interval [CI] 1.63-6.41) in the NR group, but only 1.28-fold (95% CI 0.81-2.03) in the AR group. The relative increase in HF hospitalization was significantly attenuated in the AR group (adjusted relative ratio 0.40; 95% CI 0.18-0.89; P=0.025). CONCLUSIONS: Although HF-related hospitalizations progressively increase as the disease advances, real-world alert responses may reduce hospitalizations and healthcare costs in clinical practice.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 17,
  "authors": [
    {
      "name": "Takafumi Oka"
    },
    {
      "name": "Mitsuyoshi Takahara"
    },
    {
      "name": "Shohei Kataoka"
    },
    {
      "name": "Michio Nagashima"
    },
    {
      "name": "Koumei Onuki"
    },
    {
      "name": "Daigo Yagishita"
    },
    {
      "name": "Yoshifumi Ikeda"
    },
    {
      "name": "Risa Kanai"
    },
    {
      "name": "Yoshitaka Terazaki"
    },
    {
      "name": "Yasuhiro Yoshiga"
    },
    {
      "name": "Masakazu Fukuda"
    },
    {
      "name": "Takuo Tsurugi"
    },
    {
      "name": "Katsuhito Fujiu"
    },
    {
      "name": "Eriko Hasumi"
    },
    {
      "name": "Nobuhiro Nishii"
    },
    {
      "name": "Hiroki Iguchi"
    },
    {
      "name": "Yasushi Sakata"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/2sdvwtwx4me2e.bib",
  "cited_by": 0,
  "doi": "10.1253/circj.cj-26-0182",
  "fulltext_url": "https://www.jstage.jst.go.jp/article/circj/90/11/90_CJ-26-0182/_article",
  "id": "2sdvwtwx4me2e",
  "issns": [
    "1347-4820",
    "1346-9843"
  ],
  "landing_url": "https://www.jstage.jst.go.jp/article/circj/90/11/90_CJ-26-0182/_article",
  "language": null,
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "jstage-journal",
      "medicine/cardiovascular"
    ],
    [
      "openalex",
      "2705|Cardiac pacing and defibrillation studies"
    ]
  ],
  "openalex": "W7166728984",
  "pdf_url": "https://www.jstage.jst.go.jp/article/circj/advpub/0/advpub_CJ-26-0182/_pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-23",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/2sdvwtwx4me2e.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:24Z",
      "native_id": "10.1253/circj.cj-26-0182",
      "source": "jstage",
      "url": "https://www.jstage.jst.go.jp/article/circj/90/11/90_CJ-26-0182/_article"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2705|Cardiac pacing and defibrillation studies",
      "subfield": "cardiovascular"
    }
  ],
  "title": "Reduction in Heart Failure Hospitalizations Through Real-World HeartLogicTM Alert Response ― A Multicenter Study in Japan ―",
  "title_text": "Reduction in Heart Failure Hospitalizations Through Real-World HeartLogicTM Alert Response ― A Multicenter Study in Japan ―",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:17:24Z",
  "url": "https://research.draconitic.com/paper/2sdvwtwx4me2e",
  "venue": "Circulation Journal",
  "versions": []
}