{
  "abstract": "Lipid peroxidation, the radical-chain oxidation of membrane lipids, terminates in part through spin-selective encounters between lipid-peroxyl radicals. We ask how far a shaped magnetic field can steer this branch under spin relaxation and how that change propagates to the oxidation flux. Gradient-projection and bang–bang Pontryagin controls were evaluated with a stochastic-Schrödinger treatment of dipolar fluctuations and an independent Brownian-dynamics model. A best-found dipolar-scale field raises the triplet-initialised singlet termination yield from ΦS|T = 0.220 at 50 µT to 0.562 (+155%), with the bang–bang solution corroborating at 0.522; a bandwidth-filtered proxy retains 0.270. Under Brownian dynamics the control advantage remains positive throughout the sampled rotational-correlation-time range, and one field transfers across eight microdomain-size–diffusion parameter sets. Closing the spin calculation to classical autoxidation kinetics gives Ceff = −f/(1+f), where f is the fraction of peroxyl loss proceeding through bimolecular termination. Two limiting descriptions of the productive encounter population bracket the predicted suppression of oxidation flux in antioxidant-free liposomes at approximately 21–37%, and at approximately 4–10% for the bandwidth-filtered field. α-Tocopherol attenuates the response as interception comes to dominate, providing an internal experimental control. These values describe an elementary encounter and a minimal kinetic model, not whole-cell lipid peroxidation.",
  "abstract_shown": true,
  "affiliations": [
    "Facultad de Ciencias Exactas y Naturales (FCEN",
    "Universidad de Belgrano",
    "CONICET",
    "Departamento de Física Médica",
    "Instituto Balseiro",
    "Living Systems Institute and Department of Physics and Astronomy",
    "University of Exeter",
    "Johns Hopkins University Applied Physics Laboratory"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 4,
  "authors": [
    {
      "affs": [
        0,
        1,
        2
      ],
      "name": "Pablo R. Castello",
      "orcid": "0000-0002-2983-9294"
    },
    {
      "affs": [
        3,
        4
      ],
      "name": "Pablo Jimenez"
    },
    {
      "affs": [
        5,
        6
      ],
      "name": "Daniel R. Kattnig"
    },
    {
      "affs": [
        7
      ],
      "name": "Carlos F. Martino"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/2segvr38vxj3m.bib",
  "cited_by": 0,
  "doi": "10.26434/chemrxiv.15007151/v2",
  "fulltext_url": null,
  "id": "2segvr38vxj3m",
  "issns": [],
  "landing_url": "https://chemrxiv.org/doi/full/10.26434/chemrxiv.15007151/v2",
  "language": null,
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "1304|Electron Spin Resonance Studies"
    ]
  ],
  "openalex": "W7220726042",
  "pdf_url": "https://chemrxiv.org/doi/pdf/10.26434/chemrxiv.15007151/v2",
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-06",
  "publisher": "American Chemical Society (ACS)",
  "ris": "https://research.draconitic.com/paper/2segvr38vxj3m.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:22Z",
      "native_id": "10.26434/chemrxiv.15007151",
      "source": "chemrxiv",
      "url": "https://chemrxiv.org/doi/full/10.26434/chemrxiv.15007151/v2"
    }
  ],
  "subjects": [
    {
      "field": "biochemistry",
      "origin": "openalex:1304|Electron Spin Resonance Studies",
      "subfield": "biophysics"
    }
  ],
  "title": "Magnetic control of lipid–peroxyl termination yield under spin relaxation: from an optimised dipolar-scale field to a falsifiable kinetic criterion",
  "title_text": "Magnetic control of lipid–peroxyl termination yield under spin relaxation: from an optimised dipolar-scale field to a falsifiable kinetic criterion",
  "type": "preprint",
  "updated_at": "2026-10-30T12:17:22Z",
  "url": "https://research.draconitic.com/paper/2segvr38vxj3m",
  "venue": "ChemRxiv",
  "versions": []
}